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Biomedical subjects

S Bondestam

Publications and source records attributed to S Bondestam.

At least 73 records · Page 4Linked to original sources

Sonography and computed tomography in hepatic haemangioma.

Seven patients suffering from hepatic haemangioma were investigated by sonography and computed whole-body tomography (CT). In addition, percutaneous fine-needle biopsy was performed in 3 cases. All the patients had typical angiographic features of hepatic haemangioma. Histological confirmation was obtained in five cases. Sonography showed lesions of sonodense and mixed predominant sonolucent features. CT showed typical peripheral post-contrast enhancement. Fine needle biopsy was successful and diagnostic in two cases. No complications occurred with the procedure. Sonography overlooked one tiny lesion, and CT two. It seems that sonographic appearances are not reliable in the diagnosis of hepatic haemangioma, though CT may be diagnostic. In doubtful situations other diagnostic procedures, such as angiography and/or fine-needle biopsy, may be necessary.

Adult↗

Urgent real-time cholecystosonography in suspected acute cholecystitis.

Acute cholecystitis was suspected in 60 patients. Correct diagnoses were achieved by urgent real-time cholecystosonography in all the 38 patients that had acute cholecystitis. In about one-third of the other cases sonography revealed the pathological states responsible for the symptoms simulating those of acute cholecystitis. All of the examinations were technically satisfactory.

Acute Disease↗

Screening for urinary tract abnormalities with single-film urography after phlebography and angiography.

Single-film urography was performed after phlebography or angiography in 2,335 patients. Abnormal results were reported in 52 of these patients. Subsequent complete urography verified two significant abnormalities (one renal calculus and one renal cell carcinoma). In addition, there were 28 less significant abnormalities. In 22 patients the single-film urography was incorrectly reported as abnormal. Among the 2,283 normal single-film studies there were three cases of false-negative results (two renal cell carcinoma and one renal calculus with perinephritis). This study does not confirm the value of routine single-film urography after phlebography and angiography.

Adenocarcinoma↗

Ultrasound examination and cholescintigraphy in cholestasis.

The results of ultrasound, cholescintigraphy, and their combination, were analysed in 57 patients with cholestasis. At ultrasound, the presence of an extrahepatic obstruction was correctly diagnosed in 13 and at cholescintigraphy in 14 of 18 cases. The correct diagnosis increased to 17 when the information was combined. In the 31 patients with intrahepatic disease, absence of extrahepatic obstruction was correctly predicted in 26 cases with either method alone, whereas the combined use yielded a correct result in 29.

Adolescent↗

Ultrasound guided fine-needle biopsy of mass lesions affecting the hepatobiliary tract.

Ultrasound guided fine-needle biopsy of mass lesions affecting the hepatobiliary tract in 67 patients is reported. A free-hand approach was used without a special biopsy transducer. All aspirates were sufficient and relevant. A correct cytologic diagnosis was reached in 91 per cent of the 57 malignant cases. In addition, malignancy was correctly suggested in 5 cases. In 33 per cent of the cases with unknown primary tumor, cytology determined the origin of the malignancy. No complications occurred.

Adult↗

Sonographic diagnosis of primary carcinoma of the gallbladder. Summary of one year's examinations.

The material of 1 year's sonographic examinations of the gallbladder region have been analyzed for diagnosis of gallbladder carcinoma in a prospective study from a large hospital. Of 11 cases diagnosed sonographically 6 were proved corrected by surgery or autopsy; 5 were false-positive results. In addition, there was 1 false-negative diagnosis. In 3 sonographically diagnosed cases fine-needle aspiration biopsy of suspected liver infiltration gave 2 positive and 1 false-positive result. Sonography can suggest the diagnosis of gallbladder carcinoma, but inflammatory changes in the gallbladder may simulate or mask the signs of malignancy.

Aged↗

Angiographic work-up in a patient with late vaginal metastasis from a renal carcinoma.

Vaginal metastasis from a renal cell carcinoma appeared 23 years after the primary surgery in a 64-year-old female. At angiographic work-up local recurrence in the renal fossa and liver metastasis were demonstrated. These findings indicated radiation treatment instead of radical surgery of the vaginal metastasis, which primarily was though to be solitary. Angiography and/or computorized tomography (CT) of the retroperitoneal space and the liver should be performed in patients with late and presumed solitary metastasis from a renal cell carcinoma before radical surgery of the metastasis is attempted.

Adenocarcinoma↗

Intravenous cholegraphy and ultrasonography in examination of orally nonfilled gallbladders.

The efficacy of intravenous cholegraphy (IVC) and gray-scale ultrasonography (US) in detecting the presence or absence of gallstones was evaluated in 54 patients with orally nonfilled gallbladders. The IVC finding was diagnostic in 26 cases (48%), of which 19 were normal and 7 had gallstones. The respective figures by US were 48 (89%), 18 and 30. In 3 cases only IVC was diagnostic and in 25 cases only US. US was considered to be the method of choice for the secondary examination of an orally nonfilled gallbladder. IVC is justified as a secondary examination if US is not available and is indicated as the tertiary examination if US fails or if a clinical suspicion of gallbladder disease remains after a normal US finding.

Adult↗

Combination of multiple pencil-beam imaging to computed storage phosphor radiography: a new method.

Computed radiography (CR) with storage phosphors offers a wide dynamic range and improved sensitivity compared to film-screen technology. CR was combined in this study with a prototype multiple pencil-beam (MPB) imaging device which has been shown to be very effective in scatter reduction. The combination was analyzed and compared to the standard technique of grid screening in two ways: a free-response ROC (FROC) analysis was first performed followed by a blinded test arrangement for visual analysis of image quality in a series of computed radiography of the lumbar spine by both the MPB and grid modalities. The results of the FROC study showed a statistically significant (P less than or equal to 0.01) improvement in signal detection. The MPB-CR images of the lumbar spine had more contrast but also a slightly mottled or grainy appearance. Image quality was found good but contrast processing was criticized because it seemed to result in a too steep display of contrast in MPB imaging. This should be avoidable by changing the image processing parameters.

Adult↗

User discipline in a personal computer-based filing of ultrasound records.

The discipline of entering ultrasound examination data in a personal computer file was studied over two periods. During the first period (19 weeks), the use of the computer was limited to one laboratory. During the second period (14 weeks), the computer was shared by three laboratories operating in nearby premises. During the study, 2857 (89%) of a total of 3209 ultrasound examinations performed were duly recorded in the data file. The frequency of failure to enter data was markedly higher during the second period (7-45%) than during the first period (5%) of the study. Overall, there was a highly significant (p less than 0.001) tendency to enter pathological findings at the expense of normal and non-diagnostic findings. The ease of access to the computer and the number of examinations recorded appear to determine user conscientiousness in filing data. Selection and omission of data impair the usefulness of the data log in research.

Humans↗

Detection of focal liver lesions with superparamagnetic iron oxide: value of STIR and SE imaging.

OBJECTIVE: We assessed the value of superparamagnetic iron oxide (SPIO) particles on the detection of focal liver lesions by MRI. MATERIALS AND METHODS: Twenty patients with one to five focal liver lesions, primarily detected with ultrasonography and/or contrast-enhanced CT, were evaluated further with unenhanced and iron oxide-enhanced MRI at 1.0 T. Superparamagnetic iron oxide particles were administered intravenously as a slow infusion. Then T1-, T2-, and proton density-weighted SE images were obtained. In addition, the performance of a short TI inversion recovery (STIR) sequence was evaluated. RESULTS: The iron oxide contrast medium had marked effects on liver signal-to-noise (S/N) and tumor-to-liver contrast-to-noise (C/N) ratios but only minimal effects on tumor S/N ratios in cases of malignant tumor foci. Lesion-to-liver contrast, expressed as differences between the tumor and liver S/N ratios, improved very significantly after SPIO infusion with all four pulse sequences. Contrast enhancement of the liver parenchyma was best in T2-weighted SE images, but the tumor-to-liver C/N values were highest with the postcontrast STIR sequence. The SPIO enhancement revealed a number of additional focal lesions (31%), also foci under 1 cm in diameter. In three benign focal lesions, SPIO infusion produced a definite reduction in the S/N ratio of the lesions in contrast to the minimal change measured in malignant foci. The favorable performance of the STIR sequence contradicts the disappointing results previously obtained at 0.6 T. CONCLUSION: Superparamagnetic iron oxide is a promising new contrast medium for MR examinations of the liver, increasing the conspicuity and reducing the detectability threshold of focal hepatic lesions.

Adult↗