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Biomedical subjects

S Bender

Publications and source records attributed to S Bender.

At least 37 records · Page 2Linked to original sources

Young chronic patients and substance abuse.

The prevalence of substance abuse was investigated in 100 young chronic patients consecutively admitted to a long-term private psychiatric hospital. Data were obtained from diagnostic research interviews with each subject at admission. Half of the subjects had concurrent diagnoses of psychiatric disorder and substance abuse. One-third of the dual-diagnosis patients began using substances before the onset of a diagnosable psychiatric disorder, and they more often had a diagnosis of schizophrenia. Half of the dual-diagnosis patients abused three or more drugs. Implications of the findings for treatment and community management of dual-diagnosis patients are discussed.

Adolescent

Günther vena caval filter: results of long-term follow-up.

A Günther vena caval filter was implanted in the inferior vena cava in 59 patients to prevent pulmonary embolism. This newly available device, which can be inserted percutaneously via a 10-French introduction system, has three filtering planes. No complications occurred at the puncture site. Follow-up included clinical examinations (54 patients), plain radiographs (50 patients), and CT scans (41 patients); these examinations were performed up to 21 months after implantation. Caudal migration of the filter occurred in 35 (70%) of the 50 patients who had radiographs, but no cranial or oblique movement occurred. Occlusion of the filter was noted in three (7%) of 41 patients who had CT examinations. Thromboemboli were seen inside the filter in 16 (39%) of the 41 patients who had CT scans. Recurrent pulmonary embolism was not observed after filter implantation. The Günther vena caval filter seems to be a satisfactory device for preventing pulmonary embolism.

Adult

Peer review.

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Humans

Chorionic villus sampling: experience with an initial 940 cases.

Of over 1000 patients referred to the Genetics & IVF Institute for chorionic villus sampling, 10% had an abnormal gestational sac at the time of initial presentation. Villus sampling could not be performed in 0.6% of cases, usually because of fibroids. Chorioamnionitis, probably related to the procedure, occurred in two patients (0.2%). The total fetal loss was 2.4%, which is not significantly different from the background fetal loss rate reported in normal pregnancies after eight weeks of gestation. The procedure-related loss was estimated as approximately 0.6%. The cytogenetic analysis routinely used was "direct" trophoblast karyotyping. There were no false-negative diagnoses. Trophoblastic mosaicism was observed in 1.3% of samples. Amniocentesis was performed in 3.5% of cases because of chorionic villus sampling failure, chorionic mosaicism, or elevated maternal serum alpha-fetoprotein (MSAFP) concentrations. Chorionic villus sampling was not associated with falsely elevated MSAFP levels at 15-18 weeks' gestation. Chorionic villus sampling has proved a safe and accurate prenatal diagnostic method associated with relatively low risk when performed by an experienced team, although additional amniocentesis will be necessary in a small percentage of pregnancies.

Adult

Haemophilus influenzae type b opsonins of intravenous immunoglobulins.

Immunoglobulin G may be prepared by different methods for intravenous infusion and administered as replacement therapy for hypogammaglobulinemia. Intravenous immunoglobulins prepared by different methods were compared in vitro for their ability to opsonize Haemophilus influenzae type b in the absence of complement and subsequently induce neutrophil chemiluminescence. While the antibody contents, measured by an enzyme-linked immunosorbent assay and radioimmunoassay, were equivalent, the immunoglobulin prepared by a non-molecular modifying method (ion-exchange chromatography) had the greatest ability to induce bacterial-neutrophil interaction, measured by chemiluminescence, while a reduced and alkylated immunoglobulin had the least. Thus, preparative methods may have a profound effect upon the function of intravenous immunoglobulins. The biological function of immunoglobulins for clinical use can be compared easily by neutrophil chemiluminescence.

Haemophilus influenzae

Plasmacytoid myoepithelioma of a minor salivary gland.

Plasmacytoid myoepitheliomas are rare salivary gland neoplasms that probably represent a variant of the pleomorphic adenoma. They appear to occur more frequently in the minor salivary glands of the mouth. The mean average age at time of diagnosis of intraoral lesions is 18.8 years. Cytologic pleomorphism is a frequent histologic feature, which has led to a questionable diagnosis of malignancy in five out of ten cases. Caution is advocated in the evaluation of a salivary gland neoplasm with such features, and confusion with primary squamous cell or undifferentiated carcinoma of the salivary glands should be avoided. Patients who have cytologically pleomorphic lesions should be assessed for evidence of metastases. Rapid growth, neurologic evidence of sensory or motor dysfunction, and bone invasion should be regarded as ominous clinical parameters. Therapy should be directed toward complete surgical extirpation.

Adult

Hodgkin's disease of the jaws. Review of the literature and report of a case.

Hodgkin's disease of the jaws is extremely rare. A review of the literature has revealed only seven previously reported cases, five in the mandible and two in the maxilla. A new case of Hodgkin's disease of the mandible is reported. The patient had features of chronic osteomyelitis of the mandible. After resection, a Hodgkin's type of infiltrate was found in the mandibular condyle. The histologic subtype was lymphocyte-depleted, and the clinical staging was IV-B. The patient died 7 months after the mandibular lesion was discovered. From previous reported cases and this additional case, it appears that the prognosis for patients with Hodgkin's disease of the mandible is very poor.

Adult

Cystic fibrosis.

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Adolescent

Infertility.

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Female

Kinetics of bile acid metabolism in experimental blind loop syndrome.

In an experimental model of the contaminated small bowel syndrome, Eriksson's washout technique was used to study bile salt metabolism. Bile salt secretion rate was increased from 204-7 +/- SD 36-5 mumol/100 g body weight/24 h to 329-9 +/- 146-6, pool size from 33-4 +/- 5-4 mumol/100 g BW to 42-5 +/- 7-2, and biliary flow from 6-6 +/- 1-72 ml/100 g BW/24 h to 8-4 +/- 2.1. Detailed analysis of the washout curves gave indirect evidence of a short-circuit jejunohepatic shunt in the model contaminated small bowel syndrome. Parameters of this shunt were calculated with 9-1 mumol/100 g BW for 'short-circuit' pool size and 13-8 for its circulation frequency.

Animals