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Biomedical subjects

S Bergner-Rabinowitz

Publications and source records attributed to S Bergner-Rabinowitz.

At least 19 recordsLinked to original sources
PubMed1987

Food-borne outbreak of group G streptococcal sore throat in an Israeli military base.

A food-borne outbreak of sore throat caused by Lancefield group G beta-haemolytic streptococci and involving 50 persons occurred in May 1983 in an Israeli military camp. All of the patients available for clinical examination had sore throat and difficulty in swallowing. Exudative tonsillitis occurred in 46% of the patients and the body temperature was above 37.5 degrees C in 81%. The pattern of attack was uniform over the base and 37 became ill during the night and morning of the 5 May. Thirty-two (84%) of the throat cultures taken from 37 patients grew group G beta-haemolytic streptococci. Eight of 29 contacts were positive for group G beta-haemolytic streptococci and 6 of the 28 foodhandlers examined had positive cultures of the same group. The organism was also isolated from one food sample. The epidemiological and laboratory investigations indicated that a food handler, a convalescent carrier of group G streptococci, might have been the source of infection. Assumptions on the potential of non-group A streptococci to cause epidemics are discussed.

Acute Disease↗
PubMed1983

Serotype distribution of penicillin-resistant pneumococci and their susceptibilities to seven antimicrobial agents.

A total of 229 clinical isolates of Streptococcus pneumoniae recovered from 225 patients were serotyped and tested for susceptibility to penicillin G, ampicillin, mezlocillin, cefazolin, erythromycin, clindamycin, chloramphenicol, and sulfamethoxazole-trimethoprim. Of all the isolates, 48 (21.0%) showed intermediate resistance and 17 (7.4%) showed resistance to penicillin G. Penicillin-resistant strains had higher minimal inhibitory concentrations of ampicillin, mezlocillin, and cefazolin than did penicillin-susceptible strains. Resistance to erythromycin and clindamycin was rare (1.3 and 0.9%, respectively). Of the isolates, 8.7% were resistant to sulfamethoxazole-trimethoprim, and all were susceptible to chloramphenicol. Penicillin resistance was associated with 13 serotypes. Serotypes 14, 19F, 19A, and 23F were both highly prevalent and frequently penicillin resistant.

Anti-Bacterial Agents↗
PubMed1982

Effects of subminimal inhibitory concentrations of chloramphenicol, erythromycin and penicillin on group A streptococci.

Group A streptococci strains were grown in broth containing subminimal inhibitory concentrations of chloramphenicol, erythromycin and penicillin, and tested for possible changes in colonial morphology, activity and amount of cellular and extracellular components. The following components were tested: T protein, M protein, opacity factor, lipoteichoic acid, hyaluronic acid, streptolysin S, streptolysin O, DNase, hyaluronidase and NADase. Sub-MICs of these drugs produced variable changes in the bacteria. They increased the amount of hyaluronic acid and hyaluronidase, decreased the amount of M protein, and enhanced phagocytosis and the release of lipoteichoic acid. The results indicate that sub-MICs of chloramphenicol, erythromycin and penicillin may affect the pathogenicity and toxinogenicity of group A streptococci.

Chloramphenicol↗
PubMed1979

Effect of leukocyte hydrolases on bacteria. XV. Inhibition by antibiotics, metabolic inhibitors, and ultraviolet irradiation of the release by leukocyte extracts, trypsin, and lysozyme of lipopolysaccharide from gram-negative bacteria.

Leukocyte extracts, trypsin, and lysozyme are all capable of releasing the bulk of the LPS from S. typhi, S. typhimurium, and E. coli. Bacteria which have been killed by heat, ultraviolet irradiation, or by a variety of metabolic inhibitors and antibiotics which affect protein, DNA, RNA, and cell wall synthesis no longer yield soluble LPS following treatment with the releasing agents. On the other hand, bacteria which are resistant to certain of the antibiotics yield nearly the full amount of soluble LPS following treatment, suggesting that certain heatlabile endogenous metabolic pathways collaborate with the releasing agents in the release of LPS from the bacteria. It is suggested that some of the beneficial effects of antibiotics on infections with gram-negative bacteria may be the prevention of massive release of endotoxin by leukocyte enzymes in inflammatory sites.

Anti-Bacterial Agents↗
PubMed1979

Immune response to extracellular and somatic antigens in streptococcal infection and sequelae.

The aim of the present study is to define that temporal relationships of the IgM and IgG responses to streptococcal group A carbohydrate (CHO) in rabbits and in man. Rabbits were immunized with group A streptococci and the development of anti-group A carbohydrate (ACHO) was studied. ACHO which appeared one week after the beginning of immunization belonged to the 19S class of immunoglobulins (IgM). A two- to four-fold rise in ACHO titers and immunoglobulins of the 7S class (IgG) were observed after two weeks. Three weeks after the beginning of immunization, the ACHO titer was at a maximum. In the following months no further rises in titer were seen, and the antibodies belonged mostly to the IgG class. IgM and IgG responses to streptococcal CHO and to extracellular antigens in patients with pharyngitis, acute rheumatic fever (ARF), and acute glomerulonephritis (AGN) were studied. Higher values of IgM were found in pharyngitis and AGN sera than in ARF sera, probably reflecting the interval between streprococcal infection and time of bleeding. ACHO antibodies persisted in patients' sera for long periods and belonged to IgG and IgM. This suggests a continuous, rather than a persistent, production of ACHO.

Acute Disease↗
PubMed1978

Type distribution of beta-hemolytic streptococci in Israel: a 10-year study.

A survey was carried out over 10 years on the distribution of beta-hemolytic streptococci, their identification, and the clinical implications. Curtures were typed by the conventional agglutination and precipitation methods and by enzyme production. The present survey indicates the changes in streptococcal ecology of the various serotypes. Epidemics of acute pharyngitis with complete absence of rheumatic fever provided suggestive evidence that not all group A types are associated with rheumatic fever. The survey also emphasizes the occurence of non-group A streptococci in human infection.

Israel↗
PubMed1977

Antibody response to group A streptococci in an epidemic of streptococcal pharyngitis.

An epidemic of acute pharyngitis involving 280 cases occurred in a kibbutz in Israel during the fall and winter of 1972-1973. Group M and/or T type 12 streptococci was associated with the outbreak. No cases of rheumatic fever and no acute nephritis appeared in spite of the vigorous immune response to both cellular and extracellular antigens of group A streptococci documented in 50% to 80% of patients, suggesting that strain variation may be a feature of rheumatogenicity as well as nephritogenicity of group A streptococcal pharyngitis.

Adolescent↗
PubMed1977

Preparation of type-specific anti-M streptococcal sera by ummunization with acid-hydrolyzed cells.

The present study describes a method which simplifies the preparation of type-specific anti-M streptococcal sera. The procedure is based on vaccination with acid-hydrolyzed cells. The method makes possible the preparation of antisera from M strains which are problematic by conventional vaccination and is very useful for preparing all anti-M sera. The antisera obtained by the above method are devoid or almost devoid of cross-reactive antibodies.

Antibodies, Bacterial↗
PubMed1977

Six new Salmonella sub-genus III serotypes isolated from snakes in Israel.

Six new Salmonella sub-genus III serotypes (Arizona) were isolated from snakes in Israel. Their antigenic structure was established as follows: S. arizonae 16:Z52:Z35 (Ar.25:26-21); S. arizonae 18:1,v:e,n,x,z15 (Ar.7a,7b:23-28); S. arizonae 21:i:1,5(7) (Ar.22:33-30); S. arizonae 41:c:e,n,x,z15 (Ar.13:32-28); S. arizonae 51:k:z35 (Ar.1,2:29-21); and S. arizonae 53:1,v:z35 (Ar.1,4:23-21).

Animals↗
PubMed1976

Studies on opacity factor production by pharyngeal isolates of group A streptococci.

Production of opacity factor (OF) by 841 pharyngeal isolates of group A streptococci from schoolchildren in Casper, Wyoming was studied along with T- and M-typing of the streptococcal strains. The majority (89%) of M-typable strains were OF-negative in contrast to M-nontypable isolates, 45% of which were OF-positive. There was no apparent relation between the production of OF by the M-nontypable isolates and the type of infection (symptomatic vs. asymptomatic), degree of positivity of initial culture, antistreptolysin O response, and failure to eradicate the organisms by treatment with antibiotics. However, seasonal shifts in the prevalence of M-nontypable OF-positive strains provided evidence of change in streptococcal ecology, such a shift would not have been detected by T-typing alone. Thus, OF production is an additional epidemiologic marker that is helpful in differentiating M-nontypable group A strains that bear common T-antigens.

Child↗
PubMed1976

Salmonella and Arizona from snakes in the Judean desert (1974-1975).

Ninety-four (77.7%) of the 121 snakes captured during the years 1974-1975 in the Judean desert were found to carry Salmonella and/or Arizona organism. Sixty-six snakes (54.4%) harboured only one serotype. From 19 animals (15.7%) both Salmonella and Arizona organisms were isolated. From 9 snakes (7.5%) 2 or 3 serotypes of Arizona were isolated. Only 27 snakes (22,3%) harboured no detectable Salmonella nor Arizona in their intestinal contents.

Animals↗
PubMed1973

Evaluation of streptozyme and antistreptolysin O tests in streptococcal pyodermal nephritis.

The evaluation of the streptozyme test in sera from 34 patients with streptococcal pyodermal nephritis was studied. Ninety-seven percent of the patients developed high titers of antistreptozyme antibodies on the first bleeding after hospitalization, in contrast to only 40% of patients who developed elevated antistreptolysin O titers. The high antistreptozyme titers declined during convalescence and reached normal levels in the sixth month after onset of the disease. The most significant fall in titers occurred between 1 and 2 months from the onset of disease. The streptozyme test may be particularly helpful as a rapid screening test for antibodies in streptococcal pyodermal nephritis.

Adolescent↗