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Biomedical subjects

S Cabib

Publications and source records attributed to S Cabib.

80 records · Page 5Linked to original sources
PubMed1985

Pharmacological evidence for a protective role of the endogenous opioid system on electroshock-induced seizures in the mouse.

Acute administration of morphine produced a protective effect on electroshock (ECS)-induced seizures in mice, while naloxone and naltrexone decreased ECS seizure threshold. Chronic morphine administration in mice resulted in a decrease of ECS-induced seizure threshold evident within 24 h following the end of drug treatment. This effect disappeared 5 days after the end of chronic morphine treatment. Moreover, tolerance to the anticonvulsant effect of morphine was evident in mice chronically treated with morphine and subjected to ECS 30 min after the last injection of the drug, as well as in mice subjected to ECS 24 h after the end of chronic treatment.

Animals↗
PubMed1985

The effect of age on two kinds of aggressive behavior in inbred strains of mice.

Shock-induced aggressive behavior is absent or very weak in C57BL/6 mice at the age of 12 weeks, increases at the age of 16 weeks and reaches the highest levels at the age of 20 weeks. This age-dependent increase of aggressive responses is absent in BALB/c and DBA/2 mice at the three ages examined in our experiments. Social isolation induces a clear age-dependent increase of aggressive behavior in BALB/c and DBA/2 mice (the highest level being evident at 20 weeks of age) but not in C57BL/6 mice which are characterized by the lowest or absence of aggressive responses. These results are discussed in terms of the role of developmental and genetic factors in the expression of shock- and isolation-induced aggressive behavior in the laboratory mouse.

Age Factors↗
PubMed1985

Different effects of apomorphine on climbing behavior and locomotor activity in three strains of mice.

Apomorphine (0.1, 0.25, 0.5, 1, 3 mg/kg, SC), induces a dose-dependent reduction of locomotor activity in DBA/2(DBA) and BALB/c(BALB) mice, while it enhances locomotor activity in a biphasic way in C57BL/6(C57) mice. On the other hand, apomorphine is ineffective in modifying climbing behavior in DBA mice while it increases climbing behavior in C57 and BALB mice. The results, taken together, suggest that these are two different behaviors, possibly controlled by different dopaminergic mechanisms depending on the genetic makeup.

Animals↗
PubMed1985

A genetic analysis of stereotypy in the mouse: dopaminergic plasticity following chronic stress.

After repeated stressful experiences, DBA/2 (DBA) mice showed an increase in apomorphine-induced climbing while C57BL/6 (C57) mice showed a clear-cut decrease of this behavior. Genetic analysis involving F1 and F2 hybrids and the backcross populations (F1 X C57; F1 X DBA) indicated complete dominance of the C57 genotype and a significant genotype X environment interaction. These findings are discussed in terms of dopaminergic plasticity and of the heuristic value of this animal model in relation to disturbed behaviors triggered by stressful experiences.

Animals↗
PubMed1984

Serotonin levels and turnover in different brain areas of isolated aggressive or non-aggressive strains of mice.

After eight weeks of individual housing DBA/2 but not C57 B1/6 (C57) mice showed high levels of aggressive responses in comparison with grouped mice. Social isolation did not modify serotonin (5-HT) levels in either strain of mice, while it produced a decrease of turnover rate in amygdala, lateral hypothalamus and pons in C57 mice and in lateral hypothalamus and pons of DBA mice. When isolated mice of both C57 and DBA strains are compared, no differences in turnover rate in amygdala and pons are evident, while isolated DBA mice show significant lower turnover values in lateral hypothalamus in comparison with isolated C57 mice. A possible suggestion emerging from our results is that aggressive responses exhibited by isolated DBA mice but not by isolated C57 mice may be related to lower 5-HT turnover rate in lateral hypothalamus.

Aggression↗
PubMedDate not supplied

Effects of corticotropin releasing factor and sauvagine on social behavior of isolated mice.

Corticotropin releasing factor (CRF) and sauvagine (SVG) when injected ICV both reduced aggressive behavior and sociability while increasing defensive behavior in isolated DBA/2 mice interacting with a group-housed intruder. SVG was more effective than CRF in producing such behavioral effects. These results add further evidence to the similarity between CRF and SVG, and are discussed in terms of the involvement of these peptides in emotional reactivity in the laboratory mouse.

Aggression↗