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S Bartsch

Publications and source records attributed to S Bartsch.

23 records · Page 2Linked to original sources
PubMed1993

[Intra-individual reproducibility of tilt table studies in diagnosis of vasovagal syncope].

Neurally-induced syncope appears to be the underlying pathophysiologic mechanism in many patients with unexplained syncope. Diagnosis of vasovagal syncope, however, remains difficult and constitutes in many cases an exclusion diagnosis. The present study thus aimed to determine the yield of tilt-table testing in the work-up of patients with unexplained syncope and most importantly to examine the reproducibility of the results of this method. Twenty-four patients with a history of syncope and 11 healthy volunteers were examined on 2 days. In 10 patients, symptoms could be provoked during tilting, in 8 during both tests, in 2 only on one occasion. Only 1 of 11 volunteers developed presyncope during tilting which was not reproducible during the second test. These findings resulted in a sensitivity of 42% and a specificity of 91% for the protocol employed in this study. Overall reproducibility was 91% which suggests that this tilt-table protocol is suitable for evaluation of therapeutic interventions in patients with neurally-mediated syncope.

Adult↗
PubMed1992

Expression of tenascin in the developing and adult cerebellar cortex.

Since tenascin may influence neuronal cell development, we studied its expression pattern using immunocytochemistry, in situ hybridization, Northern blot analysis, and immunochemistry in the developing and adult mouse cerebellar cortex. Tenascin immunoreactivity was detectable in all layers of the developing cerebellar cortex. In the external granular layer, only the radially oriented processes of Golgi epithelial cells were immunoreactive, whereas the densely packed cell bodies were immunonegative. Tenascin was hardly detectable at contact sites between migrating granule cells and processes of Golgi epithelial cells. Axons of granule cells in the molecular layer were immunoreactive, whereas their cell bodies in the internal granular layer lacked detectable levels of tenascin. By in situ hybridization, only Golgi epithelial cells and astrocytes of the internal granular layer and prospective white matter, but not nerve cells, could be shown to synthesize detectable levels of tenascin mRNA in the developing mouse cerebellar cortex. Thus, tenascin in the cerebellar cortex seems to be a glia-derived molecule that becomes adsorbed to neuronal surfaces in a topographically restricted pattern in situ. Levels of tenascin protein and mRNA decreased significantly with increasing age. In the adult, tenascin immunoreactivity was weak and mainly restricted to the molecular layer and tenascin mRNA was confined to Golgi epithelial cells, indicative for a functional heterogeneity in differentiated cerebellar astrocytes. Quantitative immunoblot analysis revealed that the 225 and 240 kDa components of tenascin were developmentally downregulated at a faster rate than the 190 and 200 kDa components, corresponding to the faster downregulation of the 8 kilobase (kb) mRNA species compared to the 6 kb mRNA species as revealed by Northern blot analysis. These observations indicate a differentially regulated expression of the tenascin components. We hypothesize that glia-derived tenascin modifies the functional properties of nerve cell surfaces and that tenascin is involved in such different morphogenetic events as neurite growth and oligodendrocyte distribution.

Animals↗
PubMed1988

[The Aubaniac subclavian catheter in surgical intensive care].

The subclavian catheter according to Aubaniac has worked extremely well in surgical intensive therapy through a four-year period of prospective studies. The complication rate was as 13.2 per cent, which was found to be acceptable, provided stringent observance of indications.

Adolescent↗