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Biomedical subjects

S Banim

Publications and source records attributed to S Banim.

12 recordsLinked to original sources
PubMed1987

Effects of nisoldipine on left ventricular function during exercise or cold pressor stress.

The effects of a single oral dose of nisoldipine, 10 mg, were investigated in two groups of patients. Firstly, the effects of nisoldipine on exercise left ventricular function were assessed in 20 patients with chronic stable angina and coronary disease. Secondly, the effects of nisoldipine on the left ventricular response to cold pressor stimulation were examined in 12 patients with normal coronary arteries, who presented with typical ischaemic chest pain and abnormal exercise tests. All studies were performed using first pass radionuclide angiography and the new short half-life radiopharmaceutical, gold-195m. In patients with coronary disease, mean exercise time improved after nisoldipine (P less than 0.01). Both at the identical workload to that before treatment, and at a new peak workload, mean exercise left ventricular ejection fraction (LVEF) improved significantly after nisoldipine (P less than 0.01 and P less than 0.05 vs pretreatment levels, respectively). At the identical workload to that before treatment, 10 of 16 patients, who had initially developed angina, did not develop angina after nisoldipine, and 23 of 46 exercise-induced regional left ventricular abnormalities had normalized. In the patients with normal coronary arteries undergoing cold pressor stimulation, imaging was carried out at rest, and after 1 and 2.5 minutes of cold stimulation, before and one hour after oral nisoldipine. LVEF fell significantly during cold stimulation before nisoldipine administration, with 10 of the 12 patients showing an abnormal response. Nisoldipine did not lead to any attenuation of the heart rate and blood pressure response to cold, but mean LVEF did not fall at any cold pressor stage and only three patients showed an abnormal response.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Temporal evolution of changes in left ventricular function induced by cold pressor stimulation. An assessment with radionuclide angiography and gold 195m.

The evolutionary changes in left ventricular function induced by cold pressor stimulation were investigated at 90 second intervals by rapid sequential first pass radionuclide angiography using the short half life tracer gold 195m. The results in 12 subjects with normal coronary arteries were compared with those in 12 patients with coronary artery disease. Left ventricular ejection fraction fell significantly from resting values in both groups after 1 minute of cold pressor, but only in patients with coronary disease was the significant fall maintained at 2.5 and 4 minutes. In both groups, the maximum decrease in ejection fraction occurred after 1 minute, whereas the maximum rise in systolic blood pressure occurred after 2.5 minutes. New abnormalities of regional ventricular function developed in 10 normal subjects after 1 minute of cold, with a total of 12 new abnormal segments. Only two such segments were seen at the later stages of imaging. Twenty one new segments developed after 1 minute in the coronary disease group, and 13 segments remained abnormal after 4 minutes. Three patients, two of whom had left main stem stenoses, showed persistent abnormalities of ventricular function after 2 minutes of recovery from cold stimulation. Thus left ventricular function changes rapidly during a period of cold stimulation in both those without and those with coronary disease. When the cold pressor test is used with multiple gated equilibrium imaging, the timing of imaging may be crucial to the results and interpretation of the test. The discordance between functional changes and rise in blood pressure is further evidence that alterations in afterload are not solely responsible for cold induced abnormalities.

Adult↗
PubMed1979

Detection of a false left ventricular aneurysm by first-pass radionuclide ventriculography.

A false left ventricular aneurysm complicating an inferior myocardial infarction was successfully identified by computerized first-pass radionuclide ventriculography using a multicrystal gamma camera. The aneurysmal chamber exhibited paradoxical systolic expansion, a pattern of contraction confirmed by contrast cineangiography. Because of the propensity of false aneurysms to rupture, early noninvasive firm diagnosis is desirable and may be accomplished by first-pass radionuclide angiography.

Cineangiography↗