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S Bhalla

Publications and source records attributed to S Bhalla.

At least 19 recordsLinked to original sources
PubMed2003

Sixth nerve schwannoma: a case report with literature review.

A 40-year-old woman presented with diplopia and left VI nerve palsy. After investigations, diagnosis of a meningioma in the parasellar-prepontine region was considered. Following angiography and embolization, near-total excision of the tumour attached to abducens nerve was performed. Histological examination was consistent with the diagnosis of schwannoma. This is the thirteenth case report of a schwannoma of cranial nerve VI and the first such case where embolization of feeding tumour vessels was performed.

Abducens Nerve Diseases↗
PubMed2001

Malignant peripheral nerve sheath tumor of the cauda equina.

Only one case of malignant peripheral nerve sheath tumor (MPNST) affecting the cauda equina region has been reported earlier. A 32-year-old male with congenital multiple subcutaneous swellings presented with low back pain, progressive paraparesis and bladder-bowel dysfunction. Magnetic resonance imaging (MRI) demonstrated a heterogeneously enhancing intradural lesion at L2-L4. At operation, on opening the dura, multiple nodular, firm matted masses attached to the lumbosacral nerve roots were encountered. Peripheral lesions were partially excised. Histopathological exam revealed varied cellularity with necrosis and pleomorphic nuclei suggestive of MPNST. MRI features, pathophysiological characteristics and the literature are reviewed.

Adult↗
PubMed2001

Post-lung transplantation bronchiolitis obliterans syndrome: usefulness of expiratory thin-section CT for diagnosis.

PURPOSE: To assess the usefulness of thin-section expiratory computed tomography (CT), as compared with that of thin-section inspiratory CT, in detecting airway obstruction and air trapping in pediatric lung transplant recipients with bronchiolitis obliterans syndrome (BOS). MATERIALS AND METHODS: Thin-section CT scans were obtained at full inspiration and end expiration in 21 pediatric lung transplant recipients with proved BOS and in 41 transplant recipients with normal airways. True diagnosis was based on pulmonary function test results. Inspiration CT scans were scored for extent of decreased attenuation of the lung parenchyma; expiration CT scans were scored for extent of air trapping. RESULTS: The sensitivity of inspiratory CT for enabling diagnosis of BOS was 71%; the specificity, 78%; the positive predictive value, 62%; and the negative predictive value, 84%. The sensitivity of expiratory CT for enabling diagnosis of BOS was 100%; the specificity, 71%; the positive predictive value, 64%; and the negative predictive value, 100%. Expiratory CT scores correlated more strongly (rho = 0.75, P <.01) with pulmonary function test-based scores than did inspiratory CT scores (rho = 0.48, P <.01). Nominal logistic regression analysis revealed that expiratory CT was a more powerful predictor of true diagnosis (P <.01) than was inspiratory CT (P =.10). CONCLUSION: Expiratory CT is sensitive for depicting BOS-related airway abnormalities and may be more useful than inspiratory CT for diagnosis of small airway obstruction.

Adolescent↗
PubMed2000

Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome.

We have previously shown that only a fraction of the newly synthesized human delta opioid receptors is able to leave the endoplasmic reticulum (ER) and reach the cell surface (Petäjä-Repo, U. E, Hogue, M., Laperrière, A., Walker, P., and Bouvier, M. (2000) J. Biol. Chem. 275, 13727-13736). In the present study, we investigated the fate of those receptors that are retained intracellularly. Pulse-chase experiments revealed that the disappearance of the receptor precursor form (M(r) 45,000) and of two smaller species (M(r) 42,000 and 39,000) is inhibited by the proteasome blocker, lactacystin. The treatment also promoted accumulation of the mature receptor form (M(r) 55,000), indicating that the ER quality control actively routes a significant proportion of rescuable receptors for proteasome degradation. In addition, degradation intermediates that included full-length deglycosylated (M(r) 39,000) and ubiquitinated forms of the receptor were found to accumulate in the cytosol upon inhibition of proteasome function. Finally, coimmunoprecipitation experiments with the beta-subunit of the Sec61 translocon complex revealed that the receptor precursor and its deglycosylated degradation intermediates interact with the translocon. Taken together, these results support a model in which misfolded or incompletely folded receptors are transported to the cytoplasmic side of the ER membrane via the Sec61 translocon, deglycosylated and conjugated with ubiquitin prior to degradation by the cytoplasmic 26 S proteasomes.

Cell Line↗
PubMed2000

Cure in a case of primary hepatic lymphoma.

Primary hepatic lymphoma is rare malignancy. Cures in this disease are uncommon. We report a young male who was diagnosed as a case of primary lymphoma of the liver in 1992. He was treated with chemotherapy only, which included CHOP (Cyclophosphamide, Adriamycin, Vincristine and Prednisolone) - six cycles; and IMVP-16 (Ifosfamide, Methotrexate and Etoposide) -four cycles. The patient is now disease free and alive for more than five years.

Adult↗
PubMed1999

Role of ketamine in convulsions.

It can be concluded from the present study that ketamine showed dose-dependent anticonvulsant effect on MES in mice. It is presumed that this anticonvulsant effect of ketamine could be due to blockade of excitatory amino acid NMDA receptors. It was potentiated by anticonvulsants like diazepam and DPH but was found to be insensitive to naloxone. These findings suggest the involvement of NMDA receptors and their antagonists in epilepsy. Ketamine thus can be given as add-on therapy in refractory cases, and may prove to be useful as an anticonvulsant in future.

Animals↗
PubMed1998

The linear intravertebral vacuum: a sign of benign vertebral collapse.

OBJECTIVE: We describe 11 patients with radiographically visible linear intravertebral vacuums to increase awareness of this benign finding that is diagnostic of ischemic necrosis of the vertebral body (Kümmell's disease). MATERIALS AND METHODS: We retrospectively reviewed the radiologic and clinical histories of 11 patients seen at our institution between 1991 and 1997 in whom the linear intravertebral vacuum phenomenon had been diagnosed. Imaging included plain radiographs in all patients, CT scans in three, bone scintigrams in three, and MR images in three. RESULTS: Twelve linear intravertebral vacuums associated with vertebral compression deformities were visible in 11 patients from T8 to L2, four at T12, and four at L1. Of the 12 linear intravertebral vacuums, seven (58%) were seen by the initial interpreting radiologist. The mean age of these patients was 76.6 years. The female:male ratio was 10:1. During the period of analysis, two patients were known to have malignancy, one with metastasis to the spine but not to the affected vertebral body. One patient, who underwent equivocal MR imaging for malignancy, later underwent bone biopsy, which showed no neoplasm within the collapsed vertebra. Of the remaining nine patients, one was undergoing chronic corticosteroid therapy and another had a history of radiation therapy to the spine. Seven of the 11 patients had histories of falling, prompting radiographs of the spine. All 11 patients were radiographically osteopenic. Ultimately, none of the patients had clinical evidence of neoplasm or infection involving the affected vertebral body. CONCLUSION: Recognition of the near-certain benign significance of a linear intravertebral gas collection revealed by radiography may prevent unnecessary imaging or biopsy in a patient with a suggestive vertebral compression deformity.

Aged↗
PubMed1997

Corporate concern.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1993

Gonadal teratomas: a study of 206 cases.

Total 206 gonadal teratomas were diagnosed in Christian Medical College and Hospital, Ludhiana from January 1980 to December 1990. 182 of them were in ovary and other 24 in testis. Majority of them i.e. 45.1% of ovarian and 45.8% of testicular lesions were seen in third decade. On gross examination 161 (88.4%) of ovarian tumours were cystic one (0.5%) was completely solid, while 20 (10.9%) showed solid as well as cystic areas. Majority (93.9%) of them were mature teratomas; 27 (14.8%) being dermoid cysts. In testicular lesions 22 (91.7%) were solid as well as cystic type and 2 (8.3%) were purely solid. Twenty (83.3%) of them were immature and only 4 (16.7%) lesions showed benign histology.

Adolescent↗
PubMed1991

Teratomas of rare sites: a review of ten cases.

Out of 267 cases of teratomas diagnosed in the department of pathology, Christian Medical College and Hospital, Ludhiana, Punjab from January 1980 to December 1989, 10 cases occurred in rare sites ie, 3 cases of teratoma in retroperitoneal space, 3 in the floor of the mouth, one each in mediastinum, thyroid, urinary bladder and kidney. None of these cases was clinically suspected as teratoma. One of the 3 teratomas of the retroperitoneal space and that of kidney were solid. Lesions of mediastinum and urinary bladder were solid as well as cystic. All these teratomas showed foci of immature elements. All other tumours were cystic and contained mature tissues only. Teratomas of the thyroid and kidney were treated with subtotal thyroidectomy and nephrectomy respectively, rest had surgical resection. One patient of immature retroperitoneal teratoma was lost to follow-up. All the others are alive and well for the period of 1 to 8 years. None had recurrence.

Adolescent↗