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Biomedical subjects

S Belli

Publications and source records attributed to S Belli.

68 records · Page 4Linked to original sources
PubMedDate not supplied

[High risk of pleural mesothelioma among the state railroad carriage repair workers].

Exposure to asbestos in a facility for the repair of railroad carriages in Bologna was initially studied in 1980, when the Local Health Unit started a program of primary prevention on request of the Unions. At that time workers employed in jobs with high exposure to asbestos were identified. The mortality experience of these 173 subjects was investigated from 01.01.1979 through 31.12.1997, and compared to that of the population of Emilia Romagna. SMR for all causes was 69, with upper limit of the confidence interval lower than 100; this was largely due to a significant decrease of cardiovascular mortality. Among neoplasms, there was a significant excess of pleural mesothelioma (6 observed, 0.09 expected); one more subject died for peritoneal mesothelioma and one for malignant mesothelioma of unspecified site. About half of the subjects deceased for neoplastic disease (8/17) were affected by mesothelioma.

Humans↗
PubMedDate not supplied

The effect of additional enamel etching and a flowable composite to the interfacial integrity of Class II adhesive composite restorations.

This in vitro study evaluated the interfacial integrity of Class II resin composite restorations. The influence of a flowable composite and additional enamel etching was also evaluated. Deep, saucer-shaped Class II cavities were prepared in the mesial and distal proximal surfaces of 25 extracted human molars and assigned to five treatment groups. The gingival margins were extended to approximately 1 mm above the CEJ in 40 cavities and below the CEJ in 10 cavities. The prepared cavities were then restored with a self-etching primer system (Clearfil Liner Bond II) and a hybrid resin composite (Clearfil AP-X), with and without a flowable composite (Protect Liner F) and additional enamel etching with 37% phosphoric acid gel (K-etchant). After finishing, polishing and thermocycling (4 and 60 degrees C, x300), the samples were longitudinally sectioned through the restorations and resin-tooth interfaces were observed directly under a laser scanning microscope. Statistical analysis indicated that the use of a flowable composite produced significantly more (p = 0.04) gap-free resin-dentin interfaces than teeth restored without the flowable composite. However, both flowable composite and enamel etching could not prevent gap formation at enamel-resin interfaces and crack formation on enamel walls.

Acid Etching, Dental↗
PubMedDate not supplied

[The mortality among the makers of vinyl chloride in Italy].

A mortality study was performed on 5,946 vinyl chloride (VC)-polyvinyl chloride (PVC) workers of the nine Italian plants. The aims of the study were to investigate the cause-specific mortality of workers exposed to VC in production and polymerization stages and to ascertain whether exposure is associated with a higher risk of cancers other than liver angiosarcoma. An incident cohort was enumerated in five plants, a mixed cohort in two and a cross sectional one in the remaining two facilities. Cause-specific Standardized Mortality Ratios (SMR) were calculated for the six incidence cohorts with a sufficiently long follow-up period. Both Italian and regional rates were used for the comparison. A pooled analysis of six cohorts was performed. For deceased persons, information from death certificates was used in the mortality analysis. Additional clinical and pathological data were sought for all decreased individuals (Best Evidence = BE). The results of the study confirm the carcinogenic action of vinyl chloride on the liver but not on the other suggested target organs (i.e., lung, lymphopoietic tissues, brain). A deficit for all causes of death and cardiovascular disease was evident in most cohorts and in the pooled cohort. Analysis of BE data showed a broad spectrum of carcinogenic action of VCM on the liver as demonstrated by the occurrence of both angiosarcomas and other histotypes of tumours.

Cause of Death↗
PubMedDate not supplied

[Mortality among lead-zinc miners in Val Seriana].

The mortality experience of 1392 lead-zinc-silver miners (Gorno, Northern Italy) employed in the period 1/1/1950-31/12/1980 and followed-up to 31/12/1986 was examined. Two separate estimates of the radon exposure level are available: 0.60 and 0.36 working levels respectively. The silica exposure level was not assessed. Vital status was ascertained for 95.6% of the cohort members and their mortality was compared with expected deaths based on national rates. Significant excess mortality from esophageal cancer, stomach cancer, lung cancer, respiratory tuberculosis, respiratory diseases and deaths from external causes was found among underground miners. Surface workers show significantly increased mortality from liver and bile ducts cancer, hepatic cirrhosis, respiratory tuberculosis and respiratory diseases. Based on the 16.4 excess lung cancer cases among underground miners and their cumulative radon exposure, an attributable risk estimate ranging from 9.78 and 16.31 cases per million person-years and WLM (Working Level Month) was calculated.

Adolescent↗
PubMedDate not supplied

Respiratory disorders and lung function impairment in pyrite miners.

A research study was carried out at a pyrite mine in Niccioleta, southern Tuscany, during the period 1980-1983 to investigate the possible effects of gaseous and particulate pollutants on the respiratory function of mine workers. The study was undertaken to fill the gap in recent scientific information in this field and also collect data which could be used for future planning of epidemiological and environmental controls at the mine. For the most exposed underground workers a dust exposure of 1.04 mg/m3 of inhalable dust and 0.60 mg/m3 of respirable dust was found. The average quartz content was less than 1.5% in both types of dust. Median exposures of the most exposed risk group were 6.0 ppm for carbon monoxide (CO), 0.22 ppm for nitrogen dioxide (NO2), 0.09 ppm for sulfur dioxide (SO2). The health effects of gaseous and particulate pollutants were studied by comparing the respiratory symptoms and lung function data of the miners with those of a reference group. A significantly increased prevalence of simple chronic bronchitis was found among underground miners when compared to the reference group. This condition was not associated with functional impairment of obstructive nature. Chest x-rays revealed 14 cases of p type pneumoconiosis.

Adult↗
PubMedDate not supplied

[Mortality of workers employed at an asbestos cement manufacturing plant in Senigallia].

The mortality (1948-1990) was investigated in 561 workers employed in an asbestos cement plant in Senigallia (Central Italy). A significant increase in lung cancer was observed in male subjects (SMR: 276; 95% C.I.: 175.2-414.8, 23 observed). The excess mortality was a function of the induction-latency time. Five deaths were observed among women, one of which due to malignant pleural neoplasm.

Asbestos↗
PubMedDate not supplied

[Mortality due to causes correlatable to asbestos in a cohort of workers in railway car construction].

A study was made of the mortality experience of a cohort of railway carriage construction workers with the aim of detecting asbestos-induced disease. The cohort included 1534 men who were active as at 01.01.1970 and/or hired up to 30.06.89. Vital status was ascertained for 97.7% of the cohort. The mortality experience of the cohort was compared with that of the population of the Campania Region. Altogether, 194 deaths were observed (SMR: 0.88). Significant mortality deficits were associated with circulatory causes (SMR: 0.64, 58 observed), non-malignant respiratory causes (SMR: 0.59, 12 observed), and accidents (SMR: 0.39, 5 observed). A significant increase in mortality from all neoplasms was detected (SMR: 1.25, 69 observed), mainly due to an excess of lung cancer (SMR: 1.45, 28 observed), pleural cancer (SMR: 4.72, 3 observed), and peritoneal cancer (SMR: 7.47, 2 observed). The excess of mortality from respiratory neoplasms mainly affected subjects who had started employment more than 20 years previously.

Asbestos↗
PubMedDate not supplied

[A mortality study of recipients of compensation for asbestosis in Italy (1980-1990)].

The cause-specific mortality experience of a cohort inclusive of all subjects compensated for asbestosis in Italy (altogether 3417 persons--2776 men and 641 women), was studied from 31.12.1979 through 30.6.1990. Forty-eight subjects, corresponding to 1.4% of the cohort, were lost to follow-up, while it was not possible to ascertain the cause of death of 78 subjects, corresponding to 6.9% of the deceased. Observed mortality was compared with expected figures, derived from the Italian population mortality rates. The study showed significant increases in mortality from all causes (SMR 153, 1134 obs), respiratory disease (SMR 388, 218 obs), all neoplasms (SMR 192, 438 obs), namely lung (SMR 289, 190 obs), pleura (SMR 2745, 34 obs), peritoneum (SMR 1372, 14 obs), intestine and rectum (SMR 186, 36 obs) and ovary (SMR 545, 6 obs). A significantly decreased mortality was observed for cardiovascular disease (SMR 85, 266 obs), diabetes (SMR 37, 8 obs) and disease of the nervous system (SMR 29, 3 obs). The increase in neoplasms of lung, pleura and peritoneum was significant in both genders, while the increase in intestinal neoplasms was significant among women but not among men. Exposure in the manufacture of asbestos-cement products, the shipbuilding and textile industries accounted for most of the observed mortality excess.

Asbestosis↗
PubMedDate not supplied

[Cause-specific mortality of asbestos-cement workers compensated for asbestosis in the city of Bari].

The cause-specific mortality of 233 asbestos cement workers employed by the Fibronit company in Bari and compensated for asbestosis was investigated. Cohort members were enrolled on 31.12.1979 and followed through 30.4.1997; follow-up was completed for 98.3% of study subjects, and causes of death were ascertained for 96.6% of deceased subjects. Observed mortality was contrasted to that expected according to cause-sex-age- and calendar time-specific rates of the population resident in the Apulia Region. All causes observed mortality exceeded expected value (SMR: 117, 87 observed), due to a significant' increase in pneumoconiosis (SMR: 11238, 14 observed) and malignant neoplasms (SMR: 163, 38 observed)). A significant decrease of circulatory diseases was found (SMR: 64, 18 observed). Among cancer deaths, the following sites showed a significant excess: lung (SMR: 206, 17 observed), pleura (SMR: 2551, 4 observed), mediastinum (SMR: 2367, 2 observed) and peritoneum (SMR: 2877, 2 observed). The excess mortality due to asbestosis, respiratory cancer and peritoned neoplasms can be causally attributed to occupational asbestos exposure.

Asbestos↗