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Biomedical subjects

S Bien

Publications and source records attributed to S Bien.

51 records · Page 3Linked to original sources
PubMed1987

Nucleolysis and diskography--an experimental study on interaction of chymopapain and contrast medium.

A test was carried out on 11 young, full sized mongrels to determine whether there is an interaction between chymopapain and the contrast agents iotrolan and iopamidol. A total of 75 intervertebral disks were punctured: nucleolysis alone was performed on 20, diskography with iotrolan and subsequent nucleolysis on 20, and diskography with iopamidol and subsequent nucleolysis on 10. Diskography alone was performed 10 times with iotrolan and 5 times with iopamidol. Aqua dest. was given intradiskally 5 times, and puncture was carried out 5 times without the administration of any substance. Following puncture, x-rays of the lumbar vertebral column were taken laterally: daily for the first 10 days, then weekly. Disk space narrowing typical of nucleolysis with chymopapain was found among the disks that were nucleolyzed only to the same extent as among those that had undergone diskography previously. There was no evidence of narrowing of the other disk spaces which had been punctured but not treated with chymopapain. On some of the dogs, CT and MRI examinations were carried out. The CTs showed a homogenous hypodensity in all of the disks, in which chymopapain had been injected. The MRI revealed a signal loss in all of the nucleolyzed disks. The results of short and long term follow up demonstrate that inhibition of chymopapain by iotrolan or iopamidol is not to be expected and therefore diskography prior to chemonucleolysis can be performed without danger of enzyme inactivation.

Animals↗
PubMed1986

Magnetic resonance imaging of the cranio-cervical junction.

One hundred and thirty-three patients with a clinically suggested lesion of the cranio-cervical junction were investigated by magnetic resonance imaging (MRI). Based on pathologic findings in 68 cases, MRI is considered the diagnostic method of choice if a lesion of the cranio-cervical junction is expected. With this method it is possible to determine space-occupying lesions, and inflammatory, demyelinizing and degenerative changes. Only rarely contrast media are necessary in order to differentiate between tumor and tumor-edema.

Cervical Vertebrae↗
PubMed1986

Intracerebral cavernous angiomas in magnetic resonance imaging.

The findings obtained by magnetic resonance imaging (MRI) in 8 cases of surgically and histologically confirmed intracerebral cavernomas are reported. Six of the malformations were located temporally, one was located on the floor of the fourth ventricle, and one in the parietal lobe. All of the 8 cavernomas could be clearly demarcated, both in the T2 weighted image and in the spin density image. They are demonstrated as inhomogeneous zones with high or no signals. The tumors had irregular contours, which were clearly set off from the surrounding parenchyma. In 2 cases, the hemorrhage later detected surgically could already be assumed from the MR image. In 3 cases, zones with weak signals were found in the tumor, which were considered to be calcifications. One case of a vein with laminar flow could be established.

Adult↗
PubMed1986

[Neuroradiologic diagnosis and clinical aspects of giant intracranial aneurysms].

The CT and angiographic findings of 33 patients with intracranial giant aneurysms are reported. In the non-thrombosed giant aneurysms, CT showed a homogeneous, primarily hyperdense space-occupying lesion with strong enhancement. The partially thrombosed giant aneurysms appeared hyperdense with hypodense or isodense portions in the plain CT scan. The completely thrombosed giant aneurysms were isodense to hyperdense. In none of the 33 patients could perifocal edema be proved. A CT diagnosis was possible in every case of partially or non-thrombosed aneurysms. Pre-operative angiography in these cases was necessary only for purposes of vessel topography. Five completely thrombosed giant aneurysms could not be identified in either CT or the angiogram so that the diagnosis was not made until surgery. The clinical findings of these five cases of subarachnoid hemorrhage and 28 patients with signs of intracranial space-occupying lesions were diagnostically misleading, as they suggested an intracranial tumor.

Adult↗
PubMed1984

[Microvascular decompression of the trigeminal nerve - a causal therapy of trigeminal neuralgia?].

Preliminary experiences with the microvascular decompression of the trigeminal nerve within the cerebello-pontine angle ("Jannetta's operation") in ten patients are reported. All nine patients with typical tic douloureux were found to have a cross-compression of the nerve by the superior cerebellar artery. This vessel was separated from the nerve and held in place by a piece of Gelfoam. All nine patients were painfree immediately following surgery. Their sensation within the trigeminal area was unchanged compared to the preoperative state. The remaining patient suffered of atypical facial pain and did not reveal a cross-compression of the trigeminal nerve neither by an artery nor by a vein. Microvascular decompression seems to be a causal therapy in trigeminal neuralgia and is a non-destructive operation. Although our period of postoperative observation is short (up to five months), the results are very promising and correspond to the experiences reported by other authors. Advantages and disadvantages compared to the radiofrequency lesion (electro- and thermocoagulation) of the trigeminal nerve are discussed.

Humans↗
PubMedDate not supplied

[Vein of Galen malformation: prenatal diagnosis and noninvasive procedure].

In two fetuses a vein of Galen aneurysmal malformation was prenatally diagnosed causing cardiac failure and hydrocephalus associated with marked encephalomalacia. Blood flow in the vena prosencephalica measured by Doppler ultrasonography was extremely high (1290 and 1500 ml/min maximum). In a interdisciplinary council a strictly noninvasive pre- and postnatal procedure was proposed. After adequate information both parents agreed with this approach. The neonates died immediately after birth.

Cerebral Veins↗