Biomedical subjects

S Berndt

Publications and source records attributed to S Berndt.

13 recordsLinked to original sources

PubMed1995

[Subacute bromide poisoning caused by a bromine-containing "nerve tonic"].

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Bromides↗

PubMed1982

[Lithium as a psychotropic drug. Experimental studies on its mechanism of action].

The effect of lithium on the cAMP metabolism was studied in rat brain. It was shown that: 1. Acute and subacute doses of lithium have no effect on the cAMP content of the forebrain of rats while chronic administrations significantly reduce the cAMP level in the brain by 30%; 2. the activities of the cerebral cAMP and cGMP phosphodiesterases are not affected by lithium in vitro; 3. the adenyl cyclase in rat brain homogenates stimulated by sodium fluoride and noradrenaline is inhibited dose-dependently in the mM range and 4. adenyl cyclase in isolated cells from the rat forebrain is very sensitive to inhibition by lithium in the therapeutically relevant microM range. With all due caution in transferring experimental results to the mechanisms of action of drugs in humans, it is obvious from these results in comparison with the effect of lithium on hormone-sensitive adenyl cyclases from extracerebral tissues that the effect of lithium salts in manic psychoses may be due to inhibition, and their prophylactic action probably to a "stabilizing" of cerebral adenyl cyclases.

Adenylyl Cyclases↗

PubMed1977

[Anthropometric studies in healthy children of a large town. I. Methods].

Based on the development of systematic investigations into child growth in the GDR, the importance of normal values of exact anthropometric parameters, which have to be checked every 10 years, is to be emphasized. For this reason, 1500 patients of the Pediatric Clinic of the Erfurt Medical School in the age between 1 and 3,5 years, were anthropometrically measured applying the slightly modified definitions by Martin-Saller 1959. Body length, trunk length, width of shoulders and pelvis as well as 10 limb measures and 7 skull measures were taken.

Anthropometry↗

PubMed1977

[Anthropometric studies in healthy children of a large town. 2. Results and normal values].

Mean values and standard deviations found in a population of 1500 children in the age between 1 and 3,5 years of 21 anthropometric parameters are given. They are statistically different and can be used as normal values. The growth of boys and girls is shown to be steady with age, in particular, as for as length and width measures are concerned. There are some significant sex differences. The practical use of the results is tested at present.

Anthropometry↗

PubMed1975