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Biomedical subjects

S Chester

Publications and source records attributed to S Chester.

6 recordsLinked to original sources
PubMed1996

Phaeochromocytoma in pregnancy.

The Royal Women's Hospital, Melbourne, is a tertiary referral hospital with over 7,000 deliveries per year. We report 3 cases of phaeochromocytoma in pregnancy at the hospital in the 20-year period since 1976. The first case was unsuspected and resulted in a maternal death. The subsequent 2 cases were diagnosed antenatally with successful outcomes for both mother and baby. The 3 cases demonstrate the importance of an early antenatal diagnosis and the special management problems of phaeochromocytoma in pregnancy. The diagnosis of phaeochromocytoma should be considered in any pregnant women with severe hypertension, particularly if presenting before 20 weeks' gestation, labile, or associated with sweating, palpitations or headaches.

Adrenal Gland Neoplasms↗
PubMed1996

Cardiopulmonary arrest in pregnancy: successful resuscitation of mother and infant following immediate caesarean section in labour ward.

Our patient experienced cardiopulmonary arrest secondary to profound hypotension and was unable to be resuscitated with external cardiac massage and assisted ventilation. This case demonstrates the need for continued vigilance by medical and nursing staff when epidural anaesthesia is being established. Resuscitation equipment should be available in the labour ward as cardiopulmonary resuscitation and immediate Caesarean section can be lifesaving in the event of a cardiopulmonary arrest.

Adult↗
PubMed1992

Intraoperative patient-controlled analgesia: an alternative to physician administration during outpatient monitored anesthesia care.

Outpatients undergoing minor diagnostic and therapeutic procedures associated with intermittent discomfort are frequently given bolus injections of intravenous opioid analgesics. In a group of 80 healthy women undergoing vaginal ovum pickup procedures, we evaluated patient-controlled administration of alfentanil using a patient-controlled analgesia device (with a lockout interval of 3 min) as an alternative to conventional physician-controlled administration. The two alfentanil administration techniques were equally effective in providing intraoperative analgesia. The average alfentanil dosage requirements were 1.49 +/- 0.50 and 1.46 +/- 0.55 micrograms.kg-1.min-1 (mean +/- SD) in the physician- and patient-controlled groups, respectively. The incidence of postoperative nausea was the same in both treatment groups (8%). Even with the mandatory lockout interval, intraoperative patient-controlled administration of alfentanil was comparable to physician-controlled administration with respect to patient comfort and satisfaction during vaginal ovum pickup procedures.

Adult↗
PubMed1988

Hexosaminidase A activity and amyotrophic lateral sclerosis.

Abnormalities of GM2 ganglioside metabolism owing to hexosaminidase A (Hex A) deficiency have been associated with ALS phenotypes. The clinical features described in these ALS patients with Hex A deficiency include early onset, positive family history, and/or long disease duration. In an attempt to determine prospectively the incidence of Hex A deficiency within an ALS population, the records of The Mount Sinai Medical Center ALS Clinic were reviewed to select those patients with "atypical" ALS (total N = 52), i.e. onset before age 35, positive family history, and/or disease duration greater than 90 months. The control group (total N = 50), "typical" ALS patients, did not fulfill any of these historical criteria. Hex A activity determined in isolated peripheral blood leukocytes was normal in all typical ALS patients (mean 67.3%). Hex A deficiency was not found in any atypical ALS patients. Thus, Hex A deficiency apparently is an unusual etiology of typical or atypical ALS but is of medical and genetic importance in individual families.

Age Factors↗