[Use of kallikrein in the treatment of oligoasthenospermia].
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Biomedical subjects
Publications and source records attributed to S Bila.
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On the basis of the results of the analysis of FSH, LH, and prolactin values in the serum of patients with secondary ammenorrhea, four groups of patients were formed: group 1 with low values of both gonadotropin hormones, group 2 with low FSH and high LH values, group 3 with high FSH and high LH values, and group 4 with the basdal gonadotropin values within normal. The use of functional tests proved helpful in the differentiation of the causes of amenorrhea. The use of the LH-RH test is of particular significance in the differentiation of the degree of changes in patients from group 1 and 4. To determine adequate therapy, the determination of estrogen in patients from group 1 and 3 is imperative. A successful treatment of secondary amenorrhea depends on its duration and a timely detection of its causes.
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A randomised group of 75 men with idiopathic oligoasthenozoospermia and asthenozoospermia were subjected to control study with kallikrein. Kallikrein was given to 45 men 600 units daily in a period of 3-6 months. The other group of 30 infertile men was followed during the same period of time. Percentage of motile sperm was significantly improved after 3-6 months treatment with kallikrein. Sperm count and percentage of morphologically normal sperm showed improvement but was not statistically significant. Infertile men with sperm count below 20 X 10(6)/ml had greater improvement in sperm count than men with sperm count over 20 X 10(6)/ml. This study emphasizes that kallikrein is a relatively good drug for restoring sperm motility in idiopathic oligoasthenozoospermia and asthenozoospermia.
The serum SHGB (sex-hormone-binding globulin) concentration was measured in patients with secondary amenorrhea in order to determine its role in the regulation of androgen and estrogen metabolism in the course of the normal and irregular menstrual cycle. SHBG concentration was lower than in the control group in 52% of amenorrheic patients, but this difference was not statistically significant due to great individual variations. If the patients were divided in 2 groups according to Prolactin (PRL) concentration, significant decrease in SHGB concentration was observed in the group with elevated PRL concentrations. Correlation of SHBG with estrogen (E2), testosterone (T), progesterone (PRG) and PRL was tested and results show the weak correlation (r = 0.4) between SHGB and T and more significant correlation between SHGB and E2 in the group with basal E2 concentration below 100 pmol/1. SHGB test should be included in the evaluation of alterations of androgen and estrogen metabolism.
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