Biomedical subjects
S Biggs
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Multiplication of tobacco mosaic virus in tobacco leaf disks is inhibited by (2'-5) oligoadenylate.
The oligonucleotide (2'-5') oligoadenylate that is induced in interferon-treated animal cells protects plant tissue from infection by the tobacco mosaic virus. This inhibition of virus multiplication was obtained at concentrations comparable to those affecting protein synthesis and antiviral activities in animal cells. After treatment with (2'-5') oligoadenylate, the multiplicability of tobacco mosaic virus was reduced by 80 to 90 percent as measured by enzyme-linked immunosorbent assay. These results, along with the observation that human interferon protects tobacco tissue from infection by tobacco mosaic virus, indicate that plants and animals may have a common pathway for virus resistance.
Interpretations of nonstress tests by obstetric nurses.
Five 20-minute nonstress-test strips were mailed to 1,000 members of NAACOG--the organization for obstetric, gynecologic, and neonatal nurses. The individuals were selected systematically from NAACOG's 10 districts. For the 412 (41%) respondents, at least 84% of the answers concurred on each of the five strips. The majority opinion was taken to be the correct answer. Concurrence with the majority was independent of clinical experience, clinical training, and the extent of present nonstress-test responsibilities. The same five strips were interpreted by obstetricians in a previously reported survey. On a two-point, reactive-nonreactive scale, the sample of obstetric nurses' degree of agreement differed significantly from the sample of physicians' degree of agreement (92 versus 98%) on only one strip.