[Iatrogenic lung injury in treatment with antibiotics and chemotherapeutic drugs. A further clinico-statistical contribution].
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Biomedical subjects
Publications and source records attributed to S Conte.
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Despite growing interest in the Landau-Kleffner syndrome there have been few reports dealing with language disorders in recent years. The authors present a clinical case of a child with Landau-Kleffner syndrome focusing particularly on the relationship between language disorders and electroencephalographic abnormalities. The authors emphasize that the language disorders primarily affect the receptive sphere and that there seems to be a relationship between abnormalities during sleep with a deterioration in verbal comprehension.
We have examined the injury experience in Major League Baseball as reflected by the disabled list, based on data presented by American Specialty Companies in their publications, to examine any changes in injury rates over the past 11 years. It is reasonable to expect that improvements in training and conditioning, diagnostic methods, and surgical treatment over the last 11 years would have reduced injuries and resulted in fewer players on the disabled list. Yet, such does not appear to be the case. There is no evidence that the number of injuries in Major League Baseball has declined over the last decade; on the contrary, it appears that both the number of players and player days on the disabled list have increased. Team membership, injury location, and position do not appear to be related to the increase. Nor does it appear that the increase in injuries is a result of more sensitive diagnostic tests allowing the diagnoses of previously unrecognized injuries. Whatever the reason, it is significant that publicly available data, when viewed over an 11-year period, reveal a gradual and consistent increase in reported injuries--suggesting a problem that deserves attention.
Pattern-reversal visual evoked potentials (EPs) were recorded in seven adult subjects to assess the existence of rhythmic variations in processing visual information at a primary stage. During a session of two hours, sixty EPs were recorded on the left and right cerebral hemispheres. The amplitude of N75-P100 component was measured. Remarkable variations were found with a periodicity from 15 to 60 min in six out of seven subjects. No hemispheric differences were found in the rhythmic variations. The results are in agreement with the behavioral data which show ultradian variations in visual performance depending on a general activation oscillator.
Developmental reading disability (dyslexia) has traditionally been attributed to impaired linguistic skills. Recent psychophysical data suggest that dyslexia may be related to a visual perceptual deficit. A few visual evoked potential (VEP) studies have addressed this hypothesis, but their results are far from consistent. We submitted 9 dyslexic subjects and 9 age- and sex-matched normal controls to checkerboard pattern reversal VEPs. The main experimental variables were: large (0.5 cycles per degree; cpd) and small (2 cpd) checks and two reversal frequencies (2.1 Hz and 8 Hz); mean luminance and contrast (60 cd/m2 and 50%, respectively) were kept constant in all four conditions. Transient VEP (2.1 Hz) parameters did not differ between controls and dyslexics at 2 cpd. At 0.5 cpd, N70 amplitude was significantly smaller and N70 latency significantly shorter in dyslexics. Amplitudes for the fundamental frequency (8 Hz), as well as for the second and third harmonics of the steady-state VEPs were smaller in dyslexics for both stimulus sizes. A discriminant analysis correctly classified each subject. Our data confirm the hypothesis of a perceptual deficit in dyslexic subjects. The abnormalities are related to spatial and temporal stimulus frequencies: they appear when large stimuli are presented, or when the stimulation frequency is high. These data support the hypothesis of selective magnocellular dysfunction in dyslexia.
Axillary seroma is absolutely the most frequent complication of breast cancer surgery. The Authors have accrued 100 consecutive breast cancer patients in a randomized study in order to compare seroma incidence by removing drains on 2nd postoperative day (1st arm) versus 3rd postoperative day (2nd arm); 48 patients were accrued in the first arm and 52 in the second. All patients received a standard axillary dissection. Two suction drains were placed. A compressive medication was applied after surgery. Patients started physiotherapy on the 1st postoperative day. The overall seroma prevalence was 21%. We have 8/48 (16%) seromas in the 1st group and 13/52 (25%) in the 2nd. No significant differences were registered between two arms. Clinical seroma was treated by needle aspiration and medication with a steroid. Conclusions coming out from this study are: 1) early drains removal doesn't increase seroma rate; 2) axillary clearance has to be performed removing en bloc the fatty tissue respecting surgical plains; 3) apply a compressive bandaging; 4) early arm physiotherapy; 5) medication with steroid may reduce the fluid formation.
The prevalence of hepatitis C (HCV) was studied in the operative practice of one surgeon for a period of 18 months (1/1/98-31/6/99). Patients were also tested for measurement of liver enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and hepatitis B virus surface antigen (HbsAg). Out of a total of 911 consecutive patients, 37 (4.06%) were found to have anti-HCV antibodies, using a second-generation screening assay, and 10 (1.09%) to have anti-HBV antibodies. None of the patients (0%) had both anti-HBV antibodies and anti-HCV antibodies. Ten and 21 patients positive for HCV (27% and 56%) were found to have high AST and ALT levels, respectively; 1 and 1 patients positive for HBV (10% and 10%) were found to have high AST and ALT levels, respectively. The authors demonstrated the prevalence of HCV and HBV infection or previous exposure to be higher in the trauma patients (6.6%) who required orthopaedic surgery than in the elective orthopaedic patients (3.3%), and the need for full screening without risk factors. All values for p were calculated using Yates's corrected X2 or Student's t test.
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The peritoneal papillary serous carcinoma (PPSC) is a rare tumor more frequently revealed in female. The onset mean age is 56 years. It implicate peritoneum, ovary's surface and pelvis. The histology of this disease is similar to papillary serous carcinoma ovary (PSCO). The PPSC histogenesis is probably correlated to coelomatic embryonal epithelium. Clinical characteristics are abdominal swelling, constipation, nausea, emesis, inappetence, feel unwell, lose weight. The cytoreductive surgery and the cisplatinum chemotherapy, and other treatments like immunotherapy and radiotherapy, increase the PSCP patient survival. A case of a 51 years old patient with previous surgery for breast cancer is here described. She show some of the yet described clinical findings. At the surgery we found the typically serous peritoneal localizations. We performed a debulking, and the patient died 14 months after the operation due to the disease progression.
The Authors report their experience in surgical management of sacrococcygeal fistulas treated by radical excision and subcutaneous/cutaneous rhomboid flap. This is a simple, safe surgical technique and the patients can be treated in day surgery by spinal anesthesia.
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We describe two cases of oculo-auricolo-vertebral dysplasia (OAV). The OAV spectrum is markedly broad and in some instances could results in diagnostic problems. One of our cases is classic Goldenhar syndrome. The other is a subgroup with microtia and mandibular hypoplasia. In the OAV the possibility of hearing impairment requires early recognition.