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Biomedical subjects

S C Goldberg

Publications and source records attributed to S C Goldberg.

At least 19 recordsLinked to original sources
PubMed2001

What happened to long-term care in the health reform debate of 1993-1994? Lessons for the future.

During 1993 and 1994, the United States debated but did not enact major health care reform. Although the reform efforts focused on providing health coverage for the uninsured and controlling acute care costs, many proposals included substantial long-term care initiatives. President Clinton proposed creating a large home-care program for severely disabled people of all ages and all income groups, among several other initiatives. By stressing non-means-tested public programs, the president's plan was a major departure from the Medicaid-dominated financing system for long-term care. In designing the long-term care component, the Clinton administration addressed many of the basic policy choices that must be decided in all reform efforts, including whether initiatives should be limited to older people or cover people of any age, how to balance institutional and noninstitutional care, whether to rely on government programs or on the private sector, and how to control costs. Analyzing the political and intellectual history of long-term care during the health reform debate provides lessons for future reform.

Aged↗
PubMed1994

Sustained attention and positive formal thought disorder in schizophrenia.

Deficits in sustained attention and formal thought disorder (FTD) are two characteristics of schizophrenia that might be expressions of a common pathology. This study examined whether a measure of enduring (post-treatment, stabilized) deficits in sustained attention, the Continuous Performance Test (CPT) could predict FTD. In addition, a comparison was made of CPT performance between subjects with schizophrenia (n = 41) and healthy controls (n = 28). Results replicated previous findings of significantly poorer performance by individuals with schizophrenia compared to normal controls. Within the schizophrenia group, significant correlations were found between FTD and CPT measures. In order to assess predictability of FTD, a hierarchical multiple regression analysis was used. CPT errors and gender both significantly predicted FTD. The most robust prediction was of residual FTD (post-treatment, stabilized) by CPT commission errors. These results lend support to the proposition that a subsyndrome within schizophrenia exists that is characterized by deficits in sustained attention and positive formal thought disorder. Furthermore, this subsyndrome might be more common in males than females.

Adult↗
PubMed1990

Medicare DRGs and post-hospital care for the elderly: does out of the hospital mean out of luck?

This article reports findings from a multistate study of the effects of medical cost containment policy, particularly the Medicare DRG (Diagnosis Related Groups) reimbursement policy, on community-based services for the elderly. The study findings reveal that since the implementation of DRGs, more older clients in poorer states of health are seeking posthospital care services. Greater client demand and illness acuity is leading to increases in service refusals to vulnerable clients and the creation of agency waiting lists. The majority of agency directors attribute the declining health status of clients to DRG reimbursement.

Aftercare↗
PubMed1989

Amphetamine challenge test, response to treatment, and lateral ventricle size in schizophrenia.

The hypothesis of two independent pathologies in schizophrenia proposed by Crow (1980) were tested. Two dimensions of the dopamine variable, namely, the behavioral response during the Amphetamine Challenge Test (ACT) and the response to neuroleptic treatment, were studied in a cohort of 19 subjects with a research diagnosis of schizophrenia (n = 18) or schizoaffective disorder (n = 1) in an acute inpatient setting. The size of the lateral ventricle was assessed by mesauring the ventricle-brain ratio (VBR) on the computerized tomographic brain scan. Patients who had greater symptom reduction with the neuroleptic treatment worsened more in their positive psychotic symptoms during the ACT. Those with larger VBRs showed less treatment responsiveness and no worsening during the ACT. The findings are supportive of Crow's hypothesis. The ACT has the potential to be an index of both Type I and Type II pathologies.

Adult↗
PubMed1989

Prediction of change in borderline personality disorder.

Prediction of change in borderlines is an important effort because it may illuminate the character of this tentatively defined, complex disorder. In future years the disorder will be defined differently in light of its network of relationships with other variables. Presently, the strongest predictors of change in borderlines are receipt of neuroleptics and presence of target symptoms that are affected by these drugs. Other drugs and other treatments may also be found to have a selectively differential effect in which case receipt of these drugs will also predict change but perhaps on other target symptoms. Preliminary evidence implicates monoamine oxidase inhibitors (MAOIs), lithium, and carbamazepine. Response to thiothixene has been found to be related to the patient's Minnesota Multiphasic Personality Inventory (MMPI) profile prior to treatment. Biological predictor variables studied in other disorders have been found to be abnormal in borderlines, but how these variables might relate to change has not been studied. The program of research that is necessary includes other drug treatments, nonphysiological treatments, family history, and personality variables.

Antipsychotic Agents↗
PubMed1988

Borderline personality disorder: replication of MMPI profiles.

The purpose of this study was to determine whether a particular MMPI profile is associated with borderline personality disorder (BPD). Forty-seven symptomatic volunteers who satisfied DSM-III criteria for borderline and/or schizotypal personality disorder were given the full MMPI. Concordance of MMPI profile for BDP confirmed the findings of four previous studies. Elevations were noted on F, D, PD, PA, PT, and SC. A subject's profile with this pattern is interpreted from item content as generally neurotic, dysthymic, socially withdrawn, suspicious, apathetic toward the future, affectively erratic, unable to anticipate the consequences of his or her own behavior, and unable to judge the social desirability of his or her own behavior. Correlations of the foregoing scales with a total BPD score ranged from .44 to .77, with a multiple R of .80 and a cross validity of .77. The accuracy of predicting actual BPD and non-BPD cases was 89%. Accordingly, the MMPI could be used as a coarse screen for BPD casefinding in that patients with the MMPI profiles above should be selected for more thorough diagnostic workup. In the future, the MMPI might be linked to other variables, such as drug response, to understand further the pathophysiology of BPD.

Adolescent↗
PubMed1988

Erratic eye tracking in schizophrenic patients as revealed by high-resolution techniques.

Using high-resolution infrared oculography with digital recording and analysis techniques, we tested several types of eye movements in 19 schizophrenic patients and 11 normal controls. Abnormal slow pursuit eye movements, seen in about half of the patients, were characterized by erratic inaccuracies in position, velocity, and phase. Tracking errors were quantitatively assessed by their root mean square (RMS) error. Position RMS errors fell into two clearly separated groups, with 10 of 19 patients clustering about the normal controls and the remaining 9 having much higher errors than normal. Although several of these poor trackers had an excess of saccades or low pursuit gain, these abnormalities were not primarily responsible for the large erratic tracking errors. Saccades in response to unpredictable target jumps had normal latencies (reaction times) and velocities, but were more hypometric and variable in accuracy than those of controls. These saccadic abnormalities did not correlate with the patients' position RMS errors during slow pursuit.

Attention↗
PubMed1988

Who benefits from tricyclic antidepressants: a survey.

To determine what patients are likely to benefit from treatment with a tricyclic antidepressant, the authors surveyed American researchers, teachers of psychiatry, general psychiatric practitioners, and foreign researchers. Areas of agreement were appreciable and can serve as an index of accepted community practice and as guidelines for teaching. Responses indicated that patients most likely to benefit from a tricyclic antidepressant are those with primary depression; early morning awakening; motor retardation; loss of appetite; weight loss; prior positive response to a tricyclic antidepressant; loss of interest in work or hobbies; sad, blue, or depressed feelings; improved mood in evening; and loss of interest in sex. Amitriptyline was preferred for agitated depressions, and imipramine was preferred for retarded depressions.

Amitriptyline↗
PubMed1986

Borderline and schizotypal personality disorders treated with low-dose thiothixene vs placebo.

Fifty outpatients with borderline and/or schizotypal personality disorder were randomly allocated to thiothixene (Navane) or placebo treatment that was continued for 12 weeks. The mean daily dosage of thiothixene hydrochloride in the final week of the study was 8.7 mg, a lower dosage than is used in outpatient schizophrenics. Significant drug-placebo differences were found, regardless of diagnosis, on "illusions," "ideas of reference," "psychoticism," "obsessive-compulsive symptoms," and "phobic anxiety," but not on "depression." Thiothixene seems to have more than an antipsychotic effect. Since response to treatment studies are a means for reformulating diagnostic concepts, we suggest a subdiagnosis defined by those symptoms that are drug-responsive, some of which are not included in current diagnostic criteria. Patients with borderline and schizotypal disorder without the foregoing symptoms probably would not profit from thiothixene and might needlessly be placed at risk for adverse drug effects.

Administration, Oral↗
PubMed1986

Diagnoses of the relatives of schizotypal outpatients.

Relatives of 22 schizotypal probands were evaluated for lifetime psychiatric diagnoses. Forty-four (N = 44) of the 97 available relatives were interviewed directly using the Diagnostic Interview Schedule. The rates of psychiatric diagnoses were compared with those of sixty-six (N = 66) of 140 relatives of 30 depressed patients. Family history of mental illness was ascertained by the informant method on the remainder of relatives of both proband groups. The rate of depression found in the relatives of schizotypal patients was 52% in those directly interviewed and 25.7% when informants' reports on unavailable relatives are pooled with direct interview data. These rates were not significantly higher than those found for the relatives of depressed probands (34.8% by direct interview and 21% including reports from informants). The high rates of depression in the relatives of schizotypal probands may indicate that schizotypal personality is associated with affective disorder and not only with schizophrenia. However, the high rates may be due to the presence of depressive character traits in relatives, which inflate the rates of dysthymic disorder and other chronic depressive disorders in the relatives of borderline patients.

Adult↗
PubMed1986

A survey of psychiatrists' practices related to the use of tricyclic antidepressants.

Four groups of psychiatrists were surveyed about their clinical practices in relation to the use of tricyclic antidepressants to determine if there is any unanimity about procedures. The four groups were U.S. experts in the pharmacotherapy of depression, faculty who taught the pharmacotherapy of depression in accredited departments of psychiatry, general psychiatrists in Virginia who treated depressions with drugs, and non-U.S. experts. The authors report on practices related to dosage buildup, side effects, concurrent medical conditions, blood level information, and maintenance on tricyclics. They found moderate to high consensus on most issues; exceptions were treatment of a patient with chronic hypertension and maintenance dosage and duration.

Ambulatory Care↗
PubMed1985

Negative and deficit symptoms in schizophrenia do respond to neuroleptics.

Five large-scale placebo-controlled studies are cited to show that, contrary to the contention of Johnstone et al. (1976) and Crow (1980), negative and/or deficit symptoms in schizophrenia do indeed respond to neuroleptic treatment. Further evidence is given that it is the "organic-like" symptoms (visual and olfactory hallucinations, disorientation, and memory deficit) that do not respond to neuroleptics. This would more sensibly reformulate the hypothesis of Johnstone et al. (1976) and Crow (1980) to state that schizophrenic patients with enlarged ventricles tend to show symptoms of organicity and tend not to respond to neuroleptics.

Antipsychotic Agents↗