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Biomedical subjects

S C Wood

Publications and source records attributed to S C Wood.

4 recordsLinked to original sources
PubMed1978

Regulation of intracellular pH in lungs and other tissues during hypercapnia.

Using a 14C-labeled DMO, 36Cl and 3H method, we have determined the in vivo buffering capacity of lung, kidney, heart, skeletal muscle, and extracellular fluid (ECF) of guinea pigs during hypercapnia (FICO2 = 0.15). After 1 days' exposureto 15% CO2, both the relative CO2 buffer values (delta HCO3/deltapH) and the "%pH regulation" were lung greater than kidney greater than heart greater than ECF greater than skeletal muscle. For lung tissue the intracellular pH was significantly decreased only during acute (8 h) hypercapnia and had completely returned to control values after 7 days with arterial PCO2 congruent to 122 Torr. Kidney and cardiac muscle also showed ca. 100% regulation of pH at 7 days, whereas skeletal muscle and ECF showed only 80 and 70% pH regulation, respectively. The results are discussed with respect to the important (and pH-dependent) metabolic functions of the lung and kidney.

Animals↗
PubMed1976

Temperature acclimation and oxygen-binding properties of blood and multiple haemoglobins of rainbow trout.

Acclimation of rainbow trout to 5, 15 and 22 degrees C for periods exceeding 4 months had no significant effect on the oxygen affinity of whole blood or on the concentration of ATP, which is the main organic phosphate in red cells. Slight differences were, however, found in the oxygenation properties of the haemolysates, which correlate with changes in the relative concentration of the multiple haemoglobins. The oxygen-binding properties of the main haemoglobin components account for the observed differences in the haemolysates. The possible thermoacclimatory significance of changes in haemoglobin multiplicity and co-factor concentrations is discussed.

Adaptation, Physiological↗
PubMed1975

Oxygen uptake and blood respiratory properties of the caecilian Boulengerula taitanus.

In contrast to amphibians belonging to the orders Urodela and Anura, virtually no data exist on the respiratory physiology of the more primitive Apoda. This study concerns oxygen uptake and hemoglobin function in the caecilan Boulengerula taitanus, an apodan with fossorial habits. The oxygen uptake rate resembles that of other amphibians of similar size. The blood was high O2 capacity (14 vol%) and the erythrocytes are smaller, and the red cell count is greater than in other amphibians. The oxygen affinity of whole blood is high compared to other amphibians (P50 = 28 mm Hg at 25 degrees C and pH 7.6). The oxygen equilibrium curve is sigmoid (n = 1.79) and the Bohr factor is small (deltalog P50/deltapH = - 0.21). In 'stripped' hemoglobin solutions oxygen affinity increases strongly (P50 = 3.3 mm Hg at 25 degrees C and pH 7.6) and the temperature sensitivity is high (apparent deltaH=-19.4 kcal/mole), but the ATP and pH influences are too low to account for the difference in P50 compared to whole blood. The high oxygen capacity and oxygen affinity and the low Bohr factor may have adaptive significance to this fossorial amphibian.

Adenosine Triphosphate↗