PubMed Health⌕ Search

Biomedical subjects

S Conti

Publications and source records attributed to S Conti.

At least 145 records · Page 8Linked to original sources
PubMed1982

Venous thromboembolism prophylaxis: a survey of its use in the United States.

Despite controversy about their effectiveness, low-dose heparin therapy and elastic stockings were the methods most frequently selected by surgeons in a national survey on thromboembolism prophylaxis. These methods were selected even for patients with an extremely high risk of thrombosis. Surgeons responding to this survey apparently did not discriminate between degrees of patient risk, did not recognize the limitations of low-dose heparin and elastic stockings in protecting high-risk patients, and were unfamiliar with more effective methods of prophylaxis, ie, warfarin, dextran, and intermittent pneumatic compression. There is clearly a need for more specific data regarding the safe use of effective thromboembolism prophylaxis in surgical patients.

Anticoagulants↗
PubMed1982

A comparison of high-dose versus conventional-dose heparin therapy for deep vein thrombosis.

Although heparin has been used for the treatment of deep vein thrombosis (DVT) for more than 40 years, controversy still exists regarding optimal doses and the need for monitoring. In this retrospective survey (January 1979 to December 1981) we compared two approaches to heparin therapy--high-dose heparin without monitoring versus conventional-dose heparin with monitoring. All patients had objectively documented DVT and each group was comparable with respect to age, gender, risk, factors, and extent of thrombosis. The high-dose group (n = 26) received a heparin bolus of 150 mu/kg followed by continuous intravenous infusion of 30 to 40 mu/kg/hr. The conventional-dose group (n = 95) received a bolus of 25 to 50 mu/kg with subsequent continuous intravenous doses adjusted to maintain the activated clotting time within a therapeutic range (150 to 190 seconds). There were no thromboembolic complications in the high-dose group, symptom resolution was prompt, and significant bleeding occurred in 8%. In the conventional-dose group, thromboembolic complications occurred in 10%, bleeding occurred in 12%, and only one third experienced prompt resolution of symptoms.

Adolescent↗
PubMed1980

Heparin therapy for deep venous thrombosis.

One hundred fifty-six cases of deep venous thrombosis were reviewed. A previous episode of thrombosis, seen in 47 percent of the patients, was the most common predisposing factor. Medical illness, operation and local trauma were other important predisposing factors. Treatment consisted of continuous intravenous heparin therapy monitored by the activated coagulation time of whole blood (ACT). Thirty-three patients with an average ACT greater than 180 seconds had a more rapid recovery and had no recurrent deep venous thrombosis, embolism or failure to improve. Recurrent thrombosis, embolism or failure to improve was seen in 7 of 65 patients with an average ACT below 180 seconds. Major bleeding, defined as life-threatening bleeding or bleeding requiring transfusion, was not increased when the ACT was over 180 seconds, although minor bleeding was increased. Bleeding was also increased in women, elderly and postoperative patients. We advocate the use of higher doses of heparin to treat most patients with deep venous thrombosis because of the more rapid and complete recovery.

Adolescent↗
PubMed1980

Splenic artery ligation for trauma. An alternative to splenectomy.

Splenic artery ligation without splenectomy was successfully used to control hemorrhage after blunt injury to the spleen. A review of experimental and clinical reports on splenic artery ligation reveals that this technique is well tolerated because of fairly extensive collateral blood supply to the spleen. The blood supply to the spleen is described in detail.

Adolescent↗
PubMed1980

Coronary risk factors predicting coronary and other causes of death in fifteen years.

A multivariate analysis employing the multiple logistic function model has been performed for the prediction of coronary heart disease (CHD) deaths and of other causes of death as function of 14 coronary risk factors measured at entry examination in the pool of two Italian rural population samples, made of 1712 men aged 40-59 at entry and followed for 15 years. A limited number of factors--namely age, serum cholesterol, blood pressure, smoking habits, forced expiratory volume, diabetes--yielded significant coefficients variously associated each other in the different solutions. They were able to provide a satisfactory discrimination between cases and non cases, not only for CHD but also for other end-points including strokes, cancer and lung cancer in particular, chronic bronchitis, and all causes of death. A suggestive prediction of violent causes of death was possible thank to a significant coefficient attributable to blood pressure. Serum cholesterol was significantly contributory only in the prediction of CHD. The multipotentiality of some factors is stressed in view of the planning of community prevention programs directed towards several chronic conditions at the same time.

Adult↗
PubMed1980

[Automated direct antimicrobial susceptibility testing of urine specimens].

Two microscopical screening methods have been used to assay the suitability of urine samples for automated direct antimicrobial susceptibility testing by the means of a "MS-2 Microbiology System" apparatus. Gram stained smears showed if specimens were monomicrobic and fresh-mount bacterioscopy gave information about presumptive counts to establish inoculum size. The results obtained by the automated method have been compared with those of the direct disk diffusion method and the classical Stokes method on a single isolated colony. The three systems were reliable and only 7% of specimens gave major discrepancies and 15% minor errors. The influence of each antibiotic drug and of each bacterial species on the discrepancies has been discussed. Direct susceptibility testing by MS-2 seems to be accurate and in the same time so fast (5-6 h vs. 18-24 h) to appear very useful in the rational guide of chemotherapy in the more severe UTI.

Anti-Bacterial Agents↗
PubMed1980

[Incidence and prediction of coronary heart disease in the Italian cohorts of the Seven Countries Study. 10 year experience (author's transl)].

Three cohorts of man aged 40-59 at entry have been enrolled in Italy within the Seven Countries Study and followed-up for 10 years. They included demographic samples in the rural areas of Crevalcore, north Italy (n. 993) and of Montegiorgio, central Italy (n. 719) and a sample of Railroad men living in Rome and surroundings (n. 768) with an entry participating of about 92% and a 5 and 10 year follow-up participating of about the same level. Incidence of coronary heart disease in 10 years in men coronary-free at entry has been, for the pool of the three cohorts, of about 0.4% per year for hard criteria coronary heart disease (coronary deaths and hard infarcts) and of about 1% per year for all kinds of coronary heart disease including softer diagnoses. Differences between cohorts were small and altogether not significant except for coronary deaths which were higher in the Railroad group than in Montegiorgio. The prediction of coronary heart disease as function of the entry levels of some risk factors, estimated by the multiple logistic equation, suggested that also for these Italian samples, age, blood pressure, serum cholesterol, smoking habits and physical activity (the latter with a protective role) are the main risk factors although cholesterol seems to play a lesser role in the Railroad group than in the Rural cohorts. Proportions of 34 to 68% of the observed cases were located in the upper 20% of the distribution of the estimated risk and the ratio between cases in the upper and bottom quintile of risk ranged 4 to 14 folds. The degree of discrimination suggested by these and other indicators resulted to be directly related to the severity of the coronary heart disease manifestations considered as end-points (deaths, hard cases, all cases). Such varying discriminating role was mainly due to the varying predicting power of serum cholesterol.

Adult↗
PubMed1979

Hepatic artery ligation.

The use of hepatic artery ligation (HAL) in various clinical situations is illustrated by presenting a series of eight patients. The indications for HAL included ruptured hepatic tumors, spontaneous liver rupture, delayed hemorrhage after liver trauma, hematobilia, hepatic artery aneurysm, and hemorrhage after liver biopsy. Conventional methods of hemostasis had been used in some of these patients, but failed to control hemorrhage. The reasons for the relatively late adoption of hepatic artery ligation in treating liver hemorrhage are discussed and placed in proper prospective. Hepatic artery ligation has been shown to be such an effective method of controlling hemorrhage from the liver that other methods, such as packing and mass suture, which are unsafe and ineffective, should be abandoned. Major resection should be done only when an entire lobe of the liver is reduced to pulp or when exposure and repair of the retrohepatic vena cava are necessary.

Adult↗
PubMed1978

Fatal peritonitis after massive blood transfusion: case report.

A case is presented in which successful repair of a superior vena cava gunshot wound was followed by death due to peritonitis. A mild case of endometritis progressed to generalized peritonitis after the patient's immune defenses were compromised by massive transfusion of banked blood. Clinicopathologic correlation is provided.

Abortion, Induced↗