Biomedical subjects
Publications and source records attributed to S Bretz.
A tumor is reported which originated rom an osteoma cutis and expanded into the surrounding tissue by infiltration and destruction. Histologically, there were no signs of malignancy. In cell culture there grew populations of bone-like tissue with highly active metabolism and negative contact inhibition. Therapeutic trials with diphosphonate are discussed.
The modified leucocyte-longterm culture is presented as adequate procedure for demonstration of tumor cells from peripheral blood of melanomalignoma patients. By means of the proliferation cinetics, an exact differentiation between tumor cells on one side, and melanophages, so called irritated monocytic forms and endothelial cells on the other side is possible. In this in vitro-system proliferative tumorcells from peripheral blood can be differed from non-proliferative ones. The interaction between tumor cells, macrophages and lymphocytes is reported.
A new routine-method is presented for the morphokinetic documentation of autoimmunologically induced processes in vitro via leukocyte long-term culture (LLC). The prominent rosette-sheeped autologous lymphocytes in deposition at central granulocytes are well defined. These autologous rosette-formations in LLC rank very high in diagnosis of autoimmundiseases, since this phenomenon is positive already, while the results of current methods in routine-serumexaminations are still negative. Presenting a case of discoid Lupus Erythematodes this well developed method is represented in early recognition of dermatological autoimmundiseases, while cellular cinetics are discussed.