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S Bydder

Publications and source records attributed to S Bydder.

17 recordsLinked to original sources
PubMed2006

The value of a scientific writing training workshop for radiologists and radiation oncologists.

A substantial amount of radiological and radiation oncological research carried out in Australasia is not published. Therefore, a scientific writing skills training workshop was held in conjunction with the 2004 Royal Australian and New Zealand College of Radiologists Annual Scientific Meeting. Registration for the 3-h-long workshop was open to all conference attendees but numbers were limited. The workshop was led by an experienced facilitator who used content based on a literature review. Participants were asked to complete questionnaires rating their agreement with statements regarding their writing abilities and resources before the workshop. Those who attended the workshop repeated the questionnaire 6-8 weeks afterwards. Comparison of the paired preworkshop and postworkshop responses showed increases in the median category of agreement with statements regarding having the required skills, having advice available and understanding the structure of scientific articles. In addition, all participants reported that they found the workshop useful, said that they would recommend attendance to others and felt that such workshops should be available at future Royal Australian and New Zealand College of Radiologists Annual Scientific Meetings. Half the participants felt that the workshop made it more likely that they would publish. We have shown that even short workshops appear to have benefits and should be encouraged.

Australia↗
PubMed2006

Assessment of abstracts submitted to the annual scientific meeting of the Royal Australian and New Zealand College of Radiologists.

The process for selecting abstracts submitted for presentation at annual scientific meetings should ensure both the quality of these meetings and fairness to prospective presenters. The aim of the present study was to review the assessment of radiation oncology abstracts submitted for oral presentation to the 2004 Royal Australian and New Zealand College of Radiologists annual scientific meeting. Selection criteria were developed that were primarily focused on the subjective aspects of abstract quality. All research abstracts were reviewed blindly by five individual reviewers (four radiation oncologists and a statistician), scoring each abstract in five categories. The scores of three reviewers were used to select the top 30 general and top eight trainee entries. For comparison, cluster analysis using the scores of all five reviewers was used to group papers into two ranks. There was a strong correlation in total scores for each paper, between all reviewers. Similarly, the study design subscale was strongly correlated between all reviewers. Abstracts belonging to the first-rank cluster were generally selected. Most trainee entries would have been successful in being accepted into the general programme. The selection process described appears feasible and fair and may improve the quality of meetings.

Abstracting and Indexing↗
PubMed2003

A prospective trial of short-fractionation radiotherapy for the palliation of liver metastases.

The purpose of this study was to prospectively examine the effectiveness and tolerability of a simple radiotherapy technique for the palliation of symptomatic liver metastases. Twenty-eight patients with symptomatic liver metastases were enrolled from seven centres, and received targeted (partial or whole) liver irradiation consisting of 10 Gy in two fractions over 2 days. Symptoms at baseline were hepatic pain (27 patients), abdominal distension (19), night sweats (12), nausea (18) and vomiting (eight). Twenty-two patients (76%) had failed previous treatment with chemotherapy, hormonal therapy and/or high-dose steroids. Symptoms and potential toxicities were prospectively assessed at the time of treatment, then 2, 6 and 10 weeks later. Individual symptom response rates were 53-66% at 2 weeks. Partial or complete global symptomatic responses were noted in 15 patients (54%) overall. The treatment was well tolerated with two patients (7%) experiencing grade 3 toxicity (one vomiting and one diarrhoea); however, four patients reported temporary worsening of pain shortly after treatment. This simple and well-tolerated treatment achieves useful palliation.

Adult↗
PubMed2001

Prognostic value of TP53 gene mutation in adjuvant treated breast cancer patients.

We investigated the prognostic significance of mutation to the TP53 tumor suppressor gene in a series of 908 breast cancer patients treated with or without adjuvant therapies. The frequency of TP53 mutation detected by single strand conformation polymorphism (SSCP) was 19.4% (176/908) in the overall tumor series. In multivariate analysis, TP53 mutation was independently associated with worse survival in the overall (HR = 2.1, 95% CI [1.5-3.1], P<0.0001), non-adjuvant treated (HR=2.2, 95% CI [1.2-4.2], P=0.017) and adjuvant treated (HR= 2.0, 95% CI [1.3-3.1], P = 0.0009) patients.

Adult↗
PubMed2000

Small cell carcinoma of the vagina.

A case of localized small cell neuroendocrine carcinoma of the vagina is reported. The patient was treated with concurrent chemoradiation with significant toxicity but obtained a complete response. Thirteen months after therapy the patient developed distant metastasis and died shortly thereafter. Review of the literature found that patients treated with local therapy alone had a shorter survival and died of systemic disease. As with small cell neuroendocrine carcinomas arising from other sites, systemic relapse remains an important issue that warrants combination therapies, although in pelvic sites this may be associated with an increase in side-effects.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1999

Is there more than one late radiation proctitis syndrome?

PURPOSE: To investigate the significance of the various late rectal symptoms that appear after radical prostatic irradiation. PATIENTS AND METHODS: Patients with localised prostate cancer treated between 1987 and 1994 at the Mater Hospital, Newcastle with radical megavoltage irradiation were recalled for examination and to complete a detailed questionnaire concerning late radiation-induced symptoms and their effects on normal daily life. The influence of patient age treatment related variables and acute proctitis symptoms occurring during therapy or the late symptoms recorded were assessed and the relationship between late symptoms and late EORTC/RTOG score and impact on normal daily life were studied. RESULTS: The presence of symptoms of acute proctitis was the only factor to predict any of three late symptoms (urgency, frequency and diarrhoea) and late EORTC/RTOG score in this series (odds ratios: 1.7-2.57, P-values: 0.009-0.0007). Cluster and discriminant function analyses revealed the presence of five subgroups of patients with varying permutations of different late rectal symptoms, including one group with minimal symptoms (P < 0.0001). While bleeding and rectal discharge were the major contributors to late EORTC/RTOG score (P < 0.0001 and 0.04), faecal urgency and bleeding were the most important factors to impact on normal daily life (P < 0.0001 and P < 0.0003). A relatively low concordance was found between late EORTC/RTOG score and the patients' self assessment on the effect of their symptoms on their normal daily lives. Some late symptoms, including bleeding and rectal discharge become less prevalent after 3 years of follow-up with a resulting improvement in EORTC/RTOG score. CONCLUSIONS: There may be more than one late (chronic) proctitis syndrome which may be linked in greater or lesser degrees to acute proctitis symptoms occurring during therapy. Urgency is a common late symptom which often has an important impact on normal daily life and deserves recognition in late normal tissue scoring systems. Assessment of the incidence of bleeding as a measure of late rectal morbidity following prostate irradiation may underestimate the impact of these chronic effects. Confirmatory studies are necessary.

Aged↗