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Biomedical subjects

S Bonazzi

Publications and source records attributed to S Bonazzi.

4 recordsLinked to original sources
PubMed1997

Synthesis and binding properties of conjugates between oligodeoxynucleotides and daunorubicin derivatives.

Conjugation of an anthracycline to a triplex-forming oligonucleotide (TFO) allows delivery of this drug to a specific DNA site, preserving the intercalation geometry of this class of anticancer agents. Conjugate 11, in which the TFO is linked via a hexamethylene bridge to the O-4 on the D ring of the anthraquinone moiety, affords the most stable triple helix, through intercalation of the planar chromophore between DNA bases and binding of both the TFO and the amino sugar to the major and the minor groove respectively.

Antibiotics, Antineoplastic↗
PubMed1996

Acquired dysgraphia with selective damage to the graphemic buffer: a single case report.

We describe one patient with acquired dysgraphia who showed spelling errors (mainly deletions and substitutions), both for words and non-words, across all output modalities (oral and written spelling, and delayed copying). Spelling accuracy was not affected by lexical factors, but was a function of word length. The patient's performance in oral and written tasks suggests the hypothesis of selective damage to the Graphemic Buffer.

Agraphia↗