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Biomedical subjects

S Bülow

Publications and source records attributed to S Bülow.

At least 127 records · Page 7Linked to original sources
PubMed1984

The risk of developing rectal cancer after colectomy and ileorectal anastomosis in Danish patients with polyposis coli.

Fifty-eight Danish polyposis patients had been treated with colectomy and ileorectal anastomosis by the end of 1982. Three of these patients developed rectal cancer despite regular proctoscopic control, but one was probably an overlooked synchronous cancer. The cumulative risk at five and ten years after operation (actuarial method) was 3.5 and 13.3 per cent (95 per cent confidence limits 0-10.3 and 0-70.3 per cent, respectively), which seem to be acceptably low figures. This study supports the assumption that colectomy and ileorectal anastomosis is still the operation of choice in polyposis patients without rectal cancer.

Adenocarcinoma↗
PubMed1981

Whole gut irrigation with saline, tinidazole and colistin before colorectal operations.

To date, 27 patients scheduled for colorectal operations have had their bowels prepared the day before operation by whole gut irrigation with up to 151 of an electrolyte solution (14 patients), while the other 13 patients had infused in addition 0.51 of a solution containing 500 mg tinidazole and 1 MIU colistin. During the operation, samples were taken from the abdominal and perineal operation wounds and the colorectal mucosa by a velvet pad rinse technique, which involved transportation in a CO2-atmosphere and cultivation in an anaerobic cabinet. The number of anaerobic bacteria present in the colon was significantly lower after the use of antimicrobials, while there was no such difference with regard to aerobic bacteria. There were no differences between the two groups in preclosure bacterial densities of abdominal and perineal wounds. The total number of bacteria inoculated, the wound inoculum, was considerably lower after antimicrobial administration. There were no infections in the 13 patients treated with these antimicrobials, while 4 out of the 14 patients in the control group developed infections.

Adult↗
PubMed1980

Hereditary colon cancer syndromes: an in vitro study.

Assays of in vitro biological properties associated with cellular transformation revealed differences in cultured skin cells within the heritable colon cancer syndromes with and without polyposis coli. Such evidence suggested that an in vitro panel of biological assays could be used to recognize genotypes which increase the risk of colon cancer prior to clinical expression and supported the concept, long assumed on clinical differences, of genetic heterogeneity within the heritable colon cancer syndromes.

Adolescent↗
PubMed1980

Cimetidine for severe gastroduodenal haemorrhage: a randomized controlled trial.

During a period of 12 months, 88 patients with severe haemorrhage from gastric or duodenal ulcers or from erosive gastritis completed a double-blind trial of either cimetidine or placebo. Only patients needing immediate blood transfusion were admitted to the trial. It was found that in patients with severe bleeding from gastric or duodenal ulcers neither the severity of bleeding nor the incidence of emergency surgery was reduced by cimetidine. Furthermore, the treatment did not improve the mortality rate. It is concluded that patients with severe bleeding from gastric or duodenal ulcers will not benefit from immediate treatment with intravenous cimetidine.

Adult↗
PubMed1980

A randomized double-blind trial of glucagon in treatment of first attack of severe acute pancreatitis without associated biliary disease.

The effects of glucagon versus placebo were evaluated in a double-blind trial including only patients with a first attack of severe acute pancreatitis not associated with biliary disease. All 22 patients had deterioriation of their clinical condition, elevated serum amylase and pulse rate above 100/min. or shock. An initial dose of 1 mg. glucagon was given as a bolus injection followed by infusion of 6 mg. in 1,500 ml. saline/24 hr. for three days. All were treated with nasogastric decompression, fluids, calcium and antibiotics. Severe complications developed in five of the 10 patients receiving glucagon and in eight of the 12 given a placebo. Three of the 10 (glucagon) and five of the 12 (placebo) died from these complications. Hemorrhagic pancreatitis was found in 11 patients at laparotomy or autopsy. Three of the five with hemorrhagic pancreatitis in the glucagon group and four of the six in the placebo group died. Pooling the data of the present and two other studies makes it probable that glucagon has no effect on mortality from acute severe pancreatitis.

Acute Disease↗
PubMed1980

Carcinoid tumours of the appendix in young patients.

64 patients under forty years of age with appendical carcinoid tumor in Denmark 1943-67 have been followed 10-33 years after the operation. Recurrence is found in one patient with a tumor larger than 2 cm and local metastases. Appendectomy alone is generally a sufficient treatment. Right hemicolectomy is indicated in tumors larger than 2 cm, in cases with local metastases or if the resected appendix-base is not free of tumor in cases with tumor localized near the base. Invasion in the mesoappendix does not increase the frequency of recurrence.

Adolescent↗
PubMed1977

Reappraisal of surgery for suppurative cholecystitis.

Ninety-two patients with suppurative cholecystitis operated on as emergency cases were studied in retrospection. Obstructive cholangitis was seen in two, who eventually died. The mortality after cholecystectomy alone was related to the presence of stones in the common bile duct. The mortality after cholecystostomy alone was related to shock and septicemia, but not to the presence of common bile duct stones or obstructive cholangitis. It was concluded that suppurative cholecystitis with accompanying common bile duct stones should be treated with cholecystectomy and choledocholithotomy, because of the lower rate of reoperations and possibly lower mortality than after cholecystectomy alone; an exception should be made in patients with deterioration in clinical condition or patients in whom technical difficulties develop during the operation. These patients should be subjected to a cholecystostomy as the only emergency procedure.

Adolescent↗
PubMed1976

The incidence of male hermaphroditism in girls with inguinal hernia.

The incidence of male hermaphroditism in girls with inguinal hernias is estimated to be 1.4 per cent. From 1961 to 1972, 340 girls were admitted to the Department of Surgery at St. Josephs Hospital for hernial repair. One hundred and two patients had menstruated prior to the follow-up study. Buccal smears from the remaining patients were examined for Y chromatin-positive cells. We observed a zero per cent rate of male hermaphroditism, which is not significantly different from the aforementioned frequency, p greater than 0.05. Large scale prospective studies must be available before any conclusion can be drawn as to whether or not determination of the genetic gender prior to hernial repair in girls should be conducted as a routine procedure.

Adolescent↗
PubMed1975

Venous gangrene.

Venous gangrene is not a common disease. It develops as the extreme, irreversible phase of total thrombosis of the veins of an extremity. The literature is reviewed and 7 new cases are reported. Symptomatology, aetiology, pathogenesis and treatment are discussed. It is concluded that there is a significant causative relationship between malignant disease and venous gangrene.

Aged↗