The previously reported release of arachidonic acid by THC has now been demonstrated in murine Leydig cells and WI-38 human lung fibroblasts showing the generality of the effect. The release reaction could be antagonized by phospholipase A2 inhibitors such as quinacrine and quinine, suggesting that THC can stimulate the activity of this enzyme. Further evidence for this possibility was obtained by demonstrating the release effect on a subcellular fraction which contained the phospholipase A2 activity. The stimulation of this enzyme could have profound effects on prostaglandin synthesis and/or on the integrity of various membrane structures.

Animals↗

PubMedDate not supplied

Observations on an effect of ACTH, dexamethasone, and dimethyl sulfoxide on the "out of strain" transplantation and lethality of strain 2 guinea pig leukemia L2C-NB to strain 13 and Hartley animals.

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Adrenocorticotropic Hormone↗

PubMedDate not supplied

Normal aortoiliac diameters by CT.

In spite of the vital role CT plays in the evaluation of vascular disease, no standard CT derived dimensions for the abdominal aorta, iliac, and femoral arteries have been established. A retrospective study of the CT scans of 260 patients was performed with patients separated by sex and age. Aortic diameter was measured at predetermined suprarenal, renal, and infrarenal locations and single measurements of the iliac and femoral arteries were made bilaterally. The vessel diameter was observed to gradually increase with age in both sexes. Men were found to have larger diameter vessels than age matched women. This pattern was noted at all levels measured. The normal range of vascular dimensions determined is presented.

Adult↗

PubMedDate not supplied

Caloric restriction for 24 hours increases mean night growth hormone.

UNLABELLED: In obesity, serum growth hormone (GH) is usually low, confounding GH assessment of short obese children. We evaluated whether 24-h caloric restriction would permit better discrimination between normal GH secretion and GH deficiency (GHD) by elevating night GH levels. DESIGN AND PATIENTS: Serum was obtained every 20 minutes 2000-0800 h before and 2200-0400 h after 24 hours of caloric restriction (8% of usual calories) in 24 normal height children [14 normal (weight for height 10-90th percentile); 10 obese (weight for height > 95th percentile)] and in 31 short children (height shorter than -2.0 SD below mean for age). All samples from both nights per child were assayed for GH simultaneously to eliminate interassay variability. RESULTS: Mean GH increased significantly in all groups after caloric restriction (P < 0.01). Obese children had lower baseline mean GH and GH amplitude compared to normal (P < 0.01); GH increased into normal range after restriction. Basal GH studies in short children were not significantly below normal. Surprisingly, some with low stimulated GH increased their night GH into the normal range after caloric restriction. CONCLUSIONS: Caloric restriction for 24 h enhances night GH similarly in short and in normal children, and thus does not increase the diagnostic utility of night GH studies in non-obese short children. Caloric restriction reverses suppressed GH secretory state of obese children, perhaps by decreasing diet-dependent somatostatin inhibition of GH secretion.

Adolescent↗