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Biomedical subjects

S Chase

Publications and source records attributed to S Chase.

At least 19 recordsLinked to original sources
PubMed2006

Prediction of long-term occupational performance outcomes for adults after moderate to severe traumatic brain injury.

PURPOSE: To examine predictors of long-term occupational performance outcomes for adults after moderate to severe traumatic brain injury (TBI). METHOD: This study involved analysis of data from a retrospective cohort of adults (N = 306) with moderate to severe TBI discharged from a Pennsylvania rehabilitation treatment facility. Extensive pre-injury sociodemographic, injury-severity, post-injury personal (cognitive, physical, affective), post-injury environmental (social, institutional, physical), and post-injury occupational performance (participation in self-care, productivity, leisure activities) data were gathered from hospital records and using in-person interviews. Interviews occurred at a mean time of 14 (range, 7-24) years post-injury. Hierarchical multiple regression analysis was used to investigate determinants of long-term occupational performance outcomes. RESULTS: Pre-injury behavioural problems, male gender, post-injury cognitive and physical deficits, and lack of access to transportation were significant independent predictors of worse occupational performance outcomes. CONCLUSIONS: The study supports the use of a comprehensive model for long-term outcomes after TBI where pre-injury characteristics and post-injury cognitive and physical characteristics account for the greatest proportion of explained variance.

Adolescent↗
PubMed2004

Long-term outcomes after moderate to severe traumatic brain injury.

OBJECTIVE: This research examined the long-term outcomes of rehabilitation patients with moderate to severe traumatic brain injury (TBI). DESIGN: Retrospective cohort study. SETTING AND SUBJECTS: We examined consecutive records of persons with moderate to severe traumatic brain injury who were discharged from a large rehabilitation hospital in Pennsylvania from 1973 to 1989. We interviewed consenting participants (n = 306) up to 24 years post-injury. MAIN OUTCOME MEASURES: Self-rated health, activity limitations, employment, living arrangements, marital status, Community Integration Questionnaire, and use of rehabilitation services. RESULTS: Participants were most limited in activities such as managing money and shopping. Twenty-nine per cent of our participants were working full time. There were significant relationships between activity limitations and residual cognitive impairment at follow-up. Self-rated health was correlated with most instrumental activities of daily living. CONCLUSION: Our findings document health and function in a large post acute TBI population and implications for rehabilitation are discussed.

Activities of Daily Living↗
PubMed2004

Aging with traumatic brain injury: long-term health conditions.

Although traumatic brain injury (TBI) is a leading cause of death and disability in young adults, older adults over the age of 75 are also at high risk for TBI. As even mild injury can lead to disabling consequences, the long-term consequences of TBI need to be better understood, especially as the survival rate has increased dramatically in the last few decades. This research examined the prevalence of long-term health conditions after TBI. Using a retrospective cohort design, we examined consecutive records of adults with moderate to severe TBI discharged from a large rehabilitation hospital in Pennsylvania from 1974 to 1989. Baseline clinical information was abstracted from medical records. We interviewed consenting participants up to 24 years after injury. Our findings show a higher than expected prevalence of self-reported arthritis in the middle-aged population. There was also a high prevalence of problems with sleep and nerves many years post-injury. Some of the health conditions documented in this study could potentially be addressed early in rehabilitation; this study supports the screening of more physical health conditions in persons aging with TBI.

Adult↗
PubMed2001

Factors associated with perceived quality of life many years after traumatic brain injury.

OBJECTIVES: To explore factors associated with perceived quality of life (QOL) 8 to 24 years after traumatic brain injury (TBI). DESIGN: Retrospective cohort study. PARTICIPANTS: Two hundred seventy-five individuals who sustained moderate to severe TBI who were discharged from a rehabilitation hospital participated in this study. We interviewed consenting participants up to 24 years after injury. OUTCOME MEASURES: Self-rated Quality of Life Scale. RESULTS: Multivariate linear regression analyses revealed that perceived mental health, self-rated health, gender (women rating QOL higher), participation in work and leisure, and the availability of emotional support were significantly associated with QOL (P <.05). CONCLUSION: The importance of designing ongoing support programs to further reintegrate TBI survivors several years after injury is discussed.

Adolescent↗
PubMed2000

Clients' perspectives on problems many years after traumatic brain injury.

This study investigated the types of self-reported main problems that persons report many years following a traumatic brain injury. This preliminary study is part of a large ongoing study of disability and handicap in adults following traumatic brain injury. As part of an extensive interview, subjects were asked an open-ended question regarding their current main problems which they thought resulted from their traumatic brain injury. Responses were obtained from 166 adult subjects (119 men and 47 women) whose time postinjury ranged from 9 to 24 years. Categories for responses were subsequently developed. The most commonly reported categories of problems were those relating to movement (39%), cognition (36%), and sensory impairment (31%). Findings suggest that subjects' long-term concerns were related to specific impairments more than to psychosocial, emotional, or behavioral issues. Methodological issues concerning this research are discussed in relation to findings.

Adaptation, Psychological↗
PubMed1999

Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model.

The activities of linezolid, eperezolid, and PNU-100480 were evaluated in a murine model of tuberculosis. Approximately 10(7) viable Mycobacterium tuberculosis ATCC 35801 organisms were given intravenously to 4-week-old outbred CD-1 mice. In the first study, treatment was started 1 day postinfection and was given by gavage for 4 weeks. Viable cell counts were determined from homogenates of spleens and lungs. PNU-100480 was as active as isoniazid. Linezolid was somewhat less active than PNU-100480 and isoniazid. Eperezolid had little activity in this model. In the next two studies, treatment was started 1 week postinfection. A dose-response study was performed with PNU-100480 and linezolid (both at 25, 50, and 100 mg/kg of body weight). PNU-100480 was more active than linezolid, and its efficacy increased with an escalation of the dose. Subsequently, the activity of PNU-100480 alone and in combination with rifampin or isoniazid was evaluated and was compared to that of isoniazid-rifampin. The activity of PNU-100480 was similar to that of isoniazid and/or rifampin in the various combinations tested. Further evaluation of these oxazolidinones in the murine test system would be useful prior to the development of clinical studies with humans.

Acetamides↗
PubMed1999

Medication adherence in patients with HIV infection: a comparison of two measurement methods.

Two measurements of adherence, patient self-report and electronic measurement by the Medication Event Monitoring System (MEMS), were compared in a 3-month adherence study of 44 HIV-infected patients who had been placed on regimens that included protease inhibitors (PIs). The dose percentage and degree of clinically significant dosing time fluctuation were calculated monthly. The mean dose percentage by self-report versus MEMS was 97.5% versus 90.3% during month 1 of adherence monitoring, 96.5 versus 90.1% during month 2, and 98.4% versus 92.8% during month 3. Thirty-two percent of patients taking PIs and 21% of patients taking nucleoside analogues demonstrated clinically significant dosing time fluctuation. Our data confirm that self-reports of adherence overestimate true adherence behavior, and patients' self-reports of dosing times may not accurately reflect their deviation from those times.

Adult↗
PubMed1997

Antihypertensives.

Explore the source record for details and available documents.

Antihypertensive Agents↗
PubMed1995

A quantitative model for simultaneous brightness induction.

The brightness that results from stimulating a particular test-region of the retina may be depressed or enhanced by simultaneous stimulation of other "inducing"-regions. The test-region brightness may be affected by contiguous inducing-regions (local contrast effects), and by non-contiguous inducing regions (long-range effects sometimes called "assimilation"). We describe a computational model for early vision that can predict the results of brightness-matching procedures commonly used to measure these phenomena. According to this model, brightness depression reflects primarily lateral inhibition that underlies local contrast effects; whereas brightness enhancement results from processes similar, in spirit, to those described in Helson's adaptation-level theory.

Contrast Sensitivity↗
PubMed1995

Evaluation of a problem-based access knowledge system using triangulation methods.

A microcomputer-based system designed to provide nurses and physicians access to expert synthesized knowledge in the area of pulmonary arterial waveform troubleshooting has been developed and implemented. Evaluation using triangulation methods show that there was a substantive increase in knowledge in both nurses and physicians.¿.

Attitude of Health Personnel↗
PubMed1994

Context effects in visual pattern recognition by pigeons.

In the experiments described in this paper we examined the effects of contextual stimuli on pigeons' recognition of visual patterns. Experiment 1 showed a context-superiority effect. Specifically, two target forms that were identical except for location in the visual field were not discriminated when presented alone, but the compounds formed when each of these targets was placed between a nearby pair of flanking stimuli were readily discriminated. The size of the context-superiority effect decreased with increasing target-flanker separation. In Experiments 2 and 3 the two targets differed in form rather than spatial location and were readily discriminated in the absence of flankers. Under these circumstances, adding an identical pair of flankers to each target resulted in a context-inferiority effect; this is, the two target-plus-flankers compounds were less readily discriminated than the targets alone. The size of the context-inferiority effect decreased with increasing target-flanker separation. The observed effects of context are predictable from the Heinemann-Chase (1990) model of pattern recognition.

Animals↗