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Biomedical subjects

S Bakalczuk

Publications and source records attributed to S Bakalczuk.

16 recordsLinked to original sources
PubMed2001

[Biophysical characteristics of cervical mucus after stimulation of ovulation by clomiphene citrate and HMG].

OBJECTIVES: Characteristics of cervical mucus during monofollicular stimulation of ovulation by clomiphene citrate and by clomiphene citrate with HMG was evaluated. MATERIALS AND METHODS: 226 women of couples treated for male factor infertility or idiopathic infertility were studied. Favourable parameters of cervical mucus in women treated by clomiphene citrate with HMG were found although they were worse than observed in spontaneous ovulatory cycle. RESULTS AND CONCLUSIONS: The E2/follicle index was used for evaluating efficiency of stimulation. It was the highest during cycles were CC and HMG were used, although they did not reflect the risk of hyperstimulation. Authors discuss the importance of their findings in cases when techniques of ART can not be applied.

Adult↗
PubMed2001

[Changes in carbohydrate metabolism of PCOS patients in cycle stimulated by rFSH].

UNLABELLED: 24 patients with clomiphene citrate-resistant PCOS were enrolled in the study. We used low-dose step up protocol of recombinant FSH administration. Ovulation induction by rFSH injection was commenced on 3 day of cycle, at a dose of 50 IU for 7 days initially. The dose was continued at 50 IU, and ultrasonographic scans were performed daily until a dominant follicle had developed to a size of at least 18-20 mm, at which point 5,000 IU of hCG was administrated. If no response was noted after 7 days, the dose was increased by 50 IU for a further 7 days. Insulin and glucose serum levels were determined 7 times: in days 3, 5, 8 of a cycle and later when diameter of ovarian follicle was 10, 12, 16 mm and in the day of hCG injection. Estradiol serum level was determined in 8 day of cycle and when diameter of ovarian follicle was 10, 12, 16 mm and in the day of hCG injection. BMI and WHR was determined in the day of admission to hospital. RESULTS: The correlation between mean insulin level in the examined cycle and BMI and as well as the correlation between mean insulin level and WHR were determined. Mean level of serum glucose increased as the level of estradiol raised. No influence of growth level on insulin level was detected.

Adult↗
PubMed2001

[Hysteroscopic correction of uterine malformations by small diameter hysteroscope with flexible needle].

The series of 14 hysteroscopic surgery procedures in case of septum uteri were analyzed. All women enrolled into the study were infertile. The malformations were diagnosed by hysterosalpingography and intravaginal ultrasound. The laparoscopic examination of intrauterine serosal surface and operative hysteroscopy were performed in the same time. The 8 mm diameter hysteroscopy with flexible needle was used. The uterine cavity solution was distended by sorbitol and mannitol. The patients left the hospital on the second postoperative day. There was one complication in this study: intravasation of distended fluid. After one month from surgery the pelvis was controlled by HSG. In 12 cases the uterine cavity was restored to a normal shape, in 2 cases the residual uterine septum of less than one centimeter was determined. We concluded that correcting the septum uteri by the small diameter hysteroscope (8 mm) with flexible needle is an effective and safety method for the uterine septum treatment.

Adult↗
PubMed1998

[The effect of various methods of luteal phase supplementation on serum progesterone level].

OBJECTIVES: Examined was the effect of luteal phase supplementation on serum progesterone level with the use of two methods: oral administration of 10 mg dydrogesterone twice daily since the detection of corpus luteum till the menstruation and intramuscular HCG administration in the dose 1500 IU every 4 days and 10 mg dydrogesterone twice daily in the same period. DESIGN: A randomized study, controlled by placebo. PATIENTS AND METHODS: 56 infertile women, with luteal phase deficiency assessed on the basis of basal body temperature (decrease shortly after the peak the luteal phase shorter than 11 days) and ovulation determined sonographically. Progesterone was evaluated by an EIA method, on the 3rd, 7th and 11th day since the corpus luteum occurred. RESULTS: The peak of progesterone concentration was assessed in the midluteal phase (7th day) in both supplemented groups, significantly higher than in the placebo group, also in group with dydrogesterone and HCG it was higher than in group with dydrogesterone alone. Progesterone concentration decrease on the 11th day after the ovulation to the values comparable with the placebo group. CONCLUSION: It has been found that both methods increase serum progesterone level in the time of an assumed implantation but they do not affect the premenstrual period if conception is not achieved.

Adult↗
PubMed1998

[Correlation of pituitary hormones in serum of male patients with fertility problems].

UNLABELLED: FSH, LH and prolactin serum levels estimations are the part of the most diagnostic procedures in andrology but there is their prediction value under discussion all the time. AIM: To judge the sensitivity of pituitary hormones serum levels estimation as the diagnostic method in male subfertility and to investigate the correlation between FSH, LH and PRL depending on their physiological or pathological ranges. MATERIAL AND METHODS: FSH, LH and PRL serum levels were estimated in 36 males with azoospermia or severe oligozoospermia (density below 5 mln sperm per milliliter) by EIA. The percentage of pathologic values for every hormones was counted. The statistic analyzes (for p. < 0.05) of correlation factor between every couple of hormones were performed in full investigated group and in subgroups which were formed in following way: A-12 men with pathologic FSH serum levels, B-9 men with pathologic LH serum levels and C-24 men with both physiologic gonadotropins serum levels. RESULTS: The percentage of FSH, LH and PRL pathologic values was in all subfertile men: 33%, 25% and 19.4% respectively. The correlation factor for FSH and LH was high in whole group (0.9484), it was the highest in both groups with FSH and LH pathologic levels (almost 1.0). In the group with physiological FSH and LH serum levels this positive correlation was significantly weak but also present (0.4107). The prolactin is completely independent without the correlation with any gonadotropins in any groups. CONCLUSIONS: 1. The sensitivity of the investigations of pituitary hormones during the diagnostic procedures of male fertility disturbances is poor. 2. Gonadotropins and prolactin infertile male serum levels are completely independent. 3. Positive correlation between FSH and LH increases in the pathological range of their values.

Follicle Stimulating Hormone↗
PubMed1998

Zinc levels in seminal plasma and sperm density.

Zinc levels in seminal plasma were measured. The study was done on 122, random selected males from infertile couples. The atomic absorption spectrophotometer was used. Sperm density of ejaculate was also determined. These parameters were compared in subgroups: normospermic and oligospermic and in classes of variable oligospermic severity. Semen serum zinc levels in normospermic men was significantly increased as compared to oligospermic men. There were no significant differences in zinc levels between the different classes of oligospermia.

Adult↗
PubMed1998

Ectopic pregnancy diagnosis in very high risk patients.

The authors analyse the effectiveness of ectopic pregnancy diagnosis in women with clinical history and high psychological motivation for treatment. The effectiveness of the diagnostic algorithm was studied in 21 women with previous history of infertility treatment (including 15 who had undergone tube surgery). The diagnostic process was begun between 20th and 25th days after the suspected conception. The only clinical symptom that the patients complained of was spotting (7 cases). The algorithm used serum HCG determination (EIA); in cases of HCG ranging between 2 mIU/ml and 1500 mIU/ml (or clinical uncertainty)-transvaginal sonography (with colour Doppler) was used. If ectopic pregnancy was suspected, laparoscopy was done. It was found that in 15 cases laparoscopic images agreed with diagnostic results; in 5 cases, the image obtained was false negative; in 1 case it was false positive. The diagnostic efficiency of sonography alone was higher than if it was correlated with HCG, but it, too, did not secure against false positive and false negative results. The conclusion was drawn that despite very high sensitivity (70%) and specificity (93%) of the diagnostic procedures used, in high-risk patients the diagnosis should be verified by laparoscopy.

Adult↗
PubMed1997

[Endometrial changes in the ovaries during full-term pregnancy: a case report].

The authors described case of 27 years old female patient treated due to infertility of unknown etiology. The female was pregnant after series of intrauterine insemination. During caesarean section due to pelvic longitudinal lie the chocolate cyst and endometriosis of the ovary were found. The authors did not find any information in the literature about coincidence of endometriosis of female reproductive organs and full-term pregnancy.

Adult↗
PubMed1994

[Seasonal changes in results of semen analysis from male members of an infertile married couple].

Analysis of 200 semen samples of men from childless couples was performed in order to evaluate the sperm characteristics during the year. Estimated were following features: semen volume, sperm density, motility and percentage of pathological forms. The sperm estimation data obtained from 4 seasons of the year was statistically evaluated. Statistically significant changes were found only in the percentage of pathological sperm forms. During the spring period the observed values were significantly higher than during summer and winter. From the correlation tables it appears that together with the increase of sperm density the percentage of pathological forms decreases. Whereas increase in density is correlated with the increase of sperm motility. It was also revealed that together with the increase of the percentage of pathological forms the motility decreases. Analogical results were obtained in all seasons of the year which indicates that there is a clear regularity existing. The least apparent dependencies were found in winter period.

Adult↗
PubMed1994

[Observation of some semen parameters in men with varicocele].

Among 172 examined male patients varicoceles have been found in 57.6% patients. The frequency of varicocele appearance increased according to the fall of sperm concentration. Simple relations between sperm motility and varicocele have not been observed. Larger per cent of pathological sperm forms in patients with varicoceles has been shown. In patients with varicoceles three times as frequent appearance of richer periprostatic and periseminnal blood vessels have been observed in comparison with patients without varicocele.

Adult↗
PubMed1994

[Level of zinc and magnesium in semen taken from male partners of married infertile couples].

There was a preliminary study performed on the differences of zinc and magnesium levels in semen serum from 46 males from the infertile couples. Zinc and magnesium concentration was measured by the use of atomic absorption spectrophotometer. There was no statistically significant differences noticed between the mean concentration of zinc and magnesium in normal and pathological semen serum. Zinc and magnesium levels did not show correlation with the volume of the sperm and with the percentage of pathological forms. Whereas in the cases with the pathological spermiograms there was positive correlation revealed between the concentration of zinc and magnesium and the quantity of spermatozoa in 1 ml along with the negative correlation with the percentage of motile spermatozoa.

Adult↗
PubMed1993

[Varices of the spermatic cord and endo-sonographic changes of urogenital organs in men with decreased values of certain sperm parameters].

A comparative analysis was carried out of sperm cell density, proportion of mobility and viability, and the proportion of morphologically abnormal sperm cells in 80 (74.6%) men with varices of the spermatic cord and 88 (52.4%) men without the varices. A significant shortening was observed of the viability time od the sperm cells, measured by the ability to maintain motion, in 57.5% of sperm samples from men with varices of the spermatic cord and in 39.8% of sperm samples from men without the varices. The shorter viability time was correlated with lower sperm cell density (20 million/ml) in the sperm samples. In endosonographic examinations performed at the same time, a coexistence was observed of varices and endosonographic changes in the prostate, seminal vesicles, and in a small proportion in the testicles. The coexistence of endosonographic changes and the varices was more frequently associated with decreased sperm cell density. The usefulness was demonstrated of sonographic examinations in the diagnosis and treatment of impaired fertility in men.

Adult↗
PubMed1993

[Some routine test parameters of semen taken from the male partner of infertile couples and the state of the urogenital tract (prostate, seminal vesicles, testicles, epididymis) examined by ultrasound].

The authors investigated 214 men with endorectal and percutaneous scrotal sonography. These men were treated for the reason of sperm defects. The age range was 22 to 52 years. They were married for 2-10 years and infertile. The sperm was defected in respect of low percentage of motility (< or = 50%) and vitality and increased percentage of morphological abnormalities. The paper is an attempt to find the correlation between the sperm vitality and the frequency of prostate, seminal vesicles, testes and ejaculatory ducts defects. These correlations were particularly evident in sperm samples with decreased sperm concentration (1-20 mln/ml). The authors suggested the usefulness of the finding in treating the male infertility.

Adult↗