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Biomedical subjects

S Bacsa

Publications and source records attributed to S Bacsa.

At least 19 recordsLinked to original sources

Complications after large vein catheterization.

Serious complications of the introduction of pacemaker electrodes and of the catheterization of large veins performed in the course of 6 years are discussed. The majority of the 24 observed complications occurred on the left side. In the case of constant suction and thoracic haemorrhage, surgical exposure is unavoidable. In five cases the complications were due to temporary pacemaker electrodes. Four of the patients died of organ damage. Three typical case records are presented.

Adult

Therapeutic results and complications of thoracic operations. Part I.

The therapeutic results and complications of 557 thoracic operations are evaluated. 94.4% of the patients recovered, 2.7% improved and 2.9% died. There appears to be a significant correlation between the therapeutic results, the diagnosis and the type of operation. The 7.0% wound infections were closely related to the age of the patient. The postoperative respiratory complications observed in 11.5% of the cases were in close relation to the diagnosis. The causes leading to respiratory complications and the length of the febrile period are discussed in detail, and the results are assessed in the light of data in the literature.

Adolescent

Investigation on the serum and lung tissue level of rifampicin in man.

After the oral administration of 600 mg rifampicin, we determined the rifampicin level of the lung tissue of 18 operated patients, as well as the rifampicin level of the pleural callus of one patient, that of the pericardial cyst of another, and the serum level of all the 20 patients. The serum level amounted to an average of 6.5 mcg/ml between 2 and 6hours after administration, and to 3.3 mcg/ml between 8 and 9 hours. The lung tissue level amounted to an average of 2.3 mcg/g. The lung rifampicin level reached 32-44-62 per cent of the serum level 2 to 9 hours after its administration. This concentration was found to meet treatment requirements of Mycobacterium tuberculosis, Gram-positive cocci, and certain Gram-negative bacteria-induced airway infections.

Administration, Oral

[Methicillin levels in the human serum, pericardial effusion and myocardium].

The antibiotic level in the serum, pericardial fluid and myocardium of 11 patients prepared for heart surgery was tested by means of the agar-diffusion method after the intramuscular administration of 1 g of methicillin. The mean level after 1 to 3 hours was 14.7 mcg/ml in serum, 1.7 mcg/ml in the pericardial fluid and 8.2 mcg/g in the myocardium. In the case of drug sensitivity, the myocardial methicillin concentration is sufficient for the treatment of Gram-positive infections. If the infection is localized in the pericardium, higher doses, local applications, drug combination or complex therapy might be called for.

Adolescent