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S Buller

Publications and source records attributed to S Buller.

5 recordsLinked to original sources

Skilled nursing practice -- a qualitative study of the elements of nursing.

An understanding of skilled nursing practice has implications for the identity of nursing in service delivery, and for the learning environment of the developing nurse. Here I report a qualitative study, largely reliant on ethnography, which became a journey of exploration through accounts and descriptions given by nurses in a number of different practice settings. This journey is founded in an understanding of what I have called a phenomenological and psychosocial tradition, recognising the importance of a postmodern influence, which is in tension with a scientific and behavioural tradition. The emergence of four domains of skilled nursing practice in a contextualised narrative would seem to offer justification of assumptions concerning the value of embedded knowledge and intuitive clinical judgement in nursing practice, and lay a foundation for a qualitative study of the developing nurse.

Adaptation, Psychological↗

Bisquaternary caracurine V derivatives as allosteric modulators of ligand binding to M2 acetylcholine receptors.

The allosteric effect on muscarinic acetylcholine M2 receptors of 11 bisquaternary salts of the Strychnos alkaloid caracurine V was determined. The effect was indicated by the concentration which retarded the rate of dissociation of the antagonist [3H]-N-methylscopolamine from porcine cardiac cholinoceptors by a factor of 2 (EC50). The most potent compounds carry allyl and propargyl substituents, respectively. Introduction of more bulky substituents (e.g., benzyl groups) resulted in a considerably reduced allosteric potency. The wide range of EC50 values (3 nM for R = allyl. 1750 nM for R = 2-naphthyl) suggests a sterically restricted binding pocket. Molecular modeling studies indicated that the caracurine V ring system satisfies the pharmacophore model for the allosteric interaction.

Alkaloids↗

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Community Mental Health Services↗