PubMed Health⌕ Search

Biomedical subjects

S Constantiniu

Publications and source records attributed to S Constantiniu.

35 records · Page 2Linked to original sources
PubMedDate not supplied

[Epidemiological study of salmonelloses in the Moldavia area].

A study was carried out on the epizooto-epidemiologic potential of certain domestic and wild animal species (cold-blooded), of the environment (residual waters) and food products, and their role in maintaining Salmonella endemics (others than the typhoid-parathyphoid group). Account was kept of the incidence of Salmonella and its circulation in subjects exposed to occupational risks and in the mass of the population, including those with clinically manifest salmonellosis and the clinically healthy carriers. The results showed the importance of domestic animals in maintaining the endemic (fowl 15%, swine 10%, bovine 5%). The isolated serotypes were identical to those found in residual eaters, in patients and in carriers. The sensitivity test to antibiotics revealed resistance to more than two antibiotics in 65%, except for the strains isolated from reptiles. Reorganization measures appear necessary in order to restrict the circulation of Salmonella in farm animals and to reduce the risks of infection in humans.

Animals↗
PubMedDate not supplied

Detection of beta-lactamase production and enzyme profiles in Enterobacteriaceae isolated in Moldova.

In our study, out of 449 Enterobacteriaceae strains isolated between 1985 and 1990, 16 strains (3 Proteus, 6 nontyphoidal Salmonella, 7 Escherichia coli) were resistant both to Ampicillin- Sulbactam and Amoxycillin-Clavulanic acid associations. The activity profiles of the beta-lactamases produced by these resistant strains are described. Sarcina lutea ATCC 9341 was used as test strain. The effect of the enzymatic filtrate against beta-lactam antibiotics: Ampicillin, Cloxacillin, Cefadroxil, Cefuroxime, Cefotaxime, Ceftriaxone, was followed up. The enzyme types were established according to the ability of inactivating the tested antibiotics. Penicillins and cephalosporins were inactivated by these enzymes, except for Carbenicillin and Oxacillin. These beta-lactamases were resistant to Sulbactam and Clavulanic acid. In the studied Salmonella strains they are plasmidic codified, demonstrating that they belong to a new beta-lactamase class.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Enterobacteriaceae isolated in eastern Romania: the evolution of ampicillin sensitivity in the 1970-1995 period].

The activity of ampicillin against 3383 Enterobacteriaceae (community and clinical isolates), collected in Eastern Romania, during 25 years was tested. Data were prelucrated by the box-plot method proposed by Simpson and Donnelly. The resistance degree for all species tested has progressively increased. In the studied region Enterobacteriaceae strains maintain their natural sensitivity only exceptionally: e.g., S. typhi and S. java, with limited circulation. Enterobacteriaceae which have contact with the resistance genic reservoir of the colon microbiota during the justified or nonjustified antibiotic treatment development resistance to usual antibiotics in the same ratio as most existent commensals present in this habitat.

Ampicillin↗
PubMedDate not supplied

Development of resistance in Shigella flexneri isolates obtained in the past 20 years in eastern Romania.

Our study is focused on the antimicrobial activity for a number of 626 Shigella flexneri strains collected from epidemic outbreaks and hospitalised patients during 1976-1995 period, in Eastern Romania. The metodology used for determining the in vitro activity of the antimicrobials was that described by NCCLS. The agents which are currently used in therapy (ampicillin, tetracycline, chloramphenicol) are less active than the newer drugs (third generation cephalosporins, aztreonam, imipenem, ciprofloxacin) for which sensitivity ranged between 93-100% The associated resistance between ampicillin, tetracycline, chloramphenicol was demonstrated. Isolates with MIC values for ampicillin > 8 micrograms/ml are still sensitive to the modern beta-lactams. For ampicillin/sulbactam association, sensitivity decreases from 100% in 1990-1993 to 43% in 1994-1995.

Cross Infection↗