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S C Sahu

Publications and source records attributed to S C Sahu.

39 records · Page 3Linked to original sources
PubMedDate not supplied

Effects of intermittent exposures of aflatoxin B(1) on hepatic and testicular glutathione S-transferase in rats.

Glutathione S-transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B(1) (AFB(1)). This study evaluated the effects of intermittent exposures to AFB(1) on hepatic and testicular GST in rats. Male Fischer 344 rats were fed diets containing AFB(1) (0, 0.01, 0.04, 0.4 and 1.6 ppm) intermittently at 4-week intervals up to 20 weeks. The control animals were fed an AFB(1)-free NIH-31 diet. Rats consuming diets with 0.01 ppm AFB(1) did not show the induction of hepatic or testicular GST activity. Intermittent exposures to AFB(1) at concentrations of 0.04-1.6 ppm significantly increased the GST activities. The increase of the enzyme activity was proportional to the dose and length of AFB(1) exposure.

Aflatoxin B1↗
PubMedDate not supplied

Evidence for the involvement of serotoninergic system in the male-induced ovo-implantation failure (Bruce effect) in mice.

Failure of ovo-implantation in newly mated female mice induced by exposure to alien males (Bruce effect) was prevented by administration of 2-(1-piperazinyl) quinoline maleate (quipazine). Since quipazine has serotonin receptor agonistic effect resulting in the elevation of prolactin secretion, it is suggested that the increased secretion of prolactin induced by the drug prevented the Bruce effect. The results suggest the involvement of the serotoninergic system in the sequence of events that leads to the Bruce effect.

Animals↗