In vitro effects of inhalational anesthetics on viscosity of human blood.
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Anesthesia, Inhalation↗
Biomedical subjects
S C Alexander
Publications and source records attributed to S C Alexander.
Xenon inhalation as an adjunct to computerized tomography of the brain: preliminary study.
The purpose of this study is to determine whether computerized tomography can distinguish between brain tissue and brain tissue containing dissolved xenon at physiologic concentrations. Xenon is an inert gas of high atomic number (54), and is highly soluble in tissue, particularly in fat. Its presence in the brain after inhalation is manifested by well known anesthetic effects. Phantom studies using xenon in equilibrium at atomospheric pressure with water, corn oil, and milk samples of varying known fat content, demonstrate that xenon is detectable in all cases with a steep linear increase in change of attenuation factor (EMI number) with increasing fat content. In the rhesus monkey xenon is readily detectable at 20% inhaled gas concentration, with linear detectable at 20% inhaled gas concentration, with linear increase of attenuation factor with increasing concentration. The possible application of our findings to the study of brain pathophysiology is discussed. Since xenon is a potent although safe anesthestic, caution in clinical application is advised.
Animals↗
Xenon and krypton as radiographic inhalation contrast media with computerized tomography: preliminary note.
Computerized tomography (CT) scans of samples of the inert gases xenon and krypton inside a Lucite phantom, show these gases to be potentially useful inhalation contrast media with CT scanning of the chest.
Contrast Media↗
Cerebral apoplexy (stroke) treated with or without prolonged artificial hyperventilation. 1. Cerebral circulation, clinical course, and cause of death.
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Acid-Base Equilibrium↗
Halothane effects on conductivity of the AV node and His-Purkinje system in the dog.
His-bundle electrocardiography was used to evaluate the effect of halothane on AV nodal and His-Purkinje system conduction times in the spontaneously beating dog heart. During artrial pacing at basic heart rates of 120 or 200 beats per minute (bpm), an extrastimulus (cycle length longer or shorter than that of the basic rate) was delivered to test the effect of halothane on several parameters of AV nodal conductivity. Included were the functional refractory period, basal conduction time, and fatigue effect (prolongation of basal conduction time as heart rate was increased from 120 to 200 bpm). Increasing MAC level of halothane (1.25 to 2.75 MAC) prolonged both AV node and His-Purkinje conduction times, yet had little effect on the parameters of nodal conductivity tested for. These effects of halothane could be potentially dangerous in the clinical setting for patients with defective AV conduction. In addition, changes in conduction may be in part responsible for arrhythmias seen during halothane anesthesia.
Anesthesia↗