Biomedical subjects

S Chabert-Gisselbrecht

Publications and source records attributed to S Chabert-Gisselbrecht.

2 recordsLinked to original sources

PubMed1995

[Oncogenes and their discovery].

Oncogenes have been discovered through the study of oncogenic retroviruses. Viral oncogenes present in the viral genome are the genes responsible for the transforming properties of these viruses. Viral oncogenes are altered forms of cellular genes, designated as proto-oncogenes, that have been transduced into the genome of transforming retroviruses. Deregulated expression or structural alteration of cellular proto-oncogenes by amplification, mutation or translocation has been implicated in the occurrence of human cancers.

Animals↗

PubMed1982

[Induction of infectious Friend virus after treatment with 5-azacytidine of a non-virus-producing erythroleukemia line (HFL/b)].

A Friend virus induced erythroleukemia cell line (HFL/b cells) did not produce infectious MuLV and only expressed the defective SFFV component of Friend virus (SFFV (+), F-MuLV (-)). This line temporarily produced infectious F-MuLV following 5 azacytidine treatment. These results suggest that the F-MuLV expression is specifically repressed in these cells by a mechanism which does not affect the F-MuLV related SFFV genome.

Animals↗