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Biomedical subjects

S Caputo

Publications and source records attributed to S Caputo.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Ehler-Danlos syndrome (type V) with urethra bifida and polydactyly: an unusual combination].

Ehlers-Danlos syndrome is currently regarded as a connective tissue dysplasia. Its genetic, biochemical, histological and clinical features are described, together with a personal case in a patient who presented the fundamental symptoms, plus polydactyly and bifid urethra. This association had not been hitherto reported in the literature. The case itself is classed as Ehlers-Danlos syndrome type V.

Abnormalities, Multiple↗
PubMedDate not supplied

Blunted erythropoietin response to anemia in patients with Type 1 diabetes.

BACKGROUND: It is known that patients with renal failure have normochromic normocytic anemia due to impaired endogenous erythropoietin (EPO) synthesis. The aim of this work was to determine whether low serum erythropoietin (s-EPO) levels play a role in the pathogenesis of anemia in patients with Type 1 diabetes without overt nephropathy. METHODS: We included in the study 13 patients with Type 1 diabetes whose Hb levels were <11 g/dl. Blood cell count, s-EPO, urinary albumin excretion rate (AER), HbA(1c), glomerular filtration rate, serum iron, serum ferritin, the presence of neuropathy, retinopathy and nephropathy were determined. RESULTS: Ten out of 13 patients with anemia (77%) had a blunted EPO response to anemia. All ten patients with low EPO levels had autonomic neuropathy; five had clinical nephropathy but with serum creatinine<1.6 mg/dl. Three patients were treated with rHuEPO and showed an improvement in their anemia after treatment. CONCLUSION: The majority of patients with Type 1 diabetes who had anemia also had low EPO levels. The pathogenesis of this phenomenon is probably multifactorial. Autonomic neuropathy appears to play a role, but it is not sufficient, per se, to be the only cause. Dysautonomia might enhance the effect of renal damage.

Adult↗
PubMedDate not supplied

Decreased insulin binding to red blood cells in liver cirrhosis.

eleven male cirrhotic subjects, all with impaired glucose tolerance (IGT), were studied. Insulin binding to circulating erythrocytes was evaluated. The specific bound fraction was decreased compared to normals (5.95 +/-0.76 vs 7.08 +/- 0.84%; p less than 0.005). An negative correlation was found between fasting insulin and bound fraction (r = -0.68; p less than 0.05). We suggest that serum insulin may be chronically augmented as a consequence of liver damage. This induces a down-regulation of insulin receptors that is responsible for insulin resistance and at least in part for the impairment of glucose tolerance.

Erythrocytes↗
PubMedDate not supplied

Ketoalkalosis as a result of triple derangement of acid-base equilibrium in a diabetic patient.

A diabetic patient presented with weight loss, ketosis, and hyperventilation, thus mimicking the clinical picture of diabetic ketoacidosis. Laboratory investigations revealed alkalemia and a pattern consistent with a triple derangement of acid-base equilibrium: respiratory alkalosis, metabolic acidosis and metabolic alkalosis. High cortisol level suggested a genesis of ketosis different from diabetes mellitus. The patient died suddenly from acute gastrointestinal bleeding. Autopsy showed a carcinoma of the head of the pancreas with secondary portal hypertension and rupture of varices. Pulmonary micrometastases were demonstrated. It is suggested that stress hormones were the main cause of the 'ketoalkalotic' pattern observed.

Aged↗
PubMedDate not supplied

[Etiology and epidemiology of extrauterine pregnancy].

In the last years, ectopic pregnancy has become a frequent problem, especially in the industrialized countries. Women aged 30-40 years are mostly affected. Infact, in this ten-years period, more and more women feel the desire of pregnancy at ripe age, first of all because of their job. This study shows 136 cases of extrauterine pregnancy, observed at our hospital, I and II Institute of Obstetric and Gynecological Clinic of "Policlinico Umberto I" in Rome from January 1997 to December 1999. The object of this analysis is to determine the characteristics and ethiologic factors of this pathology.

Adolescent↗
PubMedDate not supplied

[Epilepsy and pregnancy].

Epilepsy is one of the most common pre-existing neurologic disorders encountered by the obstetrician (1) and pregnant women with epilepsy constitute 0.5% of all pregnancies (2). Pregnant women with epilepsy are at risk for a variety of complications (3). Pregnancy may influence the course of epilepsy and epilepsy and antiepileptic drug therapy may have an impact on the course of pregnancy and pregnancy outcome. This study represents a retrospective analysis of 40 pregnant patients with epilepsy.

Adult↗
PubMedDate not supplied

[Prognosis and treatment of cervix uteri carcinoma in pregnancy].

Carcinoma of the cervix is tha most common ginecologic cancer found during pregnancy. Management and treatment of this condition depend on cancer stage and estimated gestational age. Pregnancy represents an ideal time for cervical cancer screening, and all pregnant women presenting for prenatal care should be carefully examinated. The prognosis for pregnant women is similar to that for non-pregnant one. The aim of this study is to review the incidence, treatment and prognosis of this condition during pregnancy.

Female↗
PubMedDate not supplied

[Asymptomatic bacteriuria in pregnancy].

Pregnancy is a predisposing factor for urinary tract infection and pregnant women suffering from this pathology are exposed to dangerous risks which may condition maternal wellbeing and fetal prognosis. Asymptomatic bacteriuria is the common bacterial infection requiring medical treatment in pregnancy. Diagnosis and treatment of asymptomatic bacteriuria is important as approximately 20-40% of these women, if untreated during pregnancy, will develop a symptomatic urinary tract infection.

Bacteriuria↗
PubMedDate not supplied

[Bacterial vaginosis and pregnancy].

Premature rupture of membranes (PROM) occurs in approximately 5-10% of all pregnancies and is implicated in approximately one third of preterm births. PROM is associated with increased risks of perinatal as well as maternal morbidity and mortality at every gestational age. Much information suggest that the presence of bacterial vaginosis may be implicated in the occurrence of PROM and subsequent preterm delivery in significant numbers of pregnant women. We will briefly review clinical and pathophysiologic information linking bacterial vaginosis and PROM.

Female↗
PubMedDate not supplied

[Catamenial epilepsy].

Many women with epilepsy report changes in seizures frequency in relationship to their menstrual cycle. Evidence from animal experiments and studies in humans have demonstrated an ovarian steroid hormone effect on neuronal excitability. The entity of the problem and its treatment have yet to be systematically evaluated. Is important to clarify the etiology and pathogenesis of catamenial fluctuations in seizure frequency and to outline optimal management strategies.

Abnormalities, Drug-Induced↗