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Biomedical subjects

S Canter

Publications and source records attributed to S Canter.

7 recordsLinked to original sources
PubMed1998

Acute intravenous administration of ondansetron and m-CPP, alone and in combination, in patients with obsessive-compulsive disorder (OCD): behavioral and biological results.

Obsessive-compulsive disorder (OCD) has been linked to abnormal function of brain serotonin (5-HT) pathways. Since ondansetron is a highly selective 5-HT3 receptor antagonist, the present study was undertaken to investigate 5-HT3 function in OCD. We administered m-CPP (0.08 mg/kg i.v.) and the potent 5-HT3 antagonist, ondansetron (0.15 mg/kg i.v.), to 11 OCD patients. All of the subjects received four separate challenges (m-CPP + placebo, m-CPP + ondansetron, ondansetron + placebo and placebo + placebo). In comparison to placebo, administration of m-CPP was associated with significant behavioral effects, particularly self-rated measures of anxiety, altered self-reality, functional deficit and OCD symptoms. Pretreatment with ondansetron did not affect any of the self-rated behavioral symptoms. After administration of m-CPP relative to placebo, significant increases in plasma cortisol and prolactin were found. These changes were not affected by ondansetron. In conclusion, our results do not support the hypotheses that 5-HT3 receptor-mediated mechanisms modulate m-CPP's behavioral and neuroendocrine effects in patients with OCD.

Adult↗
PubMed1994

Social skills.

Explore the source record for details and available documents.

Assertiveness↗
PubMed1984

Alcohol dependence and phobic anxiety states. I. A prevalence study.

Sixty alcoholics (40 males) were assessed for agoraphobia and social phobia, and over half the sample were rated as having either or both these disorders when last drinking. Twenty one subjects had mild phobias and eleven had severe phobias. The more severely phobic males were also found to be the most alcohol dependent and those with no phobias were least alcohol dependent but this effect was not found among the females. All phobic alcoholics reported that alcohol had helped them to cope in feared situations, and almost all had deliberately used it for this purpose. A small sample of out-patients referred for phobias alone were also asked about their use of alcohol. The majority had found it helpful in coping with fears, although more men than women had deliberately used it for this purpose.

Agoraphobia↗
PubMed1984

Alcohol dependence and phobic anxiety states. II. A retrospective study.

Twenty-four hospitalised problem drinkers who were currently suffering from a phobic anxiety state served as subjects for this study. Each was given a detailed retrospective interview concerned with the development over time of both their alcohol dependence and phobic problems. The test-retest and inter-rater reliabilities of the data collected were found to be high. In accordance with previous experimental work, periods of heavy drinking and dependence upon alcohol were associated with an exacerbation of agoraphobia and social phobias. Subsequent periods of abstinence were associated with substantial improvements in these phobic anxiety states. It is suggested that both learning and psychobiological processes underly these observed relationships and that the implications of this finding for treatment of both disorders should be explored.

Agoraphobia↗