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Biomedical subjects

S Cervera

Publications and source records attributed to S Cervera.

12 recordsLinked to original sources
PubMed1998

Tianeptine therapy for depression in the elderly.

1. Depression is frequent in the elderly but difficult both to diagnose and treat due to a number of distinctive features. 2. Tianeptine is a novel antidepressant with a reverse mode of action to that of the selective serotonin reuptake inhibitors yet with proven efficacy and safety. 3. 63 elderly patients (mean age:68.8 years; range:65-80 years) with depressive symptoms (major depression:55.6%; dysthymia:44.4%) were included in a 3-month open multicenter study with tianeptine (25 mg daily). 4. 43 patients (68.2%) completed the study. There were no drop-outs due to side-effects. Total Montgomery and Asberg Depression Rating Scale scores were significantly decreased (p < 0.01) on day 14, with a response rate of 76.7%. 5. Improvements were also observed in anxiety and cognitive performance. Side-effects were seen in only 11.7% of patients, with no changes in laboratory or ancillary safety parameters. Tianeptine is thus effective and well tolerated in this category of patient.

Aged↗
PubMed1990

Moclobemide versus clomipramine in the treatment of depression: a multicentre trial in Spain.

The efficacy, tolerability and safety of moclobemide were compared with those of clomipramine in a double-blind, randomized parallel group study over 4 weeks. Patients were suffering from various forms of depression: 33 received moclobemide and 31 clomipramine. The mean score on the Hamilton Rating Scale for Depression decreased gradually in both groups, with no significant differences between them; the final scores showed an improvement of 57% in the moclobemide group and 60% in the clomipramine group, compared with baseline. The investigators' assessment of efficacy at the end of treatment was good or very good for 60% of moclobemide patients and 50% of clomipramine patients, and tolerance was good or very good for 31 patients on moclobemide and 26 on clomipramine. The drugs thus showed comparable antidepressant efficacy, and both were mostly well tolerated, although adverse events were more prevalent in patients treated with clomipramine.

Adult↗
PubMed1989

[Usefulness of neuroendocrine function tests in the differential diagnosis of depression].

In order to find the correlation between dexamethasone suppression test (DST) and TSH response to TRH in the differential diagnosis of subtypes of depression, and to evaluate the possible relationship between Hypothalamic-Pituitary-Adreno-cortisol axis, Hypothalamic-Pituitary-Thyroid axis function, psychopathological symptoms, and the possible influence of age and sex, 107 depressed patients were studied. The relationship between both tests (DST and THS response to TRH) and the subtypes of depression was unspecific. The results did not show psychopathologic differences between depression subgroups. DST appeared to be a good marker for the "state" of illness, whereas TSH was better as a predictor for the outcome.

Adolescent↗
PubMed1989

[Anorexia nervosa: study method and sleep analysis].

By studying anorexia nervosa with an Integrated Inventory and the quality and the quantity of sleep applying Hauri's scale for the analysis of dream contents, the sleeping habits of 50 anorexic patients who were under treatment have been studied. The results show that sleep in these patients is similar and sometimes better in quantity and quality than those in the control group. Their dreams are characterized by an almost total absence of sexual, aggressive and alimentary contents, and that reality, active participation, unpleasant feelings and sensory-perceptive elements are predominant.

Adolescent↗
PubMed1985

Clinical and neuroendocrine features of endogenous unipolar and bipolar depression.

A group of 19 patients suffering from endogenous unipolar depression was compared with another group of eight patients with bipolar depression. Comparisons were based on psychopathological features together with results of the dexamethasone suppression test and the thyrotropin releasing hormone stimulation test. Unipolar patients showed more frequent loss of weight, reduced appetite, autonomic disturbances, muscular tension, sadness, and reduced sexual interest, whereas bipolar patients showed more frequent hostile feelings. Each neuroendocrine test identified at least 50% of the patients in each group. The combined use of both tests identified about 75% of the patients. The bipolar depressives obtained slightly but not significantly higher rates of positive results in each test and a more frequent association of abnormality in both tests.

Adult↗
PubMedDate not supplied

[A mid-term clinical and hemodynamic evaluation of the Wessex and Hancock II bioprostheses].

The purpose of this study is to compare clinically and hemodynamically the Wessex and Hancock II porcine bioprostheses. We compared functional class and data from echo-Doppler in 34 Wessex bioprostheses (group A) with those in 42 Hancock II bioprostheses (group B). We subdivided group A into A1 and A2. A1 was made up of 23 Wessex manufactured since 1986. A2 constituted 11 Wessex made before 1986 which belonged to a series with some variations in the manufacturing process, and in which some early dysfunctions have been described. We compared data from these sub-groups between each other as well as with those of group B. The groups were homogeneous in age, sex, patients body surface and the time elapsed since the prosthetic implant. The mean mitral gradient, the mitral area, the peak aortic gradient and the regurgitation incidence were similar in groups A and B. In A2 the mean mitral gradient was significantly superior to that of group B (7.1 +/- 1.1 mmHg vs 5.4 +/- 1.4 mmHg; p less than 0.01), and the mitral area showed a tendency to be inferior, although with no statistical significance. The functional class of the patients was similar in all the groups. We conclude that the Wessex bioprosthesis presents hemodynamic data and functional class similar to those of the Hancock II, with the exception of a sub-group of Wessex manufactured before 1986 which presents mean mitral gradients superior to the others and which would warrant further studies.

Bioprosthesis↗
PubMedDate not supplied

[Treatment with tianeptine for depressive disorders in the elderly].

Depression is frequent in the elderly but difficult both to diagnose and treat due to a number of distinctive features. Tianeptine is a novel antidepressant with a reverse mode of action to that of the selective serotonin reuptake inhibitors yet with proven efficacy and safety. 63 elderly patients (mean age: 68.8 years; range: 65-80 years) with depressive symptoms (major depression: 55.6%; dysthymia: 44.4%) were included in a 3-month open multicenter study with tianeptine (25 mg daily). 43 patients (68.2%) completed the study. There were no drop-outs due to side-effects. Total Montgomery and Asberg depression rating scale scores were significantly decreased (p < 0.01) on day 14, with a response rate of 76.7%. Improvements were also observed in anxiety and cognitive performance. Side-effects were seen in only 11.7% of patients, with no changes in laboratory or ancillary safety parameters. Tianeptine is thus effective and well tolerated in this category o patient.

Aged↗