Biomedical subjects
S Chassagnon
Publications and source records attributed to S Chassagnon.
Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat.
Neuroprotective properties of estrogen are supported by extensive experimental evidence. In this study, the effects of estrogen were examined on the neurodegeneration secondary to status epilepticus induced by kainic acid in the rat. Chronic supplementation of ovariectomized rats with estradiol benzoate (20 microg/day) did not modify the expression of seizures monitored by electroencephalography, but significantly reduced cellular loss in the hippocampus. This neuroprotection was in particular observed in the dentate hilus and CA3 pyramidal layer when treatment with estradiol benzoate was started five days before status epilepticus induction. These findings suggest that estrogen can exert neuroprotective effects in a model of status epilepticus, in the absence of anti-epileptic properties.
[Spontaneous regression of an acute spinal subdural hematoma. MR imaging].
We report a case of acute spinal subdural hematoma which developed then regressed spontaneously. MR imaging contributed essential information for diagnosis and follow-up after conservative treatment. We made a short review of the literature and discuss the causes, pathogenesis, clinical presentation and usual treatment of acute spinal subdural hematoma. The differential diagnosis with the more frequent and extradural hematoma requiring immediate surgical evacuation is fundamental.
[Post-radiotherapy multifocal meningioma].
We report one case of radio-induced meningiomas revealed by an intracranial hypertension in an 46 year-old woman. A history of cephalic irradiation during infancy for a vascular nevus, not spontaneously reported by the patient, had been discovered because of the association with a radio-induced cataract. Meningiomas are a rare, severe and late complication of cephalic radiotherapy. The history of irradiation is not always spontaneously reported by the patient.