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Biomedical subjects

S C Sehgal

Publications and source records attributed to S C Sehgal.

14 recordsLinked to original sources
PubMed1990

Epidemiology of male urethritis in Nigeria.

One thousand and seventy-two symptomatic male cases of urethritis were investigated. Of these, 643 (60%) had gonococcal aetiology; 579 (54%) of all cases were in the 21-30-year age group while only 21 (2%) were above 50 years and 654 patients were married, 418 unmarried. Traders, civil servants and students accounted for 33.8, 29.5 and 26.7% of cases respectively. Sokoto state of Nigeria was less affected with the disease than other areas. Three hundred and eighty-six patients gave a history of previous therapy and only 183 of these yielded gonococci. Seventy-two per cent of gonococcal isolates were penicillinase producers. It appeared that the social, cultural and religious beliefs of the local population had tremendous influence on the incidence of the disease.

Adolescent↗
PubMed1990

Pattern of genito-urinary parasitic infections at the Teaching Hospital, Sokoto, Nigeria.

Urinary schistosomiasis was more frequently observed among subjects aged 10-19 years old; and the degree of exposure to the infection was found to be high among the males. Comparative analysis of T. vaginalis infection among the females revealed a ten-fold increase in the detection rate for the flagellate in the urine samples collected from the Special Treatment Clinic than those from Out-patient department. The age-specific morbidity pattern for Trichomonal vaginitis was remarkably high among females of maximum sexual activity (i.e. 20-29 years old), 6(12.24%) and 4(8.16%) of the 49 cases of Trichomonal vaginitis had mixed infections with Neisseria gonorrhoae and Candida albicans respectively. The association between detection of haematuria, proteinuria and urinary schistosomiasis was supported. Age, sex and social behaviour were identified as important determining factors on pattern of genito-urinary parasitic infections.

Adolescent↗
PubMed1979

Mycetomas in North India.

Of 60 clinically suspected cases of mycetoma, 20 were confirmed by cultural and histopathological methods. The feet were found to be affected in 70% of the cases. The age group most affected by the disease was 20-40 years. Men were involved in 18 while females were affected in 2 cases only. Actinomycetomas (70%) were found more often than eumycetomas (30%). Nocardia species were identified in 35% of cases and Madurella mycetomi in 25%. There were four cases (20%) where the etiological agents could not be identified; these were suspected to be due to Actinomadura madurae. A. pelletieri, A. madurae, an unidentified anaerobic actinomyces, and Phialophora jeanselmei, were identified in one case each.

Actinomycetales↗
PubMed1979

Canidida infection of the upper gastrointestinal tract superadded upon chemical injury with acids.

Two male patients, who presented with Candida albicans infection of the upper gastrointestinal tract, superadded over local mucosal injury due to corrosive chemical agents and chronic alcoholism have been described. Such an association of prior local injury with this type of fungal infection has not been hitherto documented. One of these patients had a gastric antral stricture due to ingestion of concentrated sulfuric acid and Candida esophagitis, whereas the other had severe erosive gastritis and Candida gastritis following ingestion of thiocyanates.

Adult↗
PubMed1978

Antibodies to phospholipids in experimental nocardiosis.

Live Nocardia asteroides injected intraperitoneally into guinea pigs produced antibodies to phospholipids of Nocardia whereas antibodies were not detected in animals injected with heat-killed N. asteroides. The antibody titer was found to be related with the degree of infection; a significant decrease was noted after sulfadiazine treatment suggesting that antibodies were produced in response to an increasing bacterial load that occurred as the infection progressed.

Animals↗
PubMedDate not supplied

The role and prevalence of Gardnerella vaginalis in anaerobic vaginosis.

310 cases of anaerobic vaginosis and 80 asymptomatic females were studied for the detection of various organisms from their genital specimens. The main complaint of the symptomatic cases was vaginal discharge. Neisseria gonorrhoeae, Candida albicans, Trichomonas vaginalis. Bacteroides species, anaerobic cocci and Gardnerella vaginalis were detected. The frequency of detection of all except C. albicans was less in pregnant than non-pregnant women. However, the prevalence of anaerobes and G. vaginalis was significantly lower in both the symptomatic and asymptomatic pregnant than the non-pregnant women. G. vaginalis showed mutualism with anaerobic bacteria and was not isolated as a pure culture in any of the cases. It appears that G. vaginalis, like anaerobes, has variable prevalence rates and is under the influence of local physiological and hormonal factors. This organism does not appear to have a primary pathogenic role, but assumes a secondary role in association with non-sporing anaerobes in the pathogenesis of anaerobic vaginosis.

Female↗
PubMedDate not supplied

In-vitro activity of lomefloxacin (SC-47111) and other quinolones.

The in vitro activity of lomefloxacin, a new difluorinated quinolone, was compared to that of ciprofloxacin, ofloxacin, norfloxacin and other relevant antibacterial agents. Lomefloxacin and norfloxacin shared similar activity, whereas ofloxacin and in particular ciprofloxacin showed superior activity. Most gram-negative aerobes were susceptible to all four quinolones, 90% of isolates were inhibited by 1 mg/l. The gram-positive organisms were generally less susceptible, although 90% of Staphylococcus aureus isolates were inhibited by 0.5 mg/l of ciprofloxacin and ofloxacin; values for lomefloxacin and norfloxacin were 1 mg/l and 2 mg/l, respectively; susceptibility was not affected by methicillin resistance. Neisseria gonorrhoeae and Haemophilus influenzae were highly susceptible to the quinolones, especially ciprofloxacin. Penicillin/ampicillin-resistant isolates remained susceptible to the quinolones.

4-Quinolones↗
PubMedDate not supplied

Microbial flora and its significance in pathology of sickle cell disease leg ulcers.

The microflora and its significance was investigated in 82 leg ulcers in patients with sickle cell disease. Staphylococcus aureus, Pseudomonas aeruginosa and group A streptococci were the most common isolates. The majority of ulcers which yielded these organisms showed signs of local inflammation, regional lymphadenopathy and healed slowly as compared with ulcers which did not show these organisms. Repeat culture swabs demonstrated persistence of these organisms. A topical spray containing neomycin, polymyxin B and bacitracin helped to eradicate these organisms and hastened the healing process of ulcers. Coliforms and anaerobes were also isolated but were transient in nature and of no significance in the pathology of such ulcers.

Adolescent↗