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Biomedical subjects

S Blackburn

Publications and source records attributed to S Blackburn.

At least 19 recordsLinked to original sources

Panum's limiting case: double fusion, convergence error, or 'da Vinci stereopsis'.

Panum's limiting case--a perceived depth difference between two lines in one eye combined with only one in the other eye--has long been considered weak or reversible. In the last few years this has led to strong promotion of the view that Panum's case is not based on a stereoscopic process involving double fusion, that only one line is fused, with the depth of the other one attributable either to fixation disparity or to occlusion cues. This view is refuted in two ways. First it is shown that when the separation of the two lines, considered as a disparity, is within the range of 'patent stereopsis', depth is perceived with a precision and accuracy indistinguishable from regular stereopsis. The predictions of nonstereoscopic theories concerning the effects of fixation are not borne out at small disparities. Second, very compelling Panum versions of orientation and curvature disparity are introduced, which are difficult to account for except by a process of double fusion. Finally it is shown that at large disparities the depth in Panum's case deviates from prediction more frequently than does regular stereoscopic depth.

Convergence, Ocular

Problems of preterm infants after discharge.

Preterm infants often experience continuing health problems after discharge and have a higher rate of readmittance to the hospital during the first year. These infants also are at risk for neurodevelopmental problems, such as language, learning, and school difficulties. The continuing health and developmental problems of preterm infants creates stress for the family. Nurses caring for these infants in hospital settings must understand the problems for which preterm infants are at risk after discharge as a basis for appropriate discharge planning and teaching. A similar knowledge base will help nurses working in community settings in assessment and interventions with infants and their families after discharge.

Developmental Disabilities

Hyperbilirubinemia and neonatal jaundice.

Jaundice is a common physiologic problem seen in both term and preterm infants. Normal transitional changes in bilirubin metabolism lead to physiological jaundice in many infants. In some infants these normal changes at birth may be exaggerated, such as occurs with immaturity, or may interact with health alterations (pathologic jaundice), resulting in the accumulation of excess bilirubin and development of hyperbilirubinemia. Caregivers must appreciate the processes and the basis for physiologic jaundice and hyperbilirubinemia and recognize infants at risk for these disorders. This article reviews neonatal bilirubin metabolism as a basis for understanding the causes and treatment of physiologic jaundice and hyperbilirubinemia arising from either physiologic or pathologic causes. Patterns of bilirubin in breast fed infants are discussed along with other issues related to breast feeding and jaundice. Treatment of hyperbilirubinemia and implications for nursing assessment and management of infants under phototherapy are also described.

Breast Feeding

Interrater agreement for diagnosis of Alzheimer's disease: the MIRAGE study.

There are standardized criteria to assist in the diagnosis of Alzheimer's disease (AD), a disorder that lacks unique clinical, morphologic, or biochemical features. Diagnostic reliability of single groups of investigators using these criteria is moderate to substantial. In this study, seven clinicians at separate sites established a criteria-based diagnosis in 42 consecutive memory disorder patients participating in a national genetic epidemiologic study using a quantitative multiaxis AD rating scale (ADRS) that incorporates NINCDS/ADRDA criteria, reliability of information, and comorbidity. Reliability, measured by a generalized kappa statistic for more than two raters, was substantial (0.63 +/- 0.13) when the subjects were grouped as "AD" (probable or possible) versus "not AD," but somewhat lower (0.52 +/- 0.10) when subjects were classified as probable AD, possible AD, or not AD. There was unanimous agreement for two-thirds of the subjects using a dichotomous classification scheme. These findings suggest that the ADRS is a useful diagnostic instrument for multicenter studies.

Alzheimer Disease

Dinoflagellate Gymnodinium catenatum as the source of paralytic shellfish toxins in Tasmanian shellfish.

Paralytic shellfish toxins in both cultured cells and natural phytoplankton blooms of the dinoflagellate Gymnodinium catenatum from inshore Tasmanian waters (Australia) were analyzed by high performance liquid chromatography, thin layer chromatography and electrophoresis techniques. The dinoflagellate toxins were dominated by low potency sulfocarbamoyl saxitoxin derivatives (98-99 mole% in total), including gonyautoxin VIII (C2) and its epimer (C1) and sulfocarbamoyl gonyautoxins I and IV (C3 and C4). Mussels and oysters contaminated by the dinoflagellate showed similar toxins, but contained larger proportions of C3 (40-57 mole%) and more potent carbamate toxins (7-23 mole% total).

Animals

Biosynthesis of polyamines in ornithine decarboxylase, arginine decarboxylase, and agmatine ureohydrolase deletion mutants of Escherichia coli strain K-12.

Escherichia coli K-12 mutants that carry deletions in their genes for ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) (speC), arginine decarboxylase (L-arginine carboxy-lyase, EC 4.1.1.19) (speA), and agmatine ureohydrolase (agmatinase or agmatine amidinohydrolase, EC 3.5.3.11) (speB) can still synthesize very small amounts of putrescine and spermidine. The putrescine concentration in these mutants was found to be 1/2500th that in spe+ cells. The pathway of putrescine synthesis appears to be through the biodegradative arginine decarboxylase, which converts arginine to agmatine, in combination with a low agmatine ureohydrolase activity--1/2000th that in spe+ strains. These results suggest that even such low levels of polyamines permit a low level of protein synthesis. Evidence is presented that the polyamine requirement for the growth of the polyamine-dependent speAB, speC deletion mutants, which are also streptomycin resistant, is not due to a decreased ability to synthesize polyamines.

Bacterial Proteins

Making a case for studying the ecologic niche of the newborn.

A major focus of theory building in nursing relates to further conceptualization of human-environmental interaction and multidimensional systems that support or do not support health. There is a growing body of knowledge regarding the newborn and his skills, and the transactions and interactions between the newborn and his environment. The newborn cannot be considered in isolation from his environment for it is this interaction with the environment that provides opportunities for organization of his behavior, physiologic functions, and regulatory processes. The caregiving environment and the newborn's interactions with this environment form the ecologic niche of the newborn; one that will enhance or impede the infant's behavioral differentiation and organization, early adaptations, later development, and the infant's interactions with his parents and other caregivers.

Adult

Assessment of change-agent expectations in reversal-to-baseline designs.

Questionnaires similar to those used in previous research to assess behavioral expectations produced by differing reversal-to-baseline rationales were presented to 160 male and female parents in rural South Dakota. Given two case histories, respondents were asked to predict, as simulated change agents, the frequency of problem behavior during reversal in an ABAB design intervention. The five rationales for reversal were: (a) withdrawal, (b) withdrawal and counter-expectancy, (c) problem switch and counter-expectancy, (d) fade and counter-expectancy and (e) inert treatment and counter-expectancy. While obtained means were close to those of a previous study, there were no significant sex or treatment effects. This fails to confirm the earlier results obtained from university undergraduates. Implications for internal validity of ABAB designs are discussed.

Adult