Study of motor and sensory nerve conduction in the femoral nerve in the newborn and in the adult.
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Biomedical subjects
Publications and source records attributed to S Borenstein.
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Three different interfering conditions were studied during the recording of pre- and postcentral somatosensory evoked potentials (SEPs) following median nerve stimulation at the wrist in 16 normal subjects: active finger movement (MVT), light superficial massage (LSM) and deep muscular massage (DMM) of the hand. Special attention was focused on selective effects on individual SEP components. The frontal N30 component showed the most significant amplitude reduction during the three interfering conditions (76.4% of reduction in MVT, 36.4% in DMM and 32.9% in LSM). In contrast the frontal N23 was not significantly changed and the preceding P22 component was only reduced in the MVT condition. Postcentral N20 was unchanged by the three conditions while P27 was clearly gated by movement but not significantly by LSM and DMM. The three interfering conditions enhanced the parietal N32 and had no significant effect on the parietal P45. An important point was the interindividual variability of these effects and it appeared that group average wave forms would therefore be confusing. The peak latency of some SEP components was changed during the interfering conditions. The most important effect was an increase of postcentral P45 latency which was found to be related to the amplitude enhancement of N32.
It is known that somatosensory evoked potentials can be influenced by several centripetal and centrifugal factors which modify their amplitude. The present study shows for the first time that the frontal waves N30 and to a lesser extent N23 are specifically attenuated during mental movement simulation (MMS) activity. This gating phenomenon, tested on 16 normal subjects, occurred when repeated fast finger movements on the stimulated side are mentally simulated. In contrast, no significant modification appeared when the subject performed the MMS activity with the hand contralateral to that receiving electrical stimuli or when the subject performed a mental operation unrelated to the MMS. The MMS was shown by Roland et al. (1980) to increase the regional blood flow exclusively in the supplementary motor area (SMA). Our experimental data therefore indicate that the SMA could play an important role in the generation of the frontal N30.
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Because of the nature and location of the lesion in central pontine myelinolysis, considerable difficulties in diagnosis may arise. Computed tomography (CT) and brainstem auditory-evoked potentials are useful in following the spread and regression of the pontine lesion. The correlation between clinical evolution, serial CT scans, and brainstem auditory-evoked potentials is considered in a patient with central pontine myelinolysis and subsequent complete recovery with special emphasis on the evolution of the CT scan after recovery.