Biomedical subjects
Publications and source records attributed to S Casadio.
The synthesis of 2-[(7-chloro-4-quinolyl)-amino] benzoic acid 3-pyridine carboxamide-N-ethyl ester (nicafenine) was carried out by a new method using isatoic anhydride. The IR, NMR, MS and UV spectrophotometric studies are described, together with the characteristics of this compound.
Explore the source record for details and available documents.
Systemic effects resulting from dextran induced general inflammation in rats were studied. The phlogogenic agent was i.p. or i.v. injected. Dextran led to an increase in hematocrit values and erythrocyte counts. A decrease in blood total proteins, fibrinogen and sedimentation rate was observed, too. ADP mediated platelet aggregation was also decreased.
Repercussions on blood of inflammation induced by carrageenin injection in the four paws of rats were studied. Two stages were observed. 4 h after carrageenin injection, a high fall in leucocyte count and a small decrease in blood total proteins and blood fibrinogen were registered. ADP mediated platelet aggregation and sedimentation rate were not modified. 24 h after carrageenin injection, sedimentation rate and blood fibrinogen were increased; some platelet hyperaggregation with ADP was also observed.
Explore the source record for details and available documents.