PubMed Health⌕ Search

Biomedical subjects

S Chaichik

Publications and source records attributed to S Chaichik.

6 recordsLinked to original sources
PubMed1990

Surgical palliation combined with synchronous therapy in pancreatic carcinoma.

Palliative surgery has a role in nonresectable pancreatic carcinoma. We attempted to evaluate the efficacy of palliative surgery followed by synchronous therapy in such cases. A group of 92 patients was studied. Sixty-six patients (Group 1) with biliary obstruction underwent surgical biliary bypass. Twenty-six patients (Group 2) underwent explorative laparotomy only. Thirty patients (45.5%) in Group 1 and 10 patients (38.5%) in Group 2 received synchronous therapy consisting of 10 intravenous administrations of 5-fluorouracil (750 mg/m2) over 8 h, followed 8 h later by radiation with 400 rads repeated every 4 days. The mean survival for the entire group was 8.9 months. Those in Group 1 who received synchronous therapy had a mean survival of 13.5 months; those who did not 8.9 months (P less than 0.01). Patients in Group 2 who received synchronous therapy survived with a mean of 5.4 months, those who did not 2.7 months (P less than 0.01). Toxicity due to synchronous therapy was minimal. Of the 40 patients receiving synchronous therapy, 37 suffered from abdominal pains prior to initiation of therapy, 29 of which (78.4%) were free of pain upon completion of therapy. In nonresectable carcinoma of the pancreas, surgical palliation provides an acceptable survival. When combined with synchronous therapy, it results in prolonged survival and an ameliorated quality of life.

Adult↗
PubMed1987

Nail-bed melanoma.

In our series of 348 patients treated over a 10-year period, six (1.7%) had their primary lesions in the nail bed. Five of the subungual melanomas occurred in the toes and one in the thumb. Four of the lesions were of the acral lentiginous type. The delay in diagnosis was 7 months to 6 years. Four of the patients presented with advanced, neglected tumors. One had distant metastases at diagnosis. The treatment was mainly surgical. Digital amputation was carried out for local control. Five patients underwent lymph node dissection and in three of them regional metastases were found. Of the four patients with regional and distant metastases at the time of diagnosis, three died within 6 to 60 months and the fourth is alive with metastatic spread. Of the two patients with melanoma confined to the nail bed, one is free of disease 50 months following diagnosis and the other suffered from a local recurrence and has been free of disease for 30 months following wide excision and limb perfusion.

Aged↗
PubMed1980

Steroid receptors in human renal carcinoma.

Glucocorticoid- and androgen-binding receptors were demonstrated in cytosol of human renal cell carcinomas by the dextran-coated charcoal technique. Sedimentation studies using preparative ultracentrifugation indicated a 7 to 8 S binding component. None of the renal carcinoma cells tested contained detectable estrogen receptors and a few samples had a very low but demonstrable progestin receptor level. In the normal kidneys tested, cytoplasmic components that bound only androgen could be detected. Competition studies showed that progestin competed for the glucocorticoid receptor sites in all the renal tumors tested, whereas diethylstilbestrol and testosterone were weak or not competitive. It is suggested that the response of some patients with renal carcinoma to high doses of progesterone or androgens could be explained by the ability of these hormones to block the activity of glucocorticoid receptors, which might be involved in tumor growth.

Adenocarcinoma↗
PubMed1980

Exposure to radioiodine in the preconception and conception periods. A case report.

A case of radiation exposure shortly before conception is presented. The patient refused abortion and was delivered of a healthy infant. On reconsideration of the case, it was decided that the recommendation to terminate the pregnancy on the grounds of excessive exposure to radiation was unjustified. We feel that physicians should be aware that abortion in such cases is not always necessary.

Abortion, Therapeutic↗