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Biomedical subjects

S Chisholm

Publications and source records attributed to S Chisholm.

9 recordsLinked to original sources
PubMed1996

Neutralizing and enhancing activities of human respiratory syncytial virus-specific antibodies.

The neutralizing and enhancing activities of respiratory syncytial virus (RSV)-specific antibodies were examined. These two biological activities were measured for a panel of six monoclonal antibodies (MAbs) specific to the RSV surface F and G glycoproteins. Four MAbs specific for the F protein possessed both neutralizing and enhancing activities. One MAb (11-2-D2), specific to the G protein, enhanced RSV infection of U937 cells, a human macrophage cell line, but did not neutralize virus infectivity. One MAb (11-3-A3), specific to the F protein, efficiently neutralized virus infectivity but did not enhance RSV infection of U937 cells. MAb 11-3-A3 neutralized representative strains of the two antigenic subtypes of RSV. Assays performed with mixtures of MAbs showed that high concentrations of MAb 11-3-A3 masked the enhancing activity of MAb 11-2-D2. The assay of mixtures of two MAbs possessing only enhancing activities demonstrated that this response was synergistic. The role of neutralizing and enhancing antibodies in determining the outcome of RSV infection was examined for infants from whom cord blood serum samples were collected at birth. There was no significant difference in the magnitude of the serum-enhancing activities between infants who were hospitalized with RSV infections and a group of age- and sex-matched control infants with no reported respiratory illness requiring hospitalization. However, the results indicated a possible correlation between RSV infection of the infants and the occurrence of in vitro antibody-dependent enhancement of the cord blood sera at a serum dilution of 10(-2). A significant inverse correlation was found between the plaque-neutralizing and enhancing activities of the cord blood sera from infants, irrespective of subsequent RSV infection. These data are discussed in relation to the possible contribution of antibody-dependent enhancement to the normal course of RSV pathology in vivo.

Antibodies, Monoclonal↗
PubMed1990

Lyme disease in the highlands.

Serological results for Borrelia burgdorferi were examined for one year. The results suggest a 'pocket' of infection in one Highland general practice. In this practice, most of the patients had exposure to tick bites and rashes were frequent. There were difficulties in relating serological results to clinical features and management of some patients.

Adolescent↗
PubMed1977

Predicting adjustment of heart patients with the Cardiac Adjustment Scale.

Cardiac Adjustment Scale (CAS) scores for 74 cardiac patients between 31 and 64 years of age who completed a comprehensive cardiac rehabilitation program were examined to determine whether they could predict return to work, judged adjustment to cardiac disability, and participation in the rehabilitation program. CAS scores proved to be unrelated to either vocational status or program involvement. Low CAS scores were associated with maladjustment, but higher scores were associated equally with good and poor adjustment. The results suggested that the CAS alone was of little value in increasing the accuracy of prediction of psychological or vocational adjustment with the population studied.

Adaptation, Psychological↗