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Biomedical subjects

S Cengiz

Publications and source records attributed to S Cengiz.

11 recordsLinked to original sources
PubMed2000

Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats.

In this study, age-related changes of GM1, GD1a, GT1b fractions of gangliosides were investigated in whole brain of male Wistar albino rats. Insignificant increases were detected in GM1 values from the third to the 24th month, whereas GD1a and GT1b concentrations of ganglioside in 24-month-old rats decreased significantly as compared to 6-month-old rats. Although there were no significant differences in the GD1a/GT1b ratio of any groups, GM1/GD1a and GM1/GT1b ratios were significantly increased as compared to 6-month-old rats. The increase in the ratios of gangliosides are not due to an increase of GM1 fractions; they result from a decrease of GD1a and GT1b fractions of gangliosides. In conclusion, the concentration of ganglioside decreased with ageing.

Age Factors↗
PubMed2000

Accuracy of frozen section diagnosis in borderline ovarian malignancy.

This study was conducted to determine the accuracy of frozen section diagnosis in borderline ovarian tumors. Thirty-three patients were evaluated on the basis of frozen sections between February 1992 and December 1997. Frozen section diagnosis and final diagnosis were divided into three categories: for frozen section diagnosis: 1 = benign, 2 = borderline, 3 = 'at least' borderline, and for final diagnosis: 1 = benign, 2 = borderline, 3 = cancer. Three patients with a benign diagnosis according to their frozen sections were reclassified as borderline in the final diagnosis and all of them were of the mucinous type. The frozen section diagnosis of tumors of borderline malignancy was inaccurate in 3 of 23 patients. Four of 7 patients with at least borderline according to their frozen section diagnosis had invasive cancer at the final diagnosis. The correlation between frozen section diagnosis and final pathological examination was 72.7% (24/33). We found 9% (2/22) inaccurate results in the serous type and 36.6% (4/11) in the mucinous type. The sensitivity and specificity of frozen section diagnosis were found to be 86.95 and 57.14%, respectively. We concluded that frozen section evaluation in identifying a borderline ovarian malignancy is accurate enough to exclude the presence of a benign pathology.

Adenocarcinoma, Mucinous↗
PubMed1999

N-acetyl-beta-glucosaminidase and beta-galactosidase activity in children receiving antiepileptic drugs.

To evaluate renal tubular function in children receiving antiepileptic drugs the urinary activity of two lysosomal enzymes, N-acetyl-beta-glucosaminidase and beta-galactosidase, were measured. The enzyme levels were determined before the administration of antiepileptic drugs and 8 months after. Fourteen epileptic children received valproate, and 17 received carbamazepine. The urinary activity of these enzymes in 25 healthy control patients also was examined. Increased N-acetyl-beta-glucosaminidase activity was found in 50% of patients taking valproate and in 17.6% of patients taking carbamazepine. Increased beta-galactosidase activity was found in 28.5% of patients taking valproate and 11.7% of patients taking carbamazepine compared with the results before treatment. On the basis of these results, it is suggested that patients taking antiepileptic drugs, especially valproate, may demonstrate minor signs of tubular dysfunction. In those patients who use these drugs at increased dosage levels or for long periods, the possibility of tubular dysfunction may be increased, and these dysfunctions may manifest in clinical symptoms.

Acetylglucosaminidase↗
PubMed1999

Age-dependent changes in liver ganglioside levels.

Gangliosides, sialic acid-containing glycosphingolipids, are found in the outer layer of the plasma membrane of all vertebrate tissue cells; the highest concentration is in the central nervous system. In recent years, there has been research on the distribution and quantity of gangliosides in extra-neuronal tissues, such as liver, kidney and intestine. Since liver is the main source of gangliosides that are carried by lipoproteins in the blood, we examined the effect of development and aging on gangliosides in liver tissue. The relationship was investigated between GM1, GD3, GD1a, GD1b, GT1b ganglioside fractions and the aging process in liver tissue of Wistar-Albino rats aged 3, 6, 12 and 24 months. HPLC analysis of liver gangliosides showed the following results: Compared to 3 month-old rats, the GM1 fraction was decreased by 50% in 6 month-old rats, increased in 12 month-old rats and decreased in 24 month-old rats. The GD3 and GD1b fractions increased until 12 months of age and were decreased significantly (p < 0.01) in 24 month-old rats. The GD1a ganglioside fraction was significantly increased in 6 and 24 month-old rats (p < 0.01). We concluded that the increment of the polar fractions, such as GD3 and GD1b, and the variations of the other fractions in the plasma membrane of the hydrophilic liver tissue during the first 12 months were important parameters.

Aging↗
PubMed1994

Peripheral and central conduction in n-hexane polyneuropathy.

Electrophysiological findings of 27 males with industrial n-hexane polyneuropathy (HPNP) are presented. The results of needle electromyography and nerve conduction studies were compatible with primarily axonal polyneuropathy with secondary segmental demyelination. Motor conduction velocities were the slowest in distal regions of the nerves. In the proximal nerve segments, which were partly tested by magnetic stimulation of the nerve roots, this slowing was much less pronounced. The reduction in mean motor conduction velocities in the forearm segments of ulnar nerves was more than 30% in comparison to the control group means. This reduction was only 10% in the neck-axilla segments. We think that this finding is a reflection of the distal axonopathy process. Central motor conduction times calculated by transcranial magnetic stimulation and spinal nerve root stimulation were found to be prolonged in HPNP patients, indicating that descending motor pathways are affected in human HPNP.

Adolescent↗
PubMed1994

Effect of mercury from dental amalgams on mercury concentration in urine.

A study was conducted to determine the mercury concentration in urine after placement of dental amalgam restorations. The 24-h urine mercury levels in 10 children with a mean age of 8 years were determined before the amalgam restorations had been placed, and after placement. The urinary mercury content was measured by the cold vapor atomic fluorescence method. Mercury levels in the urine samples before placement of the amalgam restorations were below the detection limit, and the values obtained after placement, although detectable, were far below the limits stipulated by the World Health Organization. Under the conditions of this study, it is considered that the mercury levels released from dental amalgams are not high enough to cause any systemic toxic effect.

Body Burden↗
PubMed1993

Vigabatrin as an anticonvulsant against pentylenetetrazol seizures.

The anticonvulsant effects of gamma vinyl GABA (GVG) were investigated against pentylenetetrazol (PTZ) seizures, while sodium valproate (VP) was used as positive control. At 1000 and 1500 mg kg-1 GVG was found to decrease seizure intensity either in 4 or 24 h, as effectively as VP. At 2000 mg kg-1 GVG was found to be almost ineffective. At both doses and both time spans of drug action, seizure latency was prolonged, compared to controls and VP group.

Aminocaproates↗
PubMed1993

Primary ovarian leiomyoma. A case report.

A 32-year-old woman was admitted for termination of her 6-week pregnancy at her request. However, pelvic examination followed by transvaginal ultrasonography (TVU) revealed an adnexal mass complicating pregnancy and requiring surgical intervention that was carried out after termination of pregnancy. At laparotomy, left salpingo-oophorectomy was performed and histologic examination revealed a leiomyoma arising primarily in the ovary.

Adult↗
PubMedDate not supplied

Comparison of topical glyceryl trinitrate ointment and oral nifedipine in the treatment of chronic anal fissure.

This study was designed to compare the effect of topical glyceryl trinitrate (GTN) and oral nifedipine treatments on maximal anal resting pressure (MARP) and subsequently to assess their effectiveness in healing of chronic anal fissure (CAF). Patients were allocated randomly to receive either oral nifedipine retard (10 patients) 20 mg twice daily or instructed to apply glyceryl trinitrate (0.2 percent) ointment (10 patients) into the lower half of the anal canal twice daily. They were reviewed and assessed at the first visit and every fortnight for measurement of MARP, pain scores, blood pressure, pulse rate, healing of the fissure and adverse effects. Treatment were continued until healing had occurred or for up to 8 weeks. MARP values before and after application of the GTN ointment was 113.2 cm H2O and 72.5 cm H2O respectively (P < 0.001). Nifedipine caused a reduction in mean MARP from 105.2 to 74.0 cm H2O (P < 0.001). Linear analogue pain scores were significantly reduced after 2 weeks treatment with GTN and nifedipine (P < 0.001) and continued throughout the treatment period. At the end of the study; 7 of the 10 patients in the GTN group were deemed to be healed (5) or improved (2), compared with 6 of the 10 patients in the nifedipine group (5 healed, 1 improved). Headaches occurred in 3 patients in the GTN group, compared with one patient in the nifedipine group. There was no significant difference between GTN and nifedipine in terms of reduction in MARP and pain score, healing of the fissure and incidence of early recurrence and side effects of treatments. We conclude that GTN ointment and oral nifedipine are equally effective in the treatment of chronic anal fissure.

Administration, Oral↗
PubMedDate not supplied

The alteration on serum thyroid hormones and iodine levels when the 10% povidone iodine solution was topically performed on ano-rectal mucosa.

In this experiment, the 10% povidone-iodine (PI) solution was topically administered on ano-rectal mucosa by enema and its effects on thyroid hormones and iodine levels in serum were examined in rabbits. The solution was given in a volume of 20 ml daily for three days. Blood samples were drawn at 1st, 4th and 7th days after the first enema. The serum iodine levels reached maximum values at the first day was still elevated at the 4th and 7th days, but T3, T4 and TSH values remained within the normal limits. Iodine did not produce alterations in the levels of thyroid hormones and TSH, although it is known that a considerable amount of it is absorbed from the intestinal lumen.

Administration, Topical↗