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Biomedical subjects

S C Ballon

Publications and source records attributed to S C Ballon.

At least 55 records · Page 3Linked to original sources
PubMed1979

Pretreatment lymphangiography and operative evaluation in carcinoma of the cervix.

Ninety-five patients with cervical carcinoma who were not candidates for definitive operation underwent initial lymphatic and 24-hour nodal phase lymphangiography and lymphadenectomy prior to radiation therapy. Operation by a transperitoneal or extraperitoneal approach consisted of bilateral pelvic and periaortic lymphadenectomy, exploratory laparotomy, and intraperitoneal biopsies as indicated by the findings. Radiation therapy was modified to include proved sites of metastases. Intestinal injuries followed transperitoneal operation and radiation therapy but were uncommon in patients in whom exploration was done by the extraperitoneal route. Eighteen patients (19%) had unsuspected metastases to common iliac or periaortic lymph nodes identified at operation. The characteristics of the primary tumor and the interpretation of the lymphangiogram provided an inaccurate basis on which to modify treatment. As further studies confirm the risk of disseminated disease in those patients with metastases to common iliac and the periaortic lymph nodes, future treatment plans might incorporate adjuvant chemotherapy or immunotherapy in addition to extended-field irradiation.

Evaluation Studies as Topic↗
PubMed1979

Reticuloendothelial neoplasia of the female genital tract.

Twelve patients thought to have gynecologic tumors subsequently were found to have lymphoma or leukemia. Eleven tumors involved the genital organs; one involved the retroperitoneal pelvic lymph nodes. A lymphoma originated in the genital tract in 7 patients, and secondary involvement occurred in 2 patients. One patient with a previously treated lymphoma and 1 with leukemia in remission developed ovarian tumors as the first sign of relapse. The difficulty in diagnosis, need for appropriate treatment, and prognostic importance of the genital organs affected are discussed.

Adolescent↗
PubMed1979

Topical 5-fluorouracil in the treatment of intraepithelial neoplasia of the vagina.

Twelve patients with vaginal intraepithelial neoplasia received topical therapy with 5% 5-fluorouracil cream. Six patients had carcinoma in situ, 5 had moderate dysplasia, and 1 had mild dysplasia. Five patients responded to 1 treatment course. Six patients required 2, and 1 patient required 3 courses of therapy to respond. Three patients developed recurrent vaginal intraepithelial neoplasia 11-16 months after therapy and were retreated with topical 5-fluorouracil. Vaginal irritation occurred in all patients but was limited to the duration of the treatment course.

Administration, Topical↗
PubMed1979

Primary adenocarcinoma of the vagina.

The characteristics and treatment of eight patients with primary adenocarcinoma of the vagina were reviewed. Cytologic smears of the vagina aided in the diagnosis of adenocarcinoma but, less often, detected vaginal adenosis. Good correlation existed between the degree of differentiation of the primary tumor and the tendency toward lymphatic spread. The clinical stage, size of the primary lesion, presence and duration of symptoms and lymphangiographic findings were not helpful in this regard. Pretreatment lymphadenectomy as a basis for operative staging demonstrated the critical importance of the status of the lymph nodes in the planning of therapy and determination of prognosis. Vaginal reconstruction and ovarian preservation facilitated rehabilitation.

Adenocarcinoma↗
PubMed1978

Treatment of recurrent Paget's disease of the vulva with topical bleomycin.

Seven patients with recurrent Paget's disease of the vulva underwent treatment with topical bleomycin (NSC 125066-Blenoxane, Bristol Laboratories) ointment. None had an associated invasive carcinoma. Four patients experienced a complete, objective response to this therapy, and one of these has responded completely to treatment of a subsequent recurrence. In two patients the response could not be evaluated. All patients experienced pain in the treated area; one, developed systemic toxicity to bleomycin requiring cessation of therapy. Topical bleomycin appears to benefit selected patients with recurrent Paget's disease of the vulva.

Administration, Topical↗
PubMed1978

Myeloblastoma (granulocytic sarcoma) of the ovary.

Myeloblastic neoplasms occur in patients with leukemia. In women, the ovary is a common site. The cells of the tumor are identical histochemically to those in the peripheral blood. The Giemsa stain, PAS stain, and Leder stain assist in the diagnosis. The tumors are responsive to radiation therapy, chemotherapy, and operative removal, but tend to be associated with decreased survival. This report describes a case of myeloblastoma of the ovary in an 18-year-old woman. The clinical and pathologic features of these tumors are described. The literature is reviewed briefly.

Adolescent↗
PubMed1978

Continent vesicostomy. Application in a patient.

Continent vesicostomy, as performed in the laboratory animal, allows the severely dysfunctional bladder to be emptied at predetermined intervals by transabdominal catheterization. The formation of a continent vesicostomy in a patient with markedly impaired bladder function secondary to an extended pelvic operation for the treatment of cancer is described. This technique provides a possible alternative to the construction of a urinary conduit in patients disabled from the treatment of a pelvic malignancy.

Adult↗