Biomedical subjects

S Beatović

Publications and source records attributed to S Beatović.

3 recordsLinked to original sources

PubMed1999

99Tcm-p-aminohippuric acid as a new renal agent.

99Tcm-p-aminohippuric acid (99Tcm-PAH) is a new renal radiopharmaceutical prepared from a lyophilized kit by the addition of sodium pertechnetate (Na99TcmO4). Each vial contains PAH, the calcium trisodium salt of diethylenetriamine pentaacetic acid (CaNa3DTPA) and stannous chloride (SnCl2.2H2O) in an inert atmosphere. It is a stable radiopharmaceutical with high radiochemical purity (> 95%). Its protein binding is very similar to that of 131I-OIH, but it is hydrophilic in character. Animal studies using 99Tcm-PAH have indicated that it provides renal images of satisfactory quality with no external background. Despite its almost identical radiochemical purity and HPLC analysis results to 99Tcm-DTPA, 99Tcm-PAH is rapidly secreted by the kidneys in a manner consistent with tubular secretion, as confirmed by rat probenecid studies, whereas 99Tcm-DTPA is excreted by glomerular filtration. The pharmacokinetic parameters of 99Tcm-PAH (t1/2(alpha)) = 2.5 min, t1/2(beta) = 41.7 min, Cl = 5.22 ml.min-1, Kel = 5.1 x 10(-4) min-1) differ from those of 99Tcm-DTPA. Evaluation of 99Tcm-PAH in two human volunteers confirmed its good renal characteristics: rapid disappearance from the vascular system, high uptake in kidneys followed by its very fast elimination, and low residual activity 20 min after its intravenous administration.

Animals↗

PubMed1999

Interobserver variability in 99mTc-DMSA renal scintigraphy reports: multicentric study.

BACKGROUND: The aim of the study was to evaluate the interobserver variability and reproducibility of the renal scintigraphy reports. METHODS: The study was prospective performed in 60 99mTc DMSA scintigraphies (116 kidneys), done in one centre, displayed on X ray films as analogue 300 kcounts images in 4 standard projections. Six observers from 4 different centres (group A), including three observers from one institution (group B), were asked to interpret original scans. Seven parameters of scintigraphy protocol were analysed with at least two responses: kidney size (1), uptake (2), outlines (3), scars (4), SOL (5), differential function (6) and conclusion (7). RESULTS: Among 116 kidneys, concordant results in interpretation of seven points of report from 1 to 7, in the group A were found in 62%, 42.5%, 45%, 9%, 47%, 52% and 34%, and In the group B in 72%, 55%, 59%, 22%, 62%, 60% and 41% respectively. Some improvement in concordant reporting was noted in the group of 3 observers, in comparison of group of all, statistically significant in category of scar reports (p < 0.01). CONCLUSIONS: Results suggest to use of standardised criteria and terminology in interpretations, to improve low interobserver reproducibility and objectivity of renal scintigraphy reports, particularly in evaluation of renal scars.

Journal Article↗

PubMed1996

[Quantitative indicators of renal function in scintigraphy with mercaptoacetyl-triglycine in patients with transplanted kidneys (99m TC MAG3 in the quantitative evaluation of the transplanted kidney)].

99mTc MAG3 is the radiopharmaceutical agent that provides simultaneous investigation of renal perfusion, functional parenchyma and collecting system. Clearance of MAG3 which is equal to its tubular extraction rate (TER) and other quantitative parameters of renal function can be determined at the same time. The aim of the study was to analyze importance of TER, clearance index (CI) and renal accumulation rate (RA) of MAG3 in the assessment of the functional status of renal transplants. 31 kidney transplant recipients and 14 healthy donors were investigated. Dynamic renal scintigraphy was carried out 20 min. after i.v. injection of 150-220 MBq MAG3. Clearance was determined by single sample volume distribution method. For the calculation of CI and RA counts from transplant region acquired during the second minute of study were used. Results of TER, CI and RA were correlated with blood urea (Pu), serum creatinine (Pcr) and creatinine clearance (Ccr). The sensitivity of TER, CI and RA in well functioning kidney graft as well as in chronic rejection were analyzed. We concluded that: TER, CI and RA are more sensitive in comparison with Pu, Pcr and Ccr in quantitative assessment of renal transplant function; sensitivity of TER is greater than the sensitivity of CI and RA.

Humans↗