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Biomedical subjects

S Corbett

Publications and source records attributed to S Corbett.

23 records · Page 2Linked to original sources
PubMedDate not supplied

Combined ionizing radiation and thermal injury in the rat. Evaluation of early excision and closure of the burn wound.

The present study was undertaken to establish an animal model of combined whole-body irradiation and thermal injury and to determine the effectiveness of early excision and closure of the burn wound in such a model. Whole-body irradiation over a range of doses resulted in a predictable mortality rate, with an LD50/30 of 783 rad with 95% confidence limits of 737 and 823 rad. A controlled 10% body surface area full-thickness thermal injury resulted in no deaths in 30 animals. When combined with a standard nonlethal 10% thermal injury, varying doses of whole-body irradiation resulted in widely differing LD50/30 values in three separate cohorts of rats. Excision and closure of a 10% burn 24 hours after exposure to 200 rads did not improve survival. (J BURN CARE REHABIL 1990;11:42-5)

Animals↗
PubMedDate not supplied

Intravenous modalities in the treatment of bloodborne pathogen illnesses: antibiotics, antifungals, and antivirals.

A variety of intravenous antimicrobial agents are used to treat infections with bloodborne pathogens. In using these agents to manage our patients, as well as any accidental employee exposure, it is important to understand how these agents work, and in which settings they are appropriate. This article will briefly review the historic development of antimicrobial agents and examine the agents according to the five basic mechanisms of action. Resistance to antimicrobial agents also will be discussed, as will the clinical and other factors that can positively or negatively affect the outcome of therapy.

Anti-Bacterial Agents↗