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Biomedical subjects

S B Warren

Publications and source records attributed to S B Warren.

6 recordsLinked to original sources
PubMed1992

Lower threshold for referral for psychiatric treatment for adopted adolescents.

Epidemiological data on a national sample of 3,698 adolescents, of whom 145 were adopted, indicate that adoption significantly increases the likelihood of referral for psychiatric treatment even after controlling for the fact that adoptees display more behavior problems and come from more educated families. This is accounted for by the fact that adoptees are significantly more likely to be referred when they display few problems. Thus, contrary to popular myth and clinical lore, the overrepresentation of young adoptees in clinical settings is not attributable solely to the fact that adoptees are more troubled. Rather, adoptees do display more problems but they are also referred more readily even after controlling for extent of problems.

Adaptation, Psychological↗
PubMed1992

Intramedullary nailing of tibial nonunions.

Fifteen tibial nonunions, ranging nine months to 19 years after original injury, were treated with the Brooker intramedullary nail (IMN). The average number of previous failed surgeries was two. The fracture location ranged from several centimeters below the tubercle to 3 cm above the plafond. Twelve of 15 had bone grafting, and all 15 had fibular osteotomy at the time of the IMN procedure. Thirteen of 15 were reamed, and 11 of 15 were nailed open. Patients required an average of five postoperative days in the hospital, and 14 of 15 tibial nonunions healed uneventfully at an average of eight months after the IMN procedure. Weight bearing in a removable patellar-tendon-bearing (PTB) brace was encouraged in most cases by two to four weeks postoperative. One nonunion patent, traumatically refractured after rod removal, was treated at another hospital with dynamic compression plating and iliac crest bone graft; the fracture healed three months later but was considered an IMN treatment failure. There were no other significant complications. The IMN procedure encourages early return to function and reliably promotes union in even the most challenging and complex of tibial healing problems.

Adult↗
PubMed1992

Excision of heterotopic bone followed by irradiation after total hip arthroplasty.

Twelve patients who had had a total hip arthroplasty had extensive excision of heterotopic bone, followed by prompt, low-dose irradiation, between 1983 and 1990. Volumes of as much as 900 milliliters of heterotopic bone tissue were resected. Of these patients, eleven had excellent relief of pain, and all twelve gained an average of 45 degrees of flexion and 25 degrees of abduction. Two patients had a recurrence of heterotopic bone (Brooker et al. class II); however, only one of these patients was symptomatic and had a result that was considered a failure.

Combined Modality Therapy↗
PubMed1990

Heterotopic ossification after total hip replacement.

Heterotopic bone formation occurs in up to 70% of patients who have undergone a total hip arthroplasty. Although histologically similar to mature skeletal bone, the ectopic tissue limits postoperative motion and causes pain in 2% to 4% of patients. The ossification is classified and graded according to radiographic appearance. Males with bilateral hypertrophic osteoarthritis who have had prior hip surgery are at high risk. Prophylaxis with Indocin or low-dose irradiation treatment is effective. Excision and irradiation therapy can treat established bony bridges.

Ankylosis↗
PubMed1985

Effects of short-term cyclosporin-A on biomechanical properties of intact and fractured bone in the rat.

Cyclosporin-A is a new immunosuppressant drug being used widely for solid organ transplantation. The systemic effects of Cyclosporin-A on the skeletal system have not previously been defined. This study examined the effects of Cyclosporin-A on biomechanical properties of intact bone and fracture repair in a rat model. Closed midshaft femoral fractures were produced over a preplaced intramedullary pin. Cyclosporin-A, dissolved in olive oil and administered by gavage, was begun the day following surgery and continued for 14 consecutive days at a dose known to prolong solid organ allograft survival in rats (7 mg/kg/day), and a second group of control animals received comparable volumes of plain olive oil under identical circumstances. Groups of both experimental and control animals were killed at 4, 8, 12, or 16 weeks following fracture, after which both intact and fractured femurs were tested to failure in torsion. As judged by torque, angular deformation, stiffness, and energy absorption, Cyclosporin-A did not significantly alter the biomechanical properties of fracture repair or intact bone turnover. Based on current biomechanical data, we can find no reason to discourage the short-term clinical use of Cyclosporin-A in patients with or without fractures. Histomorphometric studies are required to accurately assess the biologic effects of this drug on bone biology and to complete the analysis of skeletal toxicity.

Animals↗