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Biomedical subjects

S C Towler

Publications and source records attributed to S C Towler.

5 recordsLinked to original sources
PubMed1990

Diarrhoea during enteral feeding in the critically ill: a comparison of feeds with and without fibre.

This randomised double-blind study examined the frequency of diarrhoea in intensive care unit patients given a fibre-containing feed, Enrich, and a fibre-free feed, Ensure. A daily 'diarrhoea score' was calculated from the frequency, volume and consistency of the stools. A score greater than 12 indicated diarrhoea, and greater than 50 severe diarrhoea. Ninety one patients met the criteria for participation: Enrich 45, Ensure 46. The groups were similar in age, sex ratio, feed volume, antibiotic usage, upper gastro-intestinal bleeding prophylaxis and plasma albumin concentrations. Diarrhoea occurred in 16 patients given Enrich and 13 given Ensure, severe diarrhoea affecting 5 and 9 respectively (NS). Forty seven of 343 (14%) Enrich feeding days and 51 of 342 (15%) Ensure feeding days were complicated by diarrhoea--severe diarrhoea: 8 and 12 feeding days (NS). We conclude soy polysaccharide (21 g/L) did not reduce diarrhoea in intensive care unit patients given enteral feeds.

Adult↗
PubMed1990

Elimination kinetics of sevoflurane and halothane from blood, brain, and adipose tissue in the rat.

Using the rat as an animal model, the elimination kinetics of sevoflurane and halothane from brain, blood, and adipose tissue were compared. Elimination of sevoflurane and halothane from blood and brain was biexponential. The rapid, alpha-elimination rates of sevoflurane from blood and brain were faster than the corresponding rates for halothane. However, the slower beta-elimination rates from brain and blood, as well as the elimination rates from adipose tissue, were similar for both volatile anesthetics. Thus, the potential for residual postoperative impairment from subanesthetic tissue concentrations of halothane and sevoflurane may be similar even though sevoflurane is initially eliminated more rapidly from blood and brain.

Adipose Tissue↗