Biomedical subjects
Publications and source records attributed to S Budu.
A case of malignant anorectal melanoma is reported, which was treated by anorectal-sigmoid amputation, operation which did not prevent the occurrence, after 6 months, of metastases in the inguinal lymph nodes. On the basis of the reported case, the main etiological, histogenetic, prognostic and therapeutic aspects of these rare tumours are discussed.
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The authors present the case of a female patient aged 19 years with chorionepithelioma, multiple pulmonary metastases, and an unique intestinal metastasis, complicated by severe digestive haemorrhage and haemoperitoneum. Surgery was carried out in risky conditions and consisted in segmental enterectomy and subtotal hysterectomy, and bilateral adnexectomy. The postoperative evolution was unsatisfactory, and the patient died following continued digestive bleeding, probably due to coagulation disturbances induced by prolonged loss of blood. Although the disease is encountered and treated in ob-gyn departments, the general surgeon can be confronted by such complications of this affection which may take on extremely severe aspects, and where surgery, provided that is performed sufficiently early, can save the patient's life.
The enteroendocrine cells were studied in rats from one day to two years of age. A gradual increase in the number of argentaffin granules and cell volumes paralleling the ageing was observed. The volumes of argentaffin cells in rats reached a maximum at 9 months and decreased towards two years. The argentaffin cells of the intestine are significantly larger than the gastric ones. No significant correlation was found between argentaffin granules number and cell volumes and the gastric or duodenal ulcers. A slight hyperplasia of enteroendocrine cells around the gastric ulcers was noticed.
The authors present 7 cases of acute non-lithiasic cholecystitis, representing 1.5% of the total number of acute cholecystitis cases in their personal statistics. The determining factor of the acute inflammatory process of the gallbladder was represented in 6 of the cases by non-lithiasic obstruction of the cystic duct. In the last case there was acute segmental cholecystitis secondary to a gallbladder septum, probably of congenital origin. Clinical and anatomo-pathological aspects are discussed, of acute non-lithiasic cholecystites, the origin of which is located in the diverticular apparatus of the biliary pathways. From the therapeutical viewpoint cholecystectomy is the most indicated attitude in such cases.