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Biomedical subjects

S Block

Publications and source records attributed to S Block.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Necrotizing pancreatitis: peritoneal lavage or bursa lavage? Results of a prospective consecutive controlled study].

In 111 patients with necrotizing pancreatitis two different therapeutical procedures were applied since 1974 in addition to the surgical removal of necrotic tissue. In group I with 64 patients a continuous peritoneal lavage and in group II with 47 patients a local lavage of the lesser sac were performed. In case of extrapancreatic necroses and diffuse peritonitis peritoneal lavage was done additionally in 32 patients. Local lavage of the lesser sac, in some cases combined with peritoneal lavage, is the procedure significantly superior to peritoneal lavage alone.

Acute Disease↗
PubMed1985

[Morphologic and functional changes in the pancreas following acute necrotizing pancreatitis].

Acute necrotizing pancreatitis according to the presented results leads to definite endo- and/or exocrine functional loss in 57% of the patients (n = 21, pancreatic necrosis ascertained by laparotomy) evaluated by orale glucose tolerance test, secretin-ceruletide-test and fluorescein-dilaurate-test. Morphological alterations developed in 76% of patients, predominantly cicatricial ductal lesions shown by ERCP. The finding of a normal pancreatic function after extended necrosis in 43% of the patients can be explained by the enormous functional reserve of the pancreatic gland.

Acute Disease↗
PubMed1984

[Duodenum-sparing pancreas head resection in chronic pancreatitis--results after 10 years' use].

During a ten years period duodenum preserving pancreatic head resection was performed in 56 patients with chronic pancreatitis and related pancreatic head tumor. Immediate lethality was 1.8%, rate of reoperation 3.6%, late lethality after an average follow-up of 24 months (minimum 1, maximum 124 months) 3.6%. At the time of follow-up 87.3% of the patients were back at work, 58% were free of abdominal symptoms, 7.4% complained about occasional to frequent abdominal pains. 72.9% gained weight postoperatively. Duodenum preserving pancreatic head resection constitutes the subtotal resection of the pancreatic head and jejunal interpostition for the parenchymal defect. The procedure is advantageous as compared to Whipple's operation in so far as stomach, duodenum and bile duct remain intact.

Adult↗
PubMed1982

[Necrotizing pancreatitis. Surgical indications and results in 118 patients].

In a ten years period 118 patients were operated with necrotizing pancreatitis. 42% of the patients had a 50% necrosis and 25% a subtotal/total necrosis of the pancreas. Surgical therapy principally includes: necrotectomy with drainage of the pancreas layer and postoperatively local lavage of the pancreatitic cavum (61/24 h). In 28 patients a continuous peritoneal lavage were performed additionally (24.4 +/- 14.71/day, duration 9.6 +/- 8.2 days). The total lethality was 33.9%. The course of the patients with necrotizing pancreatitis is destinated by the extention of the necrosis in the pancrease itself, the development of extrapancreatic necrosis and the bacterial contamination of the necrosis (bacterial retroperitonitis, abscess).

Acute Disease↗
PubMed1979

Sterilization of laparoscopes. Is soaking sufficient?

Controversy exists over the proper methods of sterilizing laparoscopic telescopes. An edict requiring gas sterilization rather than solution soaking of these instruments is in force in all federal hospitals. This rule has necessitated capital investments for new instruments and has led to a severe reduction in the number of cases of laparoscopy that may be scheduled in one day. Fear of contamination is based on theoretical considerations and rusn counter to the actual, observed safety record seen with laparoscopes soaked in activated glutaraldehyde between cases. In an effort to dispassionately approach this problem, cultures of the umbilical area, the laparoscope and the pelvic serosal surfaces were taken to document the type of organisms commonly encountered under clinical conditions. Cultures for aerobic and anaerobic bacteria as well as for fungi were taken after soaking the telescope in activated glutaraldehyde. The results demonstrated growth of common skin organisms even after skin preparation with povidone-iodine and ethyl alcohol. Similar organisms were recovered in some cases from the laparoscope and the pelvic surfaces. The actual degree of contamination suggested by a colony count falls well within the range of the healthy peritoneum to cope with these organisms. Recommendations for laparoscopic sterilization or disinfection are based on the results obtained.

Ascitic Fluid↗
PubMed1976

Bedside hemodynamic monitoring. Its value in the diagnosis of tamponade complicating cardiac surgery.

Cardiac tamponade may be a difficult clinical diagnosis in the early postoperative period in patients undergoing open-hear surgery, particularly when the anterior or lateral pericardium is left open. Bedside monitoring of intracardiac pressures and determination of a "pressure plateau" between right atrial, right ventricular diastolic, pulmonary arterial diastolic, and pulmonary capillary wedge pressures are useful in the early diagnosis of cardiac tamponade. The value of such hemodynamic monitoring in the diagnosis and treatment of cardiac tamponade in three patients with aorta-coronary artery bypass surgery in the early postoperative period is reported. Appropriate therapy, carried out on the basis of these studies, minimized the occurrence of further morbidity or possible death.

Adult↗
PubMed1968

Host-controlled restriction of T-even bacteriophages: relation of four bacterial deoxyribonucleases to restriction.

Escherichia coli strains B and K-12, which restrict growth of nonglucosylated T- even phage (T(*) phage), and nonrestricting strains (Shigella sonnei and mutants of E. coli B) were tested for levels of endonuclease I and exonucleases I, II, and III, by means of in vitro assyas. Cell-free extracts freed from deoxyribonucleic acid (DNA) were examined with three substrates: E. coli DNA, T(*)2 DNA, and T2 DNA. Both restricting and nonrestricting strains had comparable levels of the four nuclease activities and had similar patterns of preference for the three substrates. In addition, mutants of E. coli B and K-12 that lack endonuclease I were as effective as their respective wild types in restricting T(*) phage.

Coliphages↗
PubMedDate not supplied

Cell-mediated immunity in rheumatic diseases. II. Mitogen responses in RA, SLE, and other illnesses: correlation with T- and B-lymphocyte populations.

Lymphocyte responses to phytohemagglutinin, concanavalin A, and pokeweed mitogen were tested in normal patients and in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), scleroderma (PSS), other connective tissue disease, and other illnesses. The relationship of lymphocyte response to diagnosis, therapy, and T- and B-lymphocyte populations was analyzed. Additional studies included the determination of proliferative responses of various combinations of purified T and B lymphocytes cultured with plant mitogens. Lymphocytes from patients with RA and SLE incorporated significantly less thymidine in the presence of plant mitogens as compared to normal and comparably ill subjects. Treatment had no effect on mitogen response. Responses to all three mitogens correlated closely in patients with RA, SLE, or PSS; no correlation was noted between the response to mitogen of lymphocytes in culture and the number of T cells cultured.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Managing patient demographics.

The Harvard Community Health Plan commissioned a cross-functional project team to improve the accuracy of the members' data base because inaccurate patient phone numbers and addresses were a major obstacle for clinicians seeking to provide high-quality service to patients. Accurate demographic information is essential to enable clinicians to contact patients quickly regarding lab results or follow-up care. The team members applied a quality improvement problem-solving methodology that required them to focus on the few vital problems and to test problems using data analysis. As a result, the team saw firsthand that staff members were not to blame for the inaccurate demographic information; the problem was in the automated system that obtains, updates, and maintains the records.

Ambulatory Care Information Systems↗