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Biomedical subjects

S Berrada

Publications and source records attributed to S Berrada.

At least 19 recordsLinked to original sources
PubMed2006

Mental health of Moroccan women, a sexual perspective.

Sexuality is a complex process coordinated with neurological, vascular, and endocrine systems. It incorporates family, societal, and religious beliefs and interpersonal relationships. Sexuality in the Muslim world is further complexed by tradition and discrimination of women. Studies conducted in Ibn Rushd University Psychiatric Center, Casablanca, Morocco, explored various aspects of sexuality in a traditional Muslim society: sexual behaviour (representative sample of Casablanca population n=728), sexual dysfunction (n=644), prevalence of abuse during childhood, effect of breast removal on sexuality (prospective study on 100 patients), effect of menopause on sexuality (comparative study between Moroccan and Tunisian samples, n=200), pregnancy and sexuality (follow up study in primary health care, n=100), and Ramadan and sexuality among healthy fasting people.

Adult↗
PubMed2006

Prevalence and psychosocial correlates of depressed mood during pregnancy and after childbirth in a Moroccan sample.

The objective of the current study was to determine the prevalence of depression among 100 women followed from the first trimester of pregnancy to 9 months after delivery. Mini International Neuropsychiatric Interview, Edinburgh Postnatal Depression Scale and Paykel Life Events Inventory were used. Seventeen per cent of the subjects experienced depression during postpartum, 19.2% started their episode during pregnancy. Psychosocial variables were positively correlated to depression during pregnancy.

Adult↗
PubMed2005

[Pseudocontinent perineal colostomy].

AIM: This prospective study was designed to evaluate functional results of a pseudocontinent perineal colostomy (PCPC) using Schmidt's technique. METHODS: Functional results in eight patients whose rectum were resected due to cancer or anal epidermoid carcinoma and reconstructed by PCPC between January 1995 and July 2002 in our institution were evaluated. Surgical technique and post-operative care were described. Morbidity, functional results and degree of patient satisfaction were reported. Median follow-up was 40 months (18-70 months) and was completed in 100% of patients. RESULTS: There were no operative deaths. Four patients had post-operative complications, whose two patients had partial disunion of sutures, and two patients had urinary infection that was treated by adequate antibiotherapy. No conversion to a definitive abdominal colostomy was performed. On a functional level, one patient has normal continence, six had gas incontinence, and one has occasional minimal soiling. Seventy-five percent of patients were either highly satisfied with their continence. DISCUSSION: PCPC is a reliable technique, which can be proposed as an alternative to a left iliac colostomy following amputation of the rectum due to cancer, provided that certain requirements are met: careful selection of patients, informed consent, flawless surgical technique and lifetime daily colic irrigation.

Carcinoma↗
PubMed2004

[Pathological fracture of the femur in a patient with a venous malformation].

We observed a pathological fracture of the femur in a 21-year-old woman with a venous malformation. Physical examination and plain x-rays disclosed a pathological bone. Biopsy revealed the venous malformation. The extent of the lesion that involved the entire quadriceps muscle was detailed with duplex-Doppler, computed tomography and arteriography. The patient was treated with an intramedullary nail. Intra-operative bleeding necessitated transfusion (packed cells and frozen plasma). Outcome was favorable. Bone healing was achieved at seven months.

Adult↗
PubMed2003

Prevalence of erectile dysfunction and its correlates: a population-based study in Morocco.

To obtain data on the prevalence of erectile dysfunction (ED) and its correlates, along with help-seeking behaviour, 655 randomly selected men at least 25 y old, residing in Casablanca, Morocco, were recruited. They responded to a questionnaire administered by five trained sociologist interviewers. Information on demographics, concomitant diseases, drugs, and sexual activity was collected. ED was prevalent in 54%, increased noticeably with age, and was highly prevalent between both the illiterate and those employed. Risk factors were diabetes, hypertension, heart disease, and smoking. Limited sexual satisfaction, low frequency of intercourse, and a disturbed psychological state with depressed mood had negative effects on erectile function. Given its prevalence in our country, ED should be considered an important medical problem with a multifactorial aetiology, making the cooperation of a multidisciplinary management team highly recommended.

Adult↗
PubMed1997

Presenting features at diagnosis and complications of hemophilia in Dakar: apropos of 25 cases.

In order to describe the presenting features at diagnosis and complications of hemophilia in Dakar, we conducted a study of hospital records between October 1991 and January 1993. Twenty-five cases of hemophilia were identified. We found that only 4% of our patients were diagnosed in the first 6 months of life whereas 64% of patients were diagnosed between 6 months and 5 years of age, 32% were detected between 5 years and 14 years of age. The presenting feature at diagnosis was external bleeding in 60% of cases and internal bleeding in 40%. 92% of cases were hemophilia type A and only 8% hemophilia type B. 56% of patients had mild hemophilia, 40% moderate and only 4% severe disease. Hemophiliac arthropathy was present on radiography in 76%. Complications were dominated by repeated joint bleeding, which was present in 92% of patients, and repeated hematomas (80% of patients). A functional handicap was present in 60% of cases. 12% of transfused hemophiliacs developed an inhibitor and 4% of patients were HIV positive. Greater awareness of hemophilia amongst the medical community as well as continued efforts to improve care for hemophiliacs in Senegal are necessary.

Adolescent↗
PubMed1997

Transposition-mediated transcriptional overexpression as a mechanism of insecticide resistance.

It has been proposed that amplification of genes for esterase that provide resistance to insecticides may originate from transposition events. To test this hypothesis, we have constructed a minigene coding for a soluble acetylcholinesterase under the control of a nontissue-specific promoter (hsp70). When introduced into Drosophila, the gene is expressed in all tissues and the extra acetylcholinesterase produced confers a low level of insecticide resistance (twofold). The minigene was mobilized by crossing the initial transformant with a strain providing a source of P-element transposase. After 34 generations of exposure to the organophosphate parathion, we obtained a strain with a higher resistance (fivefold). This strain had only one extra Ace gene, which overexpressed acetylcholinesterase. Thus, following transposition, resistance resulted from the overexpression of a single copy of the gene and not from gene amplification.

Acetylcholinesterase↗
PubMed1995

The effect of recombinant human basic fibroblast growth factor rhFGF-2 on human osteoblast in growth and phenotype expression.

This paper describes the studies of human recombinant basic fibroblast growth factor (rhFGF-2) for its effects on human osteoblast growth and phenotype expression. During a 24-h period of treatment, rhFGF-2 highly stimulated DNA synthesis in a dose-related fashion with a maximum stimulation of 150% for 1 ng/ml. On the other hand, rhFGF-2 decreases alkaline phosphatase activity, synthesis of type I collagen, and cumulative amount of osteocalcin. Moreover, rhFGF-2 provoked a threefold increase in the amount of intracellular cAMP. Scatchard plots show the presence of two classes of [125I] rhFGF-2 receptors. This data suggests that rhFGF-2 which stimulate cell replication may act indirectly as an anabolic agent and stimulate some of the phenotypic expression markers.

Adult↗
PubMed1994

Effect of a derivatized dextran on human osteoblast growth and phenotype expression.

Water soluble derivatized dextran named E9 with a molecular weight of 45,000 g l-1 containing 58% methyl carboxylic acid unit, 19% benzylamide unit, and 26% sulfonate with a specific anticoagulant activity of 0.29 IU mg-1 was studied for its effects on human osteoblast growth and phenotype expression for short-term treatment. At concentrations between 1 ng ml-1 and 1 microgram ml-1 E9 has no effect on DNA synthesis whereas at higher concentrations DNA synthesis is inhibited in a dose related fashion (87% for 400 micrograms ml-1). For concentrations which do not modify osteoblast growth, E9 promotes alkaline phosphatase activity, type I collagen and osteocalcin synthesis with a maximum effect for 0.1-1 microgram ml-1. It has a synergistic effect with hPTH increasing AMPc. Moreover, osteonectin synthesis was enhanced in a dose-dependent manner between 0.1 and 5 micrograms ml-1. These results seem to indicate that E9 is able to stimulate human osteoblast phenotype expression and could be useful in clinical applications.

Adult↗
PubMed1993

[Hydatid cyst of the liver. Treatment by resection of the cyst wall. Our experience apropos of a series of 495 cases].

From January 1976 to December 1990, 495 cases of hydatid cyst of the liver were treated by resection of the cyst wall. The mean age of the patients was 42 years with a female predominance (71% of cases). Confirmation of the diagnosis was essentially based on ultrasonography. At operation, the hydatid cysts were located in the right lobe of the liver in 83% of cases. The hepatic dome (segments VII + VIII) was involved in 52% of cases. After resection of the cyst wall, biliary tract lesions required common bile duct drainage with a Kehr drain in 50 cases, transcystic drainage in 22 cases and cysto-biliary disconnection in 22 cases. In every case, drainage of the residual cyst cavity was performed by a two-way catheter. Seven deaths were recorded in this series, including one from anaphylactic shock associated with intracystic injection of formalin, 3 from bronchopulmonary complications, 2 from subphrenic abscesses and 1 after surgical revision for evisceration on the 5th day. The postoperative morbidity and, consequently, the hospital stay depended on the condition of the pericystic tissues. The mean hospital stay was 12 days in the case of soft pericystic tissues and 32 days in the case of fibrotic and calcified pericystic tissues. Due to the benign nature of hydatid cysts of the liver, the authors emphasise the value of resection of the cyst wall which carries a lower operative risk and which can be performed by most surgeons.

Adolescent↗
PubMed1992

[Ophthalmologic manifestations in patients under chronic hemodialysis].

Ocular modifications were assessed in a prospective study carried out on 61 chronically hemodialyzed patients. Their mean age was 39.6 years (range: 7-73 yr) and the mean duration of dialysis was 30.5 months. The loss of visual acuity was especially associated with cataracts or refractive disorders. Corneal-conjunctival calcifications were found in 36% of the patients and were statistically significantly correlated with the duration of hemodialysis. Eyeground modifications were observed in 36% of the subjects; 21.3% of them were hypertensive retinopathies. Cataracts were less common (5%) than small calcifications in the lens (24.5%). Conjunctival biopsies taken from two patients confirmed the presence of calcium salt deposits under the conjunctival epithelium.

Adolescent↗
PubMed1992

[Heller's operation in the treatment of idiopathic megaesophagus. Apropos of 25 cases].

The authors report 25 cases of idiopathic mega-oesophagus treated by Heller's myotomy via an abdominal incision with prevention of gastro-oesophageal reflux by means of Toupet, Dor or Nissen procedures. The results, with a follow-up of 2 to 13 years, were considered to be good in 82% of cases with 2 moderate results (9%) and two failures (9%). The authors consider Heller's operation to be the operation of choice in preference to forced dilatations.

Adolescent↗
PubMed1991

[Hydatid cysts of the spleen: splenectomy or conservative surgery?].

Conservative surgery of the spleen has become very popular. The authors report 36 cases of splenic hydatid cysts. This third site of hydatid disease is frequently associated with few symptoms and clinical examination only reveals splenomegaly, which has typical features on ultrasonography. Twenty-four splenectomies were performed with a mortality of 8.3% and a morbidity of 37.5%, while 12 resections of the roof of the cyst were performed with no mortality and a morbidity of 16.6% after a follow-up of 2 to 13 years. The authors consider that resection of the roof of the cyst constitutes of operation of choice, as it is conservative and safe, regardless of the anatomical conditions.

Adolescent↗