[Multiple foreign body aspiration].
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Aged↗
Biomedical subjects
S Christoph
Publications and source records attributed to S Christoph.
[Abducens paralysis from the viewpoint of the ENT physician and skull base surgeon].
BACKGROUND: Among the nerves supplying the extraocular muscles, abducent nerve paralysis is the most common one resulting in double vision. Surveys confirm that the palsy is most often benign and transient. In most cases Ophthalmologist, Neurologist, Pediatrician and Physician are involved in diagnosis and treatment of this symptom. The Otorhinolaryngologist is needed in the least common cases of abducent nerve palsy due to intra- or extracranial diseases, for example trauma, inflammatory complications or tumors of the skull base. PATIENTS AND RESULTS: 12 patients (6 male, 6 female) with abducent nerve paralysis were seen and treated in the Department of Ear-Nose- and Throat Diseases, Head, Neck and Facial Plastic Surgery, Klinikum Fulda between 1984 and October 1999 and included in our series. Their records were evaluated and the main aetiology listed, was checked. An inflammatory process was the most common cause in 6 patients, one of them presented with otogenic meningitis and bilateral abducent nerve paralysis. In 4 patients neoplasm was the underlying pathology, in 1 patient head injury associated with temporal bone fracture and in 1 patient an orbital pseudotumor. Complete recovery of abducent nerve was achieved in 7 patients (58%). CONCLUSION: Using modern imaging techniques enables us to diagnose the aetiopathology of abducent nerve paralysis. Using modern imaging techniques, planning of therapeutic strategy and clarifying the prognosis of this symptom has improved considerably.
Abducens Nerve Diseases↗
Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems.
Sulfation is a common final step in the biotransformation of xenobiotics and is traditionally associated with inactivation. However, the sulfate group is electron-withdrawing and may be cleaved off heterolytically in some molecules leading to electrophilic cations which may form adducts with DNA and other important cellular structures. Since endogenous sulfotransferases do not appear to be expressed in indicator cells of standard mutagenicity tests, rat and human sulfotransferases have been stably expressed in his- Salmonella typhimurium strain TA1538 and Chinese hamster V79 cells. Using these recombinant indicator cells, sulfotransferase-dependent genotoxic activities were detected with N-hydroxy-2-acetylaminofluorene, 2-acetylaminofluorene (in the presence of co-expressed rat cytochrome P450 1A2), hycanthone, 1'-hydroxysafrole, alpha-hydroxytamoxifen and various benzylic alcohols derived from polycyclic aromatic hydrocarbons. In several cases, it was critical that the reactive sulfuric acid conjugates were formed directly within the indicator cells, owing to the inefficient penetration of cell membranes. In other cases, spontaneous benzylic substitution reactions with medium components, such as halogenide ions or amino acids, led to secondary, membrane-penetrating reactive species. Different sulfotransferases, including related forms from rat and human, substantially differed in their substrate specificity towards the investigated promutagens. It is known that some sulfotransferases are expressed with high tissue and cell type specificities. This site-dependent expression together with the limitations in the distribution of reactive sulfuric acid conjugates may explain organotropic effects of compounds activated by this metabolic pathway.
Animals↗
[Detection of hL6-mRNA: new possibilities in serologic tumor diagnosis of colorectal carcinomas].
A study was performed to detect circulating tumor cells in patients with colorectal cancer using mRNA coding for the tumor associated antigen L6. The mRNA was determined by Reverse Transcriptase Polymerase Chain Reaction and gel-electrophoresis. The L6 results were compared with the CEA levels. Peripheral blood samples were taken from 109 patients with histologically verified colorectal cancer. Statistics were carried out using CHI Square and Sokal and Rohlf's-test. Preoperatively 81.65% showed positive L6 mRNA, whereas only 58.7% had elevated CEA titers (p < 0.05). In all patients of the control group (n = 52) no L6 was detectable. Concerning our results L6 seems to be a sensitive and precise tool for diagnosing circulating tumor cells in colorectal cancer.
Antigens, Surface↗
[The SMAS (subcutaneous musculo-aponeurosis system) flap: a possibility for filling out soft tissue defects after parotidectomy].
BACKGROUND: Parotidectomies sometimes leave a conspicuous soft-tissue defect in the dorsal part of the cheek. METHODS: The authors present a modification of the standard technique of parotidectomy which is reserved for the surgical management of benign parotid tumors. The incision of the skin follows the guidelines for standard subcutaneous rhytidectomy with a modification according to the Redon incision. They use flaps of the subcutaneous musculoaponeurotic system (SMAS), which they fold or rotate in order to fill the soft-tissue defect following parotidectomy. The preparation of the skin and the SMAS in layers from the lateral to the medial aspect of the cheek does not affect the blood supply which comes from medially running vessels. RESULTS: Forty patients have been operated on using these modifications of the standard technique. A postoperative follow-up of more than one year could be controlled in 31 cases. Thirty patients showed an inconspicuous dorsal region of the cheek without a soft-tissue defect compared to the other side. They did not wish a secondary operation for an aesthetic improvement except two scar revisions. CONCLUSION: To date this surgical concept has proved its worth.
Esthetics↗
Sedimentation of biliary sludge: effect on composition of gallbladder bile from patients with cholesterol, mixed, or pigment stones.
BACKGROUND: Ultracentrifugation of bile has been used extensively to remove insoluble material such as sludge from bile before further studies of cholesterol nucleation. Although it has been recognized that this procedure may affect the composition of gallbladder bile, it has not been studied systematically in different gallstone populations. Therefore, we investigated the concentration of biliary lipids, protein, mucin, and bilirubin before and after ultracentrifugation. METHODS: Gallbladder bile samples were aspirated during laparoscopic surgery from 66 patients (35 with cholesterol, 16 with mixed, and 15 with pigment stones). RESULTS: Whereas the concentrations of bile acids, phospholipids, protein, and bilirubin in gallbladder bile did not change significantly after ultracentrifugation, cholesterol (20.6 +/- 1.6 to 14.8 +/- 1.2 mmol/l) and mucin concentrations (0.99 +/- 0.2 to 0.67 +/- 0.1 mg/ml) and the cholesterol saturation index (1.68 +/- 0.12 to 1.31 +/- 0.10) decreased significantly in gallbladder bile from patients with cholesterol stones. CONCLUSIONS: Sedimentation of biliary sludge may profoundly affect the composition of gallbladder bile, which has to be considered in studies of cholesterol saturation and nucleation. The cholesterol concentration difference between native and ultracentrifuged bile reflects the insoluble crystalline fraction of cholesterol and may be useful for quantitation of the mass of cholesterol crystals in gallstone-associated bile samples.
Bile↗
[How I do it. How does one intraoperatively preserve and condition a free microsurgical flap?].
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Glucose↗
[ESWL with the Lithostar--experience with 3,000 treatments].
The experiences with 3,000 extracorporeal shock wave lithotripsies of kidney and ureteral calculi using the Lithostar are reported. Indications, contraindications and therapeutic approach are reviewed and the importance of out-patient follow-up is stressed. The success rate of 75% (including further spontaneous passage of residual desintegrated calculi) is good in the view of an unselected and unfavourable patient population. In the other patients a second ESWL treatment may be necessary. In the initial period in 6% of the patients percutaneous nephrolitholapaxy or open operation have been performed whereas in the last 100 patients it was not necessary.
Adolescent↗